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Ory 1001

Manufactured by Cayman Chemical
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ORY-1001 is a laboratory instrument designed for the analysis and quantification of organic compounds. It utilizes various analytical techniques, such as spectrophotometry, to provide accurate measurements of sample compositions. The core function of ORY-1001 is to assist researchers and scientists in the identification and quantification of organic substances within their experiments or investigations.

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Lab products found in correlation

Gsk lsd1, by GlaxoSmithKline (1 mentions) S2101, by Merck Group (1 mentions) Nod scid mice, by Charles River Laboratories (1 mentions) Og l002, by Selleck Chemicals (1 mentions) Nifedipine, by Merck Group (1 mentions) Picrotoxin, by Merck Group (1 mentions) Bicuculline, by Merck Group (1 mentions) Mefloquine, by Merck Group (1 mentions) D apv, by Merck Group (1 mentions) Tranylcypromine tcp, by Merck Group (1 mentions) Phospho nf kb p65, by Cell Signaling Technology (1 mentions) Tumor necrosis factor (tnf), by Thermo Fisher Scientific (1 mentions) M csf, by Thermo Fisher Scientific (1 mentions) Torin 1, by Cayman Chemical (1 mentions) Swine anti rabbit immunoglobulins hrp, by Agilent Technologies (1 mentions) Hif1a, by Cell Signaling Technology (1 mentions) Sp 2509, by Cayman Chemical (1 mentions) C myc, by BioLegend (1 mentions) Srankl, by Thermo Fisher Scientific (1 mentions) Phospho 4ebp1, by Cell Signaling Technology (1 mentions)

5 protocols using ory 1001

1

Evaluation of LSD1 Inhibitors in Research

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GSK-LSD1 (CAS #2102933–95-7), SP-2577 (CAS #1423715–37-0), and IMG-7289 (CAS #1990504–72-7) were provided by GlaxoSmithKline, Salarius Pharmaceuticals, and Imago BioSciences, respectively through materials transfer agreements. TCP and RN-1 were purchased through Enzo Life Sciences (Farmingdale, NY) and Cayman Chemical (Ann Arbor, MI). ORY-1001 and ORY-2001 were purchased through Cayman Chemical (Ann Arbor, MI) and MedChemExpress (Monmouth Junction, NJ). All LSD1 inhibitors were diluted per manufacturer’s instructions, aliquoted into single-use vials, and stored at −80°C. Table 1 illustrates the chemical structures for LSD1 inhibitors utilized in this study.
Stitzlein L.M., Gangadharan A., Walsh L.M., Nam D., Espejo A.B., Singh M.M., Patel K.H., Lu Y., Su X., Ezhilarasan R., Gumin J., Singh S., Sulman E., Lang F.F, & Chandra J. (2023). Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles. Frontiers in Neurology, 14, 1112207.
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2

ORY-1001 Injection Improves Maze Memory

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ORY-1001 (Cayman Chemical, 19136) was dissolved in PBS at 1mg/ml by vortexing. Mice at 17–20 g body weight were injected 9.0 μg/kg/day; mice at 20–28g body weight were injected 10.0 μg/kg/day. Adult animals were injected for 14 consecutive days followed by a non-match to sample T-maze task. During the behavior task, mice were injected with the same dose at 6 pm daily.
Mukai J., Cannavò E., Crabtree G.W., Sun Z., Diamantopoulou A., Thakur P., Chang C.Y., Cai Y., Lomvardas S., Takata A., Xu B, & Gogos J.A. (2019). Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice. Neuron, 104(3), 471-487.e12.
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3

Pharmacokinetics of LSD1 Inhibitor Derivatives

Cited 1 time
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LSD1 inhibitors used in this study include RN-1 (Calbiochem, San Diego, CA), ORY-1001 (Cayman Chemical, Ann Arbor, MI), OG-L002 (Selleck Chemicals, Houston, TX), S2101 (Millipore, Temecula, CA) and two N-alkylated derivatives of S2101, S2116 and S2157 (synthesized by Tokyo Chemical Industry, Tokyo, Japan) (15 (link)). A pharmacokinetic study was conducted with a single intraperitoneal injection of either S2116 or S2157 at 50 mg/kg to nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice (Charles River Laboratories, Wilmington, MA), followed by serial sampling of blood at 1, 2, 4, 8 and 24 hours after administration. Brain tissues were harvested at 0.5 hour and homogenized in deionized water. Plasma and brain samples were subjected to LC-MS/MS analysis to determine the concentrations of each drug.
Saito S., Kikuchi J., Koyama D., Sato S., Koyama H., Osada N., Kuroda Y., Akahane K., Inukai T., Umehara T, & Furukawa Y. (2018). Eradication of central nervous system leukemia of T-cell origin with a brain-permeable LSD1 inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(5), 1601-1611.
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4

Synaptic and Ion Channel Modulation

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Synaptic and ion channel inhibition experiments were performed with bicuculline (10 μM, Cat# 14340, Sigma), picrotoxin (10 μM, Cat# P1675, Sigma), NBQX (10 μM, Cat# N183, Sigma), D-APV (40 μM, Cat# A8054, Sigma), Nifedipine (10 μM, Cat# N7634, Sigma), TTX (1 μM, Cat# 1078, Tocris) and Mefloquine (25 μM, Cat# M2319, Sigma). The rescue experiments were performed with Tranylcypromine (TCP, 600 nM, Sigma, P8511) and ORY-1001 (0.6–0.9 nM, Cayman Chemical, 19136). All the compounds were added to the culture media as described in the results.
Rabadan M.A., De La Cruz E.D., Rao S.B., Chen Y., Gong C., Crabtree G., Xu B., Markx S., Gogos J.A., Yuste R, & Tomer R. (2022). An in vitro model of neuronal ensembles. Nature Communications, 13, 3340.
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5

Evaluating M-CSF, RANKL, and TNF Signaling

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Human and murine M-CSF, sRANKL, and TNF were purchased from Peprotech (Rocky Hill, NJ, USA). Inhibitors, SP2509, RN-1, ORY-1001, and Torin1, were purchased from Cayman Chemical Company (Ann Arbor, MI). The antibodies used were as follows: LSD1, phospho-NFkB p65, Phospho-4E-BP1, HIF1a, E2F1, PHD-2 (Cell Signaling Technologies, Danvers, MA), p38, c-Myc (BioLegend, San Diego, California) and Swine Anti-Rabbit Immunoglobulins/HRP (DAKO, Hovedstaden, Denmark).
Doi K., Murata K., Ito S., Suzuki A., Terao C., Ishie S., Umemoto A., Murotani Y., Nishitani K., Yoshitomi H., Fujii T., Watanabe R., Hashimoto M., Murakami K., Tanaka M., Ito H., Park-Min K.H., Ivashkiv L.B., Morinobu A, & Matsuda S. (2022). LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF-1α and E2F1. Arthritis & rheumatology (Hoboken, N.J.), 74(6), 948-960.
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