Hydrochlorothiazide (HCTZ) was purchased from Sigma-Aldrich (Steinheim, Germany). Ammonium carbonate (AMC) was purchased from Riedel-de Haen (Seelze, Germany). Eudragit® RS100 (referred to as RS100) and Eudragit® RL100 (referred to as RL100) were kindly donated by JJ Degussa Chemical (Thailand) Ltd., Bangkok, Thailand. Microcrystalline cellulose (MCC; Avicel PH101) was obtained from FMC (Philadelphia, USA). Polyvinylpyrrolidone K30 (PVP K30) was obtained from BASF (Thai) Co., Ltd. (Bangkok, Thailand). All other chemicals were of reagent grade or pharmaceutical grade and used without further purification.
Polyvinylpyrrolidone k30 pvp k30
Manufactured by BASF
Sourced in Germany
Polyvinylpyrrolidone K30 (PVP K30) is a water-soluble, synthetic polymer. It is a fine, white to creamy white powder. PVP K30 has a molecular weight of approximately 40,000 g/mol.
Automatically generated - may contain errors
Lab products found in correlation
Poloxamer 407, by BASF (2 mentions)
Poloxamer 188, by BASF (2 mentions)
Hydrochlorothiazide hctz, by Merck Group (1 mentions)
Methanol meoh, by Merck Group (1 mentions)
Hplc grade acetonitrile acn, by Merck Group (1 mentions)
Sodium n hexadecyl sulfate, by Thermo Fisher Scientific (1 mentions)
Tetrahydrofuran thf, by Merck Group (1 mentions)
Soluplus, by BASF (1 mentions)
D α tocopherol polyethylene glycol 1000 succinate tpgs, by BASF (1 mentions)
Phosphate buffered saline tablet, by Merck Group (1 mentions)
Methanol, by Avantor (1 mentions)
Methylcellulose, by Merck Group (1 mentions)
Hplc grade acetonitrile, by Avantor (1 mentions)
Kolliphor rh40, by BASF (1 mentions)
Nicotinamide, by Merck Group (1 mentions)
Succinic acid, by Merck Group (1 mentions)
Saccharin, by Merck Group (1 mentions)
Itraconazole, by BASF (1 mentions)
Fumaric acid, by Merck Group (1 mentions)
Tween 80, by BASF (1 mentions)
6 protocols using polyvinylpyrrolidone k30 pvp k30
1
Formulation and Evaluation of HCTZ Tablets
2
Synthesis and Characterization of Amphiphilic Compounds
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AmB (>95 % purity) was purchased from Cayman Chemical Co. (Ann Arbor, MI). Hydroxypropylmethyl Acetate Succinate 912 (HPMCAS 912) was donated by The Dow Chemical Company (Midland, MI). Polyvinylpyrrolidone K30 (PVP K30) was donated from BASF (Ludwigshafen, Germany). Sodium dodecyl sulfate (12S) was obtained from BASF (Ludwigshafen, Germany). Sodium n-decyl sulfate (10S), sodium n-octyl sulfate (8S), and sodium n-hexadecyl sulfate (16S) were all purchased from Alfa Aesar (Ward Hill, MA). Sodium n-tetradecyl sulfate (14S) and sodium n-octadecyl sulfate (18S) were both purchased from Acros Organics B.V.B.A (Fair Lawn, NJ). Sodium decanoate (C10) and sodium dodecanoate (C12) were both obtained from Tokyo Chemical Industry (Tokyo, Japan). Dimethyl sulfoxide (DMSO), ethanol (EtOH), acetone, tetrahydrofuran (THF), and HPLC grade acetonitrile (ACN) and methanol (MeOH) were obtained from Sigma-Aldrich (St. Louis, MO).
3
Formulation Development of Solid Dispersions
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CLT was obtained from Chemagis Co. Ltd. (Ramat Hovav, Israel). SLS was purchased from Sigma-Aldrich (Saint-Louis, MO, USA). Hydroxypropyl methylcellulose (HPMC.6 cps) was obtained through the courtesy of Richwood Co. (Seoul, Korea). Poloxamer 407, polyvinylpyrrolidone K30 (PVP K30), D-α-tocopherol polyethylene glycol 1000 succinate (TPGS), and soluplus were supplied by BASF Chemicals (Ludwigshafen, Germany). Polyethylene glycol 6000 (PEG 6000) was obtained from Yakuri Pure Chemicals (Tokyo, Japan). All the other chemicals were of analytical grade and were used without further purification.
