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Norquetiapine

Manufactured by Merck Group
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Sourced in United States

Norquetiapine is a laboratory reagent manufactured by Merck Group. It is a chemical compound used in various research and analytical applications. The core function of Norquetiapine is to serve as a reference standard or analytical tool for scientific investigation, without any specific intended use or interpretation provided.

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Lab products found in correlation

Quetiapine, by Merck Group (2 mentions) Tunicamycin, by Merck Group (1 mentions) Thapsigargin, by Merck Group (1 mentions) Gsk2606414, by Merck Group (1 mentions) Desipramine, by Merck Group (1 mentions) Amitriptyline, by Merck Group (1 mentions) Clomipramine, by Merck Group (1 mentions) Maprotiline, by Merck Group (1 mentions) Trifluoperazine, by Merck Group (1 mentions) Desloratadine, by MedChemExpress (1 mentions) Loxapine, by Merck Group (1 mentions) 2 apb, by MedChemExpress (1 mentions) Go 6983, by MedChemExpress (1 mentions) Isrib, by MedChemExpress (1 mentions) U73122, by MedChemExpress (1 mentions) Optima lc ms grade methanol, by Thermo Fisher Scientific (1 mentions) Formic acid, by Thermo Fisher Scientific (1 mentions) Ammonium acetate, by Thermo Fisher Scientific (1 mentions)

3 protocols using norquetiapine

1

Pharmacological Modulation of Cellular Stress

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Thapsigargin (Sigma, T9033), Tunicamycin (Sigma, T7765), Maprotiline (Sigma, M9651), Amoxapine (MedChemExpress, HY-B0991), Desloratadine (MedChemExpress, HY-B0539), Desipramine (Sigma, D3900), Trifluoperazine (Sigma, T8516), Clomipramine (Sigma, C7291), Amitriptyline (Sigma, A8404), Quetiapine (Sigma, Q3638), Olanzapine (MedChemExpress, HY-14541), Doxepin (MedChemExpress, B078), Loxapine (Sigma, L106), NorQuetiapine (Sigma, 07849), dimethyl sulfoxide (DMSO) (Sigma, D8418), 2-APB (MedChemExpress, HYW009724), U-73122 (MedChemExpress, HY13419), Go 6983 (MedChemExpress, HY13689), GSK2606414 (Sigma, 516535), ISRIB (MedChemExpress, HY-12495).
Chen W., Liu P., Liu D., Huang H., Feng X., Fang F., Li L., Wu J., Liu L., Solow-Cordero D.E, & Hu Y. (2022). Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. Nature Communications, 13, 6796.
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2

Paper Spray MS for Drug Analysis

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Drug standards (cocaine, benzoylecgonine (BZE), heroin, 6‐acetylmorphine (6‐AM), cocaine‐d3, benzoylecgonine‐d3 (BZE‐d3), heroin‐d9 and 6‐acetylmorphine‐d3 (6‐AM‐d3)) were prepared from certified reference materials (Cerilliant, Round Rock, TX, USA) and were used to explore the extraction efficiency of paper spray mass spectrometry.
Certified reference materials of quetiapine, norquetiapine and quetiapine‐d8 were obtained from Sigma Aldrich(St Louis, MO, USA) and were used to develop paper spray and LC/MS methods for the analysis of fingerprint samples.
Optima™ LC/MS grade methanol (MeOH), dichloromethane (DCM), acetonitrile (ACN), isopropanol (IPA) and water (H2O) were used to prepare all solutions and solvent mixtures (Fisher Scientific, Madison, WI, USA). Formic acid or ammonium acetate (where applicable) was added to the mobile phase and spray solvents at 0.1% (v/v) or 10 mM (Fisher Scientific), respectively.
Costa C., Frampas C., Longman K.A., Palitsin V., Ismail M., Sears P., Nilforooshan R, & Bailey M.J. (2019). Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two‐step process. Rapid Communications in Mass Spectrometry, 35(Suppl 2), e8553.
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3

Quantification of Antipsychotic Drugs

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Certified reference materials of antipsychotic drugs (CLZ, QTP, OLZ) their respective metabolites (NDMC, norquetiapine (NQTP), N-desmethylolanzapine (DMO)) and deuterated internal standards (IS) (CLZ-d4, QTP-d8, OLZ-d8) were obtained from Sigma Aldrich. Optima™ LC/MS grade acetonitrile (ACN), formic acid (FA), methanol and water were obtained from Fisher Scientific.
Longman K., Frampas C., Lewis H., Costa C., Nilforooshan R., Chambers M, & Bailey M. (2023). Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing. Frontiers in Chemistry, 11, 1245089.
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