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Desethylamiodarone d4 hydrochloride

Manufactured by LGC
Sourced in Canada

Desethylamiodarone-d4 hydrochloride is a stable-isotope labeled compound used as an internal standard in analytical methods. It is a structural analog of desethylamiodarone, a metabolite of the drug amiodarone. This compound serves as a reference material to quantify desethylamiodarone in biological samples.

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2 protocols using desethylamiodarone d4 hydrochloride

1

Amiodarone Metabolism Profiling

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Dulbecco’s Modified Eagle’s Medium (DMEM), amiodarone hydrochloride, formic acid, dimethyl sulfoxide (DMSO), α-naphthoflavone, and ketoconazole were purchased from Sigma-Aldrich (St. Louis, MO). Desethylamiodarone hydrochloride, amiodarone-d4 hydrochloride, and desethylamiodarone-d4 hydrochloride were obtained from Toronto Research Chemicals Inc. (Toronto, ON, Canada). Blasticidin S hydrochloride was purchased from Life Technologies (Grand Island, NY). Human microsomes were obtained from BioreclamationIVT (Baltimore, MD). Water and acetonitrile were LC–MS grade and obtained from Fisher Scientific (Pittsburgh, PA).
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2

Quantification of Amiodarone and Metabolites

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Amiodarone hydrochloride, DEA hydrochloride, and the internal standards (amiodarone‐d4 hydrochloride and desethylamiodarone‐d4 hydrochloride) were purchased from Toronto Research Chemicals (Toronto, Canada). All other chemicals were of commercially available analytical reagent grade.
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