Myd88 mice

Manufactured by Charles River Laboratories

Sourced in Japan

MyD88−/− mice are genetically-engineered mice that lack the MyD88 gene. MyD88 is an essential signaling adapter protein involved in the activation of innate immune responses. These mice can be used in research to study the role of MyD88 in various biological processes.

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Lab products found in correlation

C57bl 6j, by Charles River Laboratories (1 mentions) Balb c, by Charles River Laboratories (1 mentions) Ain 93g, by Oriental Yeast (1 mentions) 129 sv mice, by Japan SLC (1 mentions) C57bl 6, by Charles River Laboratories (1 mentions)

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MyD88−/−,

3 protocols using myd88 mice

Murine Model for Immune Pathways

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Specific pathogen-free male ICR wild-type, TLR2−/−, TLR4−/−, TLR9−/−, and MyD88−/− mice were purchased from Charles River Laboratories Japan, Inc. (Yokohama, Japan). The mice were housed under a 12:12-hr light/dark cycle with
lights on at 600 hr in a thermoregulated room maintained at 24 ± 2.0°C. Humidity was maintained in the range of 55 ± 10%, and AIN-93G food (CLEA Japan, Inc., Tokyo, Japan) and water were provided. Dissection was performed at the
age of 8 to 10 weeks. The animals were treated in accordance with Kirin Company’s ethical guidelines for animal care, handling, and termination.

ASHIGAI H., KOMANO Y., WANG G., KAWACHI Y., SUNAGA K., YAMAMOTO R., TAKATA R., MIYAKE M, & YANAI T. (2017). Polysaccharide from black currant (Ribes nigrum L.) stimulates dendritic cells through TLR4 signaling. Bioscience of Microbiota, Food and Health, 36(4), 141-145.

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Immunomodulatory Effects of Genetic Knockout Mice

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All animal care and experimental procedures were performed in accordance with the guidelines of the Committee for Animal Experimentation at Kirin Company. These studies were approved by the Committee for Animal Experimentation at Kirin Company. Mice were kept in a room maintained on a 12:12-h light-dark cycle at a temperature of 23 ± 1 °C. Mice for BM-DCs assays were provided with a standard mouse chow (CE-2; CLEA Japan, Tokyo, Japan) and mice for the in vivo study were provided with AIN-93G (Oriental Yeast, Tokyo, Japan). BALB/c, C57BL/6 J and C57 BL/6 J Tlr4^−/−, Tlr9^−/− and Myd88^−/− mice were obtained from Charles River Laboratories Japan (Kanagawa, Japan). 129/Sv mice were obtained from Japan SLC, Inc. (Shizuoka, Japan).

Kanayama M., Kato Y., Tsuji T., Konoeda Y., Hashimoto A., Kanauchi O., Fujii T, & Fujiwara D. (2018). Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate. Scientific Reports, 8, 3147.

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Mouse Models for Immunology Research

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C57BL/6 and MyD88^−/−mice were purchased from Charles River, Maryland while, TLR2^−/− and pmel (B6.Cg-Thy1/Cy Tg(TcraTcrb)8Rest/J) mice were purchased from the Jackson Laboratory. The IRAK4 kinase dead mice were a generous gift from Dr. Stefanie Vogel and 4-1BB^−/− mice from Dr. Lieping Chen. 4-1BB^−/−pmel and MyD88^−/−pmel mice were obtained by crossing pmel with 4-1BB^−/−and MyD88^−/− mice and crossing offspring over nine generations. All the protocols were approved by the University of Maryland Institutional Animal Care and Use Committee.

Joseph A.M., Srivastava R., Zabaleta J, & Davila E. (2016). Cross-talk between 4-1BB and TLR1–TLR2 signaling in CD8+ T cells regulate TLR2’s costimulatory effects. Cancer immunology research, 4(8), 708-716.

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