4
Dehydrated Titrated Extract Characterization
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Dehydrated titrated extract of CA, containing 36–44% of AS and 54–66% of AA or MA, was obtained from Nanning Weikang Pharmaceutical Technology Co. Ltd. Polyvinylpyrrolidone K30 (PVP K30), polyoxyl 35 castor oil, vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64), polyoxyl 40 hydrogenated castor oil (Kolliphor RH40), and poloxamer 188 were obtained from Basf Co. (Ludwigshafen, Germany). Acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol (Carbopol 934NF), polyoxyl 15 hydroxystearate (Kolliphor HS15), tyloxapol, polyoxyl (PEG) 40 stearate, butylene glycol (BG), polysorbate 20, and polysorbate 80 were supplied from Masung & Co. Ltd. (Seoul, Korea). Hypromellose (HPMC E50LV) was acquired from Whawon Pharm Co. Ltd. (Seoul, Korea). Analytical standards of AS, AA, and NA, carboxymethyl cellulose sodium (Na. CMC), lecithin, methylcellulose, and phosphate-buffered saline tablet were purchased from Sigma Chemical Co. (St. Louis, MO, USA). HPLC grade acetonitrile and methanol were purchased from J.T. Baker (Phillipsburg, NJ, USA). All other chemicals were of analytical grade and used without further refinement.
5
Itraconazole Drug Formulation Development
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Itraconazole (BASF AG, Ludwigshafen, Germany), indomethacin (Fluka Chemie AG, Buchs, Switzerland), fumaric acid, succinic acid, nicotinamide, saccharin (Merck KGaA, Darmstadt, Germany), poloxamer 188, poloxamer 407, Tween 80, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), polyvinylpyrrolidone K30 (PVP K30) (BASF SE, Ludwigshafen, Germany), sodium dodecyl sulfate (SDS) (Carl Roth GmbH & Co., Karlsruhe, Germany), hydroxypropylmethylcellulose E5 (HPMC E5) (Colorcon Ltd., Dartford Kent, UK), hydroxypropylcellulose (HPC) (Nisso Chemical Europe, Düsseldorf, Germany),, methanol, ethanol, dichloromethane, tetrahydrofuran, ethyl acetate (Carl Roth GmbH & Co., Karlsruhe, Germany), hydrochloric acid (HCl, Sigma Aldrich Chemie GmbH, Steinheim, Germany), ultrapurified water purified by a Milli-Q-apparatus (Millipore GmbH, Darmstadt, Germany), 0.25-0.35 mm zirkonium beads (SiLibeads®, Sigmund Lindner GmbH, Warmensteinach, Germany).
6
Formulation of Poorly Soluble Drug in PLGA
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Poly(lactic-co-glycolic acid) (PLGA) (lactide:glycolide molar ratio of 75:25, inherent viscosity of 0.2 dl/g) was purchased from PURAC Biomaterials (Gorinchem, The Netherlands). Polyvinylpyrrolidone K30 (PVP K30) (MW 44-54 kDa) was kindly donated by BASF (Ludwigshafen, Germany). The API was a poorly soluble investigational compound provided by Janssen (Beerse, Belgium). Disodium hydrogenphosphate dodecahydrate (Na 2 HPO 4 .12H 2 O) and formic acid were provided by Chemlab (Zedelgem, Belgium). Sodium hydrogenphosphate monohydrate (NaH 2 PO 4 .H 2 O) was supplied by Merck (Darmstadt, Germany). Acros Organics (Geel, Belgium) supplied dimethylformamide (DMF) and ammonium formiate. Polysorbate 80 (Tween 80) was obtained from Alfa Aesar GmbH (Karlsruhe, Germany). Polyethyleneglycol 400 (PEG) was purchased from Fagron (Waregem, Belgium). Dichloromethane (DCM) and acetonitrile (ACN) were provided by Fisher Scientific (Leicestershire, United Kingdom). All solvents used were of HPLC or analytical grade. Ultrapure water was produced with an Elga Maxima system (Elga Ltd. High Wycombe Bucks, United Kingdom).
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