Sodium alginate (≈39% in guluronic acid blocks, Mw ≈ 100 kDa), Span 80 (sorbitan monooleate), Tween 80 (polysorbate), isopropyl myristate (≥98%), calcium chloride (CaCl2), sodium chloride (NaCl), Nile red, vitamin E (α‐tocopherol, ≥ 99.5%), corn oil, poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g mol−1), silicone oil, and photoinitiator 2‐hydroxy‐2‐methyl‐1‐phenyl‐propan‐1‐one (Darocur 1173) were purchased from Sigma–Aldrich. Ibuprofen (99%, ACROS Organics) was purchased from Fisher Scientific to be used as an API. Sucrose (ultrapure) was purchased from VWR Life Science.
Darocur 1173
Manufactured by Merck Group
Sourced in United States
Darocur 1173 is a photoinitiator used in the curing of UV-curable coatings, inks, and adhesives. It is a liquid compound that generates free radicals upon exposure to UV light, initiating the polymerization process.
Automatically generated - may contain errors
Lab products found in correlation
Pegda, by Merck Group (6 mentions)
Peg 700, by Merck Group (2 mentions)
Tween 20, by Merck Group (2 mentions)
Fluorolink md 700, by Solvay (2 mentions)
Sylgard 184, by Dow (2 mentions)
Pkh26, by Merck Group (2 mentions)
Tween 80, by Merck Group (1 mentions)
Isopropyl myristate, by Merck Group (1 mentions)
Span 80, by Merck Group (1 mentions)
Ibuprofen, by Thermo Fisher Scientific (1 mentions)
Pegda 700, by Merck Group (1 mentions)
Rhodamine b, by Merck Group (1 mentions)
Peg 258, by Merck Group (1 mentions)
Ludox cl x colloidal silica, by Merck Group (1 mentions)
Ethanol, by Merck Group (1 mentions)
Etpta, by Merck Group (1 mentions)
Ar 310, by Thinky (1 mentions)
Poly ethylene glycol diacrylate pegda, by Merck Group (1 mentions)
Eosin y, by Merck Group (1 mentions)
Phenylbis 2 4 6 trimethylbenzoyl phosphine oxide, by Merck Group (1 mentions)
21 protocols using darocur 1173
1
Ibuprofen-Loaded Alginate Microbeads for Controlled Drug Release
2
Photopolymerized PEG-DA Particles
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Poly(ethylene glycol) (700) diacrylate (PEG-DA 700, Sigma-Aldrich) and 2- hydroxy-2-methylpropiophenone (Darocur 1173, Sigma-Aldrich) initiator are used for polymeric particles synthesis. 5% Darocur 1173 in PEG-DA 700 were used as the prepolymer solutions for all the particles synthesis.
3
Synthesis of tPIN Particles with DNA
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The pre-polymer solution for tPIN particle preparation included a mixture of the following: 20% v/v Poly(ethylene glycol) diacrylate (PEG-DA, Sigma-Aldrich, Mn = 700), 40% v/v Poly(ethylene glycol) (PEG, Sigma-Aldrich, Mn = 600), 35% v/v nanoparticles with 2% low melting agarose and 200uM free DNA as a reverse primer and 5% v/v Darocur 1173 (Sigma-Aldrich). The free reverse primer was captured in 2% low melting agarose. The free reverse primer dose not react in RT process because the nanocapsules inhibit RT non-specific binding product28 (link). The solution for the tPIN was finalized by mixing the pre-polymer solution and 1 mM acrydited DNA as a forward primer with a volume ratio of 9:1. The tPINs were produced by dropping the pre-polymer solution on the PDMS, which was pre-patterned with eight different dot codes using a jetting system (Arrayer 2000, Advanced Technology Inc., Korea)20 (link). (Figure S1 ) The solution then underwent 10 sec of UV exposure at 4.5 mJ/cm2. The preparation of the tPINs was completed through a rinsing process using 1 × PBS buffer of 0.05% Tween-20 to remove the porogens and the unbound primers. The completed particles were stored at room temperature soaked in a 1 × PBS buffer with 0.05% Tween-20.
4
Photosensitive PEG Hydrogels for Microrobotics
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The photosensitive polymer mixture used in this project consists of photo-cross-linkable polyethylene glycols (PEGs) and a photo-initiator. The ratios of each component in the mixture were: 50% (v/v) PEG diacrylate with a molecular weight of 700 (PEG 700, Sigma-Aldrich), 30% (v/v) PEG diacrylate with a molecular weight of 258 (PEG 258, Sigma-Aldrich), 15% (v/v) TE buffer (100 TE, Sigma-Aldrich), and 5% (v/v) photo-initiator 2-hydroxy-2-methyl-1-phenyl-propan-1-one (Darocur 1173, Sigma-Aldrich) as photo-initiator. In addition, a droplet (~50 μl) each of fluorescent Rhodamine B (Sigma-Aldrich) and food dye were added to facilitate the focusing of the photomask and to achieve better contrast for the microrobots suspended in DI water.
