Atovaquone was purchased from Molekula (Irvine, CA, USA). Benzyl benzoate and polyethylene glycol (PEG) (average mol weight 200) were purchased from Sigma Chemical Co. (St. Louis, MO, USA). Isopropyl palmitate was purchased from Spectrum Laboratory Products, Inc. (New Brunswick, NJ, USA). Mineral oil, propylene glycol, and oleic acid were purchased from Fisher Scientific (Pittsburgh, PA, USA). Affinisol HPMC HME 15 LV was kindly donated from Dow Pharma & Food Solutions (Midland, MI, USA). Super-refined polysorbate 80-LQ-(MH), super-refined polysorbate 20-LQ-(MH), and super-refined PEG 400-LQ-(MH) were kindly donated from CRODA Inc. (East Yorkshire, UK). Kollidon VA64, Kollidon 30, and Cremophor RH 40 were kindly donated from BASF Corp. (Florham Park, NJ, USA). Capmul MCM NF and Captex 300 NF were kindly donated from Abitec Corp. (Jamesville, Rock County, WI, USA). Capryol 90, Transcutol HP, Labrafac lipophile WL 1349, Labrafil M 2125 CS, and Labrasol were obtained from Gattefosse SAS (Paramus, NJ, USA). All other chemical reagents used were of analytical grade.
Labrafil m 2125 cs
Manufactured by Gattefosse
Sourced in France
Labrafil M 2125 CS is a non-ionic, water-dispersible lipophilic emulsifier. It is a mixture of mono-, di- and triglycerides of linoleic acid and polyethylene glycol.
Automatically generated - may contain errors
Lab products found in correlation
Labrasol, by Gattefosse (14 mentions)
Capryol 90, by Gattefosse (13 mentions)
Labrafil m 1944 cs, by Gattefosse (13 mentions)
Lauroglycol 90, by Gattefosse (10 mentions)
Transcutol hp, by Gattefosse (9 mentions)
Transcutol p, by Gattefosse (7 mentions)
Lauroglycol fcc, by Gattefosse (7 mentions)
Peceol, by Gattefosse (6 mentions)
Labrafac pg, by Gattefosse (5 mentions)
Cremophor rh40, by BASF (4 mentions)
Capryol pgmc, by Gattefosse (4 mentions)
Labrafac lipophile wl 1349, by Gattefosse (3 mentions)
Gelucire 44 14, by Gattefosse (3 mentions)
Labrafac, by Gattefosse (3 mentions)
Kolliphor elp, by BASF (3 mentions)
Kolliphor rh40, by BASF (3 mentions)
Cremophor el, by BASF (3 mentions)
Tween 80, by Merck Group (3 mentions)
Poloxamer 407, by BASF (2 mentions)
Compritol 888 ato, by Gattefosse (2 mentions)
19 protocols using labrafil m 2125 cs
1
Formulation Development of Atovaquone Nanoparticles
2
Atazanavir Solubility Optimization
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Atazanavir was obtained as a generous gift from Sun Pharmaceutical Industries Limited (Gurgaon, India). Labrafil® M1944CS, Labrafil® M2125CS, LabrafacTM WL1349, LabrafacTM PG, LauroglycolTM 90, CapryolTM PGMC, Compritol® 888ATO, Precirol® ATO 5, Solutol HS15®, Glyceryl monostearate, Gelucire® 44/14, and Gelucire® 43/10 were acquired by Gattefosse (Saint Priest, France). Capmul® PG-12 EP/NF, Captex® 100, and Captex® 300 were obtained from Abitech Corporations (Cleveland, OH, USA). The surfactants like span 20, tween 80, and tween 20 were procured from Merck (Hohenbrunn, Germany). Poloxamer 188, Poloxamer 407, and Cremophor RH 40 were acquired from BASF (Mumbai, India). Sesame oil, canola oil, and castor oil were acquired from the central drug house (Mumbai, India). Water, methanol, and acetonitrile for HPLC were procured from Fischer Scientific Co. (Mumbai, India). Purified water used for all experiments was obtained from Milli Q Plus (Millipore, MA, USA). Rest of the chemicals and reagents were procured from S.D. Fine Chemicals Ltd. (Mumbai, India). Freshly prepared buffer solutions were used for all experiments.
