Spss statistics package version 23

Fisher's exact test and Mann–Whitney U test were used to compare intergroup differences for categorical and continuous variables as appropriate. Univariate and multivariate Cox proportional hazard regression models were used to estimate the hazard ratio. The OS and PFS were estimated using the Kaplan–Meier method, whereas the between-group differences were assessed using the stratified log-rank test. Two-tailed tests with p values < 0.05 were considered statistically significant. Receiver operating curves analysis was applied to identify the optimal cutoff threshold of pleural effusion CD4/CD8 and B cell ratios in predicting survival.
All analyses were performed with the IBM SPSS Statistics package, version 23 (IBM Corporation, Armonk, NY).

To compare intergroup differences for categorical and continuous variables, Fisher’s exact test and Mann–Whitney U test were used, respectively. Two-tailed p values  <  0.05 were considered statistically significant differences. The overall survival (OS) was estimated using the Kaplan–Meier method, whereas the between-group differences were assessed using the stratified log-rank test. OS was analyzed from the start of the third-generation EGFR-TKI treatment to mortality and from rebiopsy to mortality. All analyses were performed with the IBM SPSS Statistics package, version 23 (IBM Corporation, Armonk, NY, USA).

Data was collated and analysed using IBM SPSS Statistics package version 23 (IBM Corporation, New York, US). Data was presented as mean values ± standard deviation (SD) unless stated otherwise. A one-way ANOVA was used to compare healthcare use (number of healthcare visits, number of hospital admissions, number of antibiotic prescriptions and total length of hospital stay (days)) from 6 months before and 6 months after implementation of the pathway. Paired t-tests were used to make comparisons of the same outcomes at 2 time points, within the different malnutrition risk groups. As this is a small service evaluation power calculations were not undertaken to determine sample size. A pragmatic approach was taken to recruit as many suitable individuals within the dietetic resource available.