Vitamin k menadione

Manufactured by Merck Group

Sourced in United States, Germany

Vitamin K (Menadione) is a fat-soluble vitamin that plays a crucial role in blood coagulation and bone metabolism. It serves as a cofactor for the enzyme that activates several blood clotting factors, enabling proper blood clotting. Vitamin K is also involved in the regulation of calcium levels and the mineralization of bones.

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Lab products found in correlation

Hemin, by Merck Group (2 mentions) Yeast extract, by BD (1 mentions) Metronidazole mnz, by Merck Group (1 mentions) Polyethylene oxide peo, by Merck Group (1 mentions) Brucella broth, by BD (1 mentions) Whitley dg250 workstation, by Don Whitley Scientific (1 mentions)

Close spelling variants of this product

Menadione (430 citations) Vitamin K (51 citations)

2 protocols using vitamin k menadione

Chitosan-PEO Hydrogel for Osteoblast Culture

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Chitosan (CS: Molecule weight: 100,000-300,000 Da, practical amine: 7-12%) was purchased from Polysciences, Inc., USA. polyethylene oxide (PEO, Molecule weight: 400,000 Da), glucose oxidase (GO_x, from Aspergillus niger, 50KU), glutaraldehyde (GA, 25% aqueous solution) and metronidazole (MNZ) were all purchased from Sigma-Aldrich, USA. Osteoblasts used in cells culture study were derived from rats. For antibacterial activity, P. gingivalis ATCC 33277 was grown in Trypticase soy broth (BBL™, BD Company, USA), supplemented with 0.1g (per 100 ml) yeast extract (BD Company, USA), 0.5 mg hemin (Sigma-Aldrich, USA) and 0.1 mg vitamin K (Menadione, Sigma-Aldrich, USA).

Xiao Y., Gong T., Jiang Y., Wang Y., Wen Z.T., Zhou S., Bao C, & Xu X. (2016). Fabrication and Characterization of a Glucose-sensitive Antibacterial Chitosan-Polyethylene Oxide Hydrogel. Polymer, 82, 1-10.

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Antimicrobial Susceptibility of Anaerobic Bacteria

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Five different strains of bacteria were reactivated in enriched in Brucella broth (BD—Heidelberg, Germany) with 1% hemin and 1% vitamin K (menadione) (Sigma-Aldrich, St. Louis, MO, USA), then were seeded in enriched Brucella agar at 37 °C for 48 h in anaerobic chamber Whitley DG250 Workstation (Don Whitley Scientific Limited, Shipley, West Yorkshire, UK).
The susceptibility of F. nucleatum (ATCC 25586), P. micra (ATCC 23195), P. endodontalis (ATCC 35406), P. gingivalis (ATCC 33277) and P. intermedia (ATCC 33563) was determined in planktonic culture by broth microdilution assay accordingly to Clinical and Laboratory Standards Institute (CLSI), standard M11-A7 (2012), to determine the minimum inhibitory concentration (MIC) and minimum microbicide concentration (MMC).

de Sá Assis M.A., de Paula Ramos L., Abu Hasna A., de Queiroz T.S., Pereira T.C., Nagai de Lima P.M., Berretta A.A., Marcucci M.C., Talge Carvalho C.A, & de Oliveira L.D. (2022). Antimicrobial and Antibiofilm Effect of Brazilian Green Propolis Aqueous Extract against Dental Anaerobic Bacteria. Molecules, 27(23), 8128.

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