β crosslaps serum

Manufactured by Roche

β-CrossLaps/serum is a laboratory test that measures the level of a specific type of collagen fragment in the blood. This collagen fragment is released during the natural breakdown of bone, and its measurement provides information about bone turnover.

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Lab products found in correlation

N mid osteocalcin, by Roche (1 mentions) Cobas e601, by Roche (1 mentions) Total p1np, by Roche (1 mentions)

Close spelling variants of this product

β-CrossLaps (6 citations) β-CrossLaps/serum kit (3 citations)

2 protocols using β crosslaps serum

Bone Turnover Biomarker Measurement

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The biomarkers of bone turnover C-telopeptide and osteocalcin were measured by the immunoassays β-CrossLaps/serum and N-MID Osteocalcin (Roche Diagnostics), respectively.

Mawet M., Maillard C., Klipping C., Zimmerman Y., Foidart J.M, & Coelingh Bennink H.J. (2015). Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives. The European Journal of Contraception & Reproductive Health Care, 20(6), 463-475.

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Bone Turnover Markers and Vitamin D

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Fasting serum concentrations of β-Crosslaps (Elecsys β-Crosslaps/serum) and total P1NP (Elecsys total P1NP) were measured with a Modular Biochemical Immunoassay System (Cobas e601, Roche Diagnostics Pty (Ltd.), Johannesburg, South Africa). Serum 25(OH) VitD and parathyroid hormone (PTH) were assessed via chemiluminescent immunoassay (MAGLUMI 4000 Plus, Xinchanye Biomedical Engineering Co., Ltd., Shenzhen, China). The intra-assay CV (coefficients of variation) were 3.5% for β-Crosslaps, 2.6% for total P1NP, < 10% for 25(OH) VitD, and < 5% for PTH, and the inter-assay CVs were 8.4%, 4.1%, < 15%, and < 10%, respectively.

Yu D., Chen W., Zhang J., Wei L., Qin J., Lei M., Tang H., Wang Y., Xue S., Dong J., Chen Y., Xie L, & Di H. (2022). Effects of weight loss on bone turnover, inflammatory cytokines, and adipokines in Chinese overweight and obese adults. Journal of Endocrinological Investigation, 45(9), 1757-1767.

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