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P ace 5000

Manufactured by Beckman Coulter
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The P/ACE™ 5000 is a high-performance capillary electrophoresis system designed for analytical applications. It provides reliable and accurate separation and analysis of a wide range of biomolecules, including proteins, peptides, and nucleic acids.

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P ace mdq, by Beckman Coulter (5 mentions)

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P/ACE (7 citations)

6 protocols using p ace 5000

1

Analyzing Oligomeric Compounds in 96-Well Plates

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Example 5

Analysis of Oligomeric Compounds Using the 96-Well Plate Format

The concentration of oligomeric compounds in each well can be assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products can be evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition is confirmed by mass analysis of the oligomeric compounds utilizing electrospray-mass spectroscopy. All assay test plates are diluted from the master plate using single and multi-channel robotic pipettors. Plates are judged to be acceptable if at least 85% of the oligomeric compounds on the plate are at least 85% full length.

US11180756B2. Morpholino modified oligomeric compounds (2021-11-23). Ionis Pharmaceuticals, Inc. [US]. Inventors: Michael Oestergaard [US], Punit P. Seth [US].
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2

Oligomeric Compound Quality Analysis

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Example 5

Analysis of Oligomeric Compounds Using the 96-Well Plate Format

The concentration of oligomeric compounds in each well can be assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products can be evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition is confirmed by mass analysis of the oligomeric compounds utilizing electrospray-mass spectroscopy. All assay test plates are diluted from the master plate using single and multi-channel robotic pipettors. Plates are judged to be acceptable if at least 85% of the oligomeric compounds on the plate are at least 85% full length.

US10344275B2. Linkage modified oligomeric compounds (2019-07-09). Ionis Pharmaceuticals, Inc. [US]. Inventors: W. Brad Wan [US], Michael T. Migawa [US], Michael Oestergaard [US], Eric E. Swayze [US], Punit P. Seth [US].
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3

Oligomeric Compound Analysis Using 96-Well Plate

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Example 5

Analysis of Oligomeric Compounds Using the 96-Well Plate Format

The concentration of oligomeric compounds in each well can be assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products can be evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition is confirmed by mass analysis of the oligomeric compounds utilizing electrospray-mass spectroscopy. All assay test plates are diluted from the master plate using single and multi-channel robotic pipettors. Plates are judged to be acceptable if at least 85% of the oligomeric compounds on the plate are at least 85% full length.

US10087210B2. Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom (2018-10-02). Ionis Pharmaceuticals, Inc. [US]. Inventors: Thazah P. Prakash [US], Punit P. Seth [US], Eric E. Swayze [US].
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4

Analyzing Oligomeric Compounds Using 96-Well Plates

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 5

Analysis of Oligomeric Compounds Using the 96-Well Plate Format

The concentration of oligomeric compounds in each well can be assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products can be evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition is confirmed by mass analysis of the oligomeric compounds utilizing electrospray-mass spectroscopy. All assay test plates are diluted from the master plate using single and multi-channel robotic pipettors. Plates are judged to be acceptable if at least 85% of the oligomeric compounds on the plate are at least 85% full length.

US11084844B2. Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom (2021-08-10). Ionis Pharmaceuticals, Inc. [US]. Inventors: Thazha P. Prakash [US], Punit P. Seth [US], Eric E. Swayze [US].
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5

Oligomeric Compounds Analysis in 96-Well Format

Check if the same lab product or an alternative is used in the 5 most similar protocols

Example 5

Analysis of Oligomeric Compounds Using the 96-Well Plate Format

The concentration of oligomeric compounds in each well can be assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products can be evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition is confirmed by mass analysis of the oligomeric compounds utilizing electrospray-mass spectroscopy. All assay test plates are diluted from the master plate using single and multi-channel robotic pipettors. Plates are judged to be acceptable if at least 85% of the oligomeric compounds on the plate are at least 85% full length.

US11268094B2. 5′ modified nucleosides and oligomeric compounds prepared therefrom (2022-03-08). Ionis Pharmaceuticals, Inc. [US]. Inventors: Thazha P. Prakash [US], Punit P. Seth [US], Eric E. Swayze [US].
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6

Ethanolic Extraction of Fruit Compounds

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The fruit sample (1 g) was ground completely using a mortar and pestle and placed in 20 ml of 80% ethanol at 70 °C for 10 min. The suspension was clarified by centrifugation for 10 min at 12,000g. Supernatant was filtered through a 0.45-μm filter membrane and measured using the Beckman P/ACE 5000 high-performance capillary electrophoresis (Fullerton, CA, USA) by the method of Liu (2004) .
Yu W., Peng F., Wang W., Liang J., Xiao Y, & Yuan X. (2021). SnRK1 phosphorylation of SDH positively regulates sorbitol metabolism and promotes sugar accumulation in peach fruit. Tree Physiology, 41(6), 1077-1086.
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