2100 cd linear accelerator

Manufactured by Agilent Technologies

Sourced in United States

The 2100 CD Linear Accelerator is a laboratory equipment manufactured by Agilent Technologies. It is designed to accelerate charged particles in a linear path using electromagnetic fields.

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Eclipse version 8, by Agilent Technologies (1 mentions)

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Linear accelerator

4 protocols using 2100 cd linear accelerator

Validation of Varian 2100C/D Linac Model

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Varian 2100C/D linear accelerator was simulated in MCNPX2.4. Open literature[8 ] data and manufacturer blueprints were used in the simulation set up. Extra care was given while modeling the flattening filter to increase the MC model dose calculations accuracy in large photon fields (sizes >20 cm × 20 cm). Pena, et al.'s method[9 (link)] was used to tune electron beam energy incident on the target. 2 × 10⁹ histories were run and a photon electron energy deposition mesh tally was used to calculate the dose in a simulated water phantom. The cut-off energy of the electrons was 0.2 MeV in all simulations.
To validate the linac simulations, profiles and percent depth dose (PDD) curves for varying field sized were measured using a Physikalisch-Technische Werkstatten (PTW) farmer-type 0.6 cc ion chamber in a water tank. The measured profiles and PDDs were compared to the data from the linac simulations.

Ezzati A.O., Studenski M.T, & Gohari M. (2021). Spatial Mesh-Based Surface Source Model for the Electron Contamination of an 18 MV Photon Beams. Journal of Medical Physics, 45(4), 221-225.

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Tumor Irradiation with Electron Beam

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A Varian 2100 CD Linear Accelerator was used to deliver a uniform tumor dose of 15 Gy or 8 Gy to anesthetized mice. The beam was a 6 MeV electron beam with an SSD of 100 cm, encompassing the entire tumor, and a 2 mm peritumor region. The 3 x 8 Gy treatment was given on consecutive days.

Duval K.E., Wagner R.J., Beiss V., Fiering S.N., Steinmetz N.F, & Hoopes P.J. (2020). Cowpea Mosaic Virus Nanoparticle Enhancement of Hypofractionated Radiation in a B16 Murine Melanoma Model. Frontiers in Oncology, 10, 594614.

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Whole Brain Radiotherapy for Brain Metastases

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Ninety-four patients had WBRT once the diagnosis of BM was confirmed. For WBRT, each patient was simulated in the supine position in a customized thermoplastic immobilization mask. Three-dimensional conventional radiotherapy (3D-CRT) was delivered using a 2100 C/D linear accelerator (Varian Medical Systems, Palo Alto, CA, USA) for 57 patients. The remaining 37 patients were treated by intensity-modulated radiotherapy (IMRT) either with a Hi-Art helical tomotherapy unit, version 2.2.4.1 (TomoTherapy, Inc., Madison, WI, USA), or Eclipse, version 8.6 (Varian Medical Systems Inc., Palo Alto, CA, USA). For the 37 patients who had a boost dose to their BM, the tumor and boost beams were combined in one integrated treatment plan. Fractionation schemes were as follows: 30 Gy in 10 fractions with or without a simultaneous boost to the brain of 45 Gy, or 37.5 Gy in 15 fractions with or without a simultaneous boost to the brain of 45 Gy. The decision whether to give a RT dose boost to the BM sites was at the discretion of each radiation oncologist. The mean radiation dose was 3781 ± 749 cGy to BM.

Chen C.H., Lee H.H., Chuang H.Y., Hung J.Y., Huang M.Y, & Chong I.W. (2019). Combination of Whole-Brain Radiotherapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Improves Overall Survival in EGFR-Mutated Non-Small Cell Lung Cancer Patients with Brain Metastases. Cancers, 11(8), 1092.

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Tumor Irradiation in Mice Using Varian 2100 CD

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Following a computerized treatment and delivery plan, a Varian 2100 CD Linear Accelerator was used to deliver a uniform 6 MeV tumor dose of 15Gy (SSD = 100 cm). The treatment encompassed the entire tumor and a 2 mm peritumor region. Mice were anesthetized with isoflurane for treatment and positioned using conventional radiation oncology laser beam location techniques.

Duval K.E., Tavakkoli A.D., Kheirollah A., Soderholm H.E., Demidenko E., Lines J.L., Croteau W., Zhang S.C., Wagner R.J., Aulwes E., Noelle R.J, & Hoopes P.J. (2023). Enhancement of Radiation Therapy through Blockade of the Immune Checkpoint, V-domain Ig Suppressor of T Cell Activation (VISTA), in Melanoma and Adenocarcinoma Murine Models. International Journal of Molecular Sciences, 24(18), 13742.

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