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Capsaicin

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Capsaicin is a chemical compound found in various types of chili peppers. It is a colorless, odorless, and crystalline substance that is commonly used in laboratory settings for research and analysis purposes. Capsaicin is known for its ability to stimulate certain sensory receptors, which can be utilized in various scientific applications.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (4 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (4 mentions) Capsaicin, by Merck Group (2 mentions) Isoflurane anesthesia, by Baxter (1 mentions) Capsaicin, by Thermo Fisher Scientific (1 mentions) Isoflurane, by Baxter (1 mentions)

2 protocols using capsaicin

1

Capsaicin-Induced Nociceptive Behavior

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A capsaicin (Sigma) injection solution was prepared at a concentration of 0.06% (wt/vol) in 10% DMSO (Thermo Fisher Scientific) and PBS (Thermo Fisher Scientific). Under 2% isoflurane anesthesia (Baxter), 20 µl of the capsaicin solution was injected into the hind paw. Mouse behavior was video recorded over a period of 5 min, and the total time the animal displayed nocifensive behavior (paw lifting, licking, flinching and writhing) was assessed.
Stegemann A., Liu S., Retana Romero O.A., Oswald M.J., Han Y., Beretta C.A., Gan Z., Tan L.L., Wisden W., Gräff J, & Kuner R. (2023). Prefrontal engrams of long-term fear memory perpetuate pain perception. Nature Neuroscience, 26(5), 820-829.
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2

Capsaicin-Induced Nociceptive Behavior

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Capsaicin (Sigma) was diluted from a frozen dimethyl sulfoxide (DMSO, Thermo Fisher Scientific) stock solution (50X) with phosphate-buffered saline (PBS, Thermo Fisher Scientific) to obtain a Capsaicin concentration of 0.02% (weight/vol) in 2% DMSO. Animals were briefly anesthetized with 2% isoflurane (Baxter, Germany), and 20 µL of the Capsaicin solution was injected with a 30 G needle subcutaneously into the plantar surface of the hindpaw. Animals were then placed in a transparent box (20 × 20 cm) on an acrylic glass plate, and the total time the animal displayed nocifensive behavior (paw lifting, licking, flinching, writhing) was assessed over a period of 5 min by an experimenter blinded to the treatment condition.
Oswald M.J., Han Y., Li H., Marashli S., Oglo D.N., Ojha B., Naser P.V., Gan Z, & Kuner R. (2022). Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex. Nature Communications, 13, 5014.
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