5
Fabrication of Colloidal Silica Tetrahedrons
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A precursor suspension is prepared by mixing 22 wt.% poly(ethylene glycol) diacrylate (PEG-DA, Mn = 700 g/mol, Sigma-Aldrich), 74 wt.% LUDOX CL-X colloidal silica (45 wt.% suspension in H2O, Sigma-Aldrich) and 4 wt.% 2-Hydroxy-2-methyl-propiophenone (PI, Darocur 1173, Sigma-Aldrich). After synthesis, the tetrahedrons are collected and washed with 0.5 v/v % Tween-20 (Sigma-Aldrich) solution in water.
6
Fabrication of PFPE Microfluidic Molds
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The UV-curable resin was prepared by mixing the PFPE resin (Fluorolink MD700, Solvay Solexis, Milan, Italy) with 3% w/w photoinitiator (Darocur 1173, Sigma-Aldrich, St. Louis, MO, USA). The UV-curable resin was dropped on the patterned silicon substrate (i.e., Si master) and covered with polyethylene terephthalate (PET) film as a backplane. To spread the UV-curable resin between the PET film and Si master, the PET film was rolled over the resin and cross-linked by UV irradiation at 365 nm for 5 min. After curing, the PFPE mold was detached from the Si master.
7
Synthesis of Ionic Liquid Polymer Electrolytes
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Trimethyl iso-butyl phosphonium bis(fluorosulfonyl)imide (P111i4FSI, Boron Molecular, Victoria, Australia) and sodium bis(fluorosulfonyl)imide (NaFSI, Solvionic, Toulouse, France) were dried under vacuum at 50 °C and transferred inside an Ar-filled glove box before use. Poly(ethylene glycol) diacrylate Mn 575 (PEGDA; Sigma-Aldrich, Madrid, Spain) was passed through a basic alumina column to remove the hydroquinone monomethyl ether inhibitor (MEHQ), filtered with a 0.45 μm syringe filter, and kept refrigerated at 5 °C before use. 2-hydroxy-2-methylpropiophenone (DAROCUR 1173, Sigma-Aldrich) was used as received.
8
Fabrication of Silica-ETPTA Composites
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Monodisperse silica particles with average diameters of 190, 197, 204, 224 nm, 228 nm, and 240 nm (Sukgyung AT) were washed with ethanol several times and then dried to measure the weight. The silica powders were redispersed in ethanol (99.5%, Merck) using sonication overnight, and the ethanolic dispersions were combined with ethoxylated trimethylolpropane triacrylate (ETPTA, Mn ~428 g mol−1, Sigma‒Aldrich) containing 1 w/w% photoinitiator (Darocur 1173, Sigma‒Aldrich). The amounts of ETPTA were adjusted to achieve volume fractions of silica particles at 0.3, 0.4, and 0.5 in the ethanol-free base, and the densities of silica particles and ETPTA were 2.0 and 1.11 g/cm3, respectively. The mixture was sonicated for 10 min and then kept in a convection oven at 70 °C overnight to completely evaporate the ethanol. The resulting dispersions were defoamed and mixed using a planetary centrifugal mixer (AR-310, Thinky).
9
Microfluidic Fabrication of Polymeric Microparticles
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Polymeric microparticles are produced and observed with an experimental setup, similar to the one used by Uspal, Eral, and Doyle (22 (link)). Polydimethylsiloxane (PDMS) (Sylgard 184; Dow Corning) microfluidic devices of width are fabricated according to Dendukuri et al. (65 ). Disk dimers are tracked in channels with height . Trimers and triangle and square dimers are tracked in 33-μm high channels. A UV-cross-linking oligomer, poly-(ethyleneglycol) diacrylate (PEG-DA) ( , mPa s; Sigma-Aldrich), is mixed with a photoinitiator, hydroxy-2-methylpropiophenone (Darocur 1173; Sigma-Aldrich), in a 19:1 volume ratio and the mixture is pumped through the microfluidic channel. The device, loaded with prepolymer, is mounted on the stage of a motorized Nikon Ti Eclipse inverted optical microscope. A photolithographic mask with well-defined shape is inserted as a field stop. Mask designs are made in Wolfram Mathematica and postprocessed in Dassault Systémes’ DraftSight.
10
Photopolymer-based Hydrogel Protocol
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The photopolymer used for the majority of experiments was 0.5% v/v photoinitiator 2-hydroxy-2methyl-1-phenyl-1-propanone (Darocur 1173, Sigma Aldrich) in poly(ethylene glycol) (400) diacrylate (PEG-DA, Sigma Aldrich) in 80% aqueous solution. NGM plates were prepared using standard methods outlined in Brenner et al [13 (link)]. The chemical structure for PEG-DA is shown in S2 Fig Table B in S1 File
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