3
Cytotoxicity Evaluation of Lipid-Based Formulations
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NAR (purity > 95%), Solutol HS15, Tween 20, Tween 80, Chremophor EL, PEG 400, propylene glycol, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and chitosan (low-molecular weight) were obtained from Sigma Aldrich (St. Louis, MO, USA). Plurol Oleique, Labrafac, Transcutol P, Labrafil M1944 CS, Labrafil M2125 CS, Labrasol, Lauroglycol 90 and Capryol 90 were gifted by Gattefosse, France and Sefsol 218 was gifted by Nikko Chemicals Co. Ltd., Tokyo, Japan. Invitrogen (Carlsbad, CA, USA) supplied Roswell Park Memorial Institute (RPMI)-1640, fetal bovine serum (FBS)-heat-inactivated and antibiotics including other materials for cell culture. Sunflower oil, oleic acid, castor oil and peanut oil were obtained from local suppliers. Deionized water and analytical grade chemicals were used in each step of the experiments, where the chemicals were used without further purification.
4
Optimization of Terconazole Topical Formulations
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Terconazole was supplied as a gift from Marcyrl Pharmaceutical Industries (Cairo, Egypt). Labrafil®M2125 CS, Capryol™90, Labrasol®, Transcutol® HP, Lauroglycol™90 and Maisine™35-1 were kindly donated by Gattefosse (Lyon, France). Miglyol®812 was donated from Cremer Oleo division (Hamburg, Germany). Cremophor®RH40 was donated by BASF (Ludwigshafen, Germany). Captex®8000 was a gift from Abitec Corporation, Janesville. Tween®80, methanol, ethanol, sodium hydroxide, sodium dihydrogen phosphate, sodium lauryl sulphate, glycerin and propylene glycol were obtained from Adwic, El-Nasr pharmaceutical chemicals Co. (Cairo, Egypt). All reagents and solvents used in this study were of analytical grade.
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Terconazole was supplied as a gift from Marcyrl Pharmaceutical Industries (Cairo, Egypt). Labrafil®M2125 CS, Capryol™90, Labrasol®, Transcutol® HP, Lauroglycol™90 and Maisine™35-1 were kindly donated by Gattefosse (Lyon, France). Miglyol®812 was donated from Cremer Oleo division (Hamburg, Germany). Cremophor®RH40 was donated by BASF (Ludwigshafen, Germany). Captex®8000 was a gift from Abitec Corporation, Janesville. Tween®80, methanol, ethanol, sodium hydroxide, sodium dihydrogen phosphate, sodium lauryl sulphate, glycerin and propylene glycol were obtained from Adwic, El-Nasr pharmaceutical chemicals Co. (Cairo, Egypt). All reagents and solvents used in this study were of analytical grade.
5
Simvastatin Lipid Nanoparticle Formulation
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Simvastatin was gifted by Tocris Bio-Techne Mumbai, India. Poloxamer 407 was gifted by BASF, India. Alendronate sodium, D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) were purchased from Sigma-Aldrich Mumbai India. Peanut Oil, Soyabean Oil, Olive Oil, Sesame Oil and Cottonseed Oil were purchased from Research Lab Fine Chem Industries. Labrafil M 2125CS, Capryol PGMC, Labrafac PG, Labrasol and Labrafil M 1944CS was gifted by Gattefosse India. All other reagents used were of analytical reagent grade and were used without further purification.
6
Solubility and Permeability Enhancement of Bioactive Compounds
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AC1497 was obtained from Professor K. Lee (College of Pharmacy, Dongguk University) [5 (link)]. Labrafil M 2125CS, Labrafil M 1944 CS, Capryol 90, Labrasol, and Transcutol HP were provided by Gattefossé (Saint-Priest, Lyon, France). Captex 355, Capmul PG8, and Capmul MCM C8 were procured as a gift from ABITEC Corporation (Janesville, WI, USA). Kolliphor ELP, Kolliphor RH 40, and Solutol HS 15 were provided by BASF (Ludwigshafen, Germany). Dulbecco’s Modified Eagle’s Medium (DMEM), nonessential amino acids, fetal bovine serum (FBS), antibiotics (penicillin-streptomycin), and all other reagents used in cell culture studies were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Other chemicals and solvents were purchased from Merck KGaA (Darmstadt, Germany). All solvents were of high-performance liquid chromatography (HPLC) grade.
