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Remdesivir rdv

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Remdesivir (RDV) is a broad-spectrum antiviral agent that acts as a nucleotide analog. It is designed to inhibit viral RNA-dependent RNA polymerase, an enzyme essential for viral replication.

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Lab products found in correlation

Ammonium chloride nh4cl, by MedChemExpress (2 mentions) Ribavirin rbv, by Merck Group (2 mentions) Dipyridamole, by Merck Group (1 mentions) Dihydroorotic acid, by Merck Group (1 mentions) Orotic acid, by Merck Group (1 mentions) Uridine, by Merck Group (1 mentions) Brequinar, by Merck Group (1 mentions) Ebselen, by MedChemExpress (1 mentions) Nafamostat mesylate, by MedChemExpress (1 mentions) Camostat mesylate, by MedChemExpress (1 mentions) Boceprevir, by MedChemExpress (1 mentions) Erythromycin, by MedChemExpress (1 mentions) Clindamycin, by MedChemExpress (1 mentions) Azithromycin, by MedChemExpress (1 mentions) Midecamycin, by MedChemExpress (1 mentions) Acetylspiramycin, by MedChemExpress (1 mentions) Clarithromycin, by MedChemExpress (1 mentions) Chloroquine cq, by Merck Group (1 mentions)

3 protocols using remdesivir rdv

1

Synthesis and Evaluation of DHODH Inhibitors

Cited 1 time
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The hDHODH inhibitors (Figure 1A) were synthesized as described previously [16 (link),17 (link)]. Brequinar, uridine, orotic acid (ORO), dihydroorotic acid (DHO), and dipyridamole (DPY) were purchased from Sigma-Aldrich. Remdesivir (RDV) (GS-5734) was obtained by MedChemExpress.
Calistri A., Luganini A., Mognetti B., Elder E., Sibille G., Conciatori V., Del Vecchio C., Sainas S., Boschi D., Montserrat N., Mirazimi A., Lolli M.L., Gribaudo G, & Parolin C. (2021). The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses. Microorganisms, 9(8), 1731.
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2

SARS-CoV-2 Inhibition Assay using Cellular Enzymes

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The compound antipain (i.e., omicsynin B4) was purchased from the Efebio Inc. (Shanghai, China) and the purity was above 97% based on HPLC. The inhibitors in this study were used as follows. Ribavirin (RBV) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Camostat mesylate, nafamostat mesylate, E−64d, remdesivir (RDV), ammonium chloride (NH4Cl), hexa-D-arginine, bivalirudin TFA, argatroban monohydrate, ebselen and boceprevir were purchased from MedChemExpress (Monmouth Junction, NJ, USA). All of compounds were greater than 95% purity and prepared in DMSO, and the concentrations were described in the figure legends.
Human CTSL expression plasmid (pCMV3-CTSL) and empty control vector (pCMV3) were purchased from Sino Biological Inc. (Beijing, China). pcDNA3.1(+)-TMPRSS2, pcDNA3.1(+)-Furin and pcDNA3.1(+) empty control vector were synthesized and provided by Genscript Inc. (Nanjing, China).
Li Y., Wang K., Sun H., Wu S., Wang H., Shi Y., Li X., Yan H., Yang G., Wu M., Li Y., Ding X., Si S., Jiang J., Du Y., Li Y, & Hong B. (2023). Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2. Antiviral Research, 214, 105606.
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3

Antiviral Compound Screening Protocol

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Carrimycin was provided by Shenyang Tonglian Group Co., Ltd. (Shenyang, China). Clarithromycin, midecamycin, erythromycin, roxithromycin, acetylspiramycin, azithromycin, clindamycin, remdesivir (RDV), and ammonium chloride (NH4Cl) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Ribavirin (RBV) and chloroquine (CQ) were purchased from Sigma–Aldrich (St. Louis, MO, USA).
Yan H., Sun J., Wang K., Wang H., Wu S., Bao L., He W., Wang D., Zhu A., Zhang T., Gao R., Dong B., Li J., Yang L., Zhong M., Lv Q., Qin F., Zhuang Z., Huang X., Yang X., Li Y., Che Y, & Jiang J. (2021). Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2. Acta Pharmaceutica Sinica. B, 11(9), 2850-2858.
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