Caco-2 cells (human epithelial colorectal adenocarcinoma cells) were purchased from the Korean Cell Line Bank (Seoul, Korea). Caco-2 cells were grown in DMEM containing 10% FBS, 1% nonessential amino acid, and 1% antibiotics. Cells were incubated at 37 °C in an atmosphere of 5% CO2 and 90% relative humidity.
Caco-2 cells (human epithelial colorectal adenocarcinoma cells) were purchased from the Korean Cell Line Bank (Seoul, Korea). Caco-2 cells were grown in DMEM containing 10% FBS, 1% nonessential amino acid, and 1% antibiotics. Cells were incubated at 37 °C in an atmosphere of 5% CO2 and 90% relative humidity.
7
Tolvaptan Formulation Optimization
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Tolvaptan (purity > 98.5%) was provided by Hwail Pharm (Pyeongtaek, Korea). Triethyl citrate, PeceolTM (glyceryl monooleate, type 40), Maisin® CC (glyceryl monolinoleate), Lauroglycol® 90 (propylene glycol monolaurate type II), Lauroglycol® FCC (propylene glycol monolaurate type I), Cremophor® RH40 (PEG-40 hydrogenated castor oil), Capryol® 90 (propylene glycol monocaprylate type II), Labrafil® M 2125 CS (laouroyl polyoxyl-6-glecerides), Labrafil® M 1944 CS (oleoyl polyoxyl-6-glycerides), Labrafac® lipophile WL 1349 (medium-chain triglyceride), Labrasol® (caprylocapryl polyoxyl-8-glycerides), and Transcutol® HP (diethylene glycol monoethyl ether) were obtained from Gattefosse (Saint-Priest, France). Tween (polyethylene glycol sorbitan monolaurate) 20, Tween 40, Tween 80, polyethylene glycol (PEG) 200, PEG 400, castor oil, and oleic acid were purchased from Daejung (Seoul, Korea). Methanol and acetonitrile (HPLC grade) were purchased from Duksan (Seoul, Korea). All other chemicals and reagents were of analytical grade.
8
Naringenin-loaded Topical Formulation
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Naringenin (purity ≥95%), Carbopol 934, Carbopol 940 and Solutol HS15 were procured from Sigma-Aldrich, USA. TRF was purchased from Sime Darby, Malaysia. Other chemicals, such as oleic acid, sunflower oil, olive oil, tween 20, tween 80, triethanolamine and sodium bicarbonate were obtained from Chemical Solutions Sdn. Bhd., Malaysia. Plurol oleique, labrafac, Transcutol P, Transcutol HP, Labrafil M2125 CS, Labrafil M1944 CS, Labrasol and Capryol 90 were gifted by Gattefosse, France for research, whereas Sefsol 218 was gifted from Nikko Chemicals Co. Ltd, Japan. Rest of the chemicals used in this research were of analytical grade.
9
Formulation Development of Sildenafil Citrate
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Sildenafil (base) was supplied by Huons Pharm. Co. (Ansan, South Korea). Polyvinylpyrrolidone (PVP, K30), Solutol HS15 and Cremophor EL were purchased from BASF (Ludwigshafen, Germany). Dextran, polyvinyl alcohol (PVA), hydroxypropyl methylcellulose 2910 (HPMC), pyrogenic silica (HDK N20 Pharma), hydroxypropyl cellulose low viscosity (HPC-L), carboxymethyl cellulose sodium (Na-CMC), poloxamer 188, PEG 4000 and hydroxypropyl beta-cyclodextrin (HP-β-CD) were kindly offered from Hanmi Pharm. Co. (Suwon, South Korea). Soybean oil, sorbitan monooleate (Span 80), olive oil, polysorbate (Tween 80) and corn oil were provided by Daejung Chem. Co. (Siheugn, South Korea). Peceol, Capryol 90 (propylene glycol monocaprylate), Plurol diisosterarique, Labrafil M2125CS, Transcutol HP, Lauroglycol FCC and Labrasol were acquired from Gattefosse (Saint-Priest Cedex, France). Medium-chain triglycerides (Captex 300) were purchased from Abitec (Columbus, OH, USA). Mineral oil and linseed oil were obtained from Samchun Chemical Co. (Pyeongtaek, South Korea). Gelatin and sesame oil were purchased from Wako Chemicals Co. (Tokyo, Japan). All other chemicals and solvents were of reagent grade; they were used with or without further purification.
10
Solubility Enhancement of Pharmaceutical Compounds
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ATV was supplied by Zhejiang Neo-Dankong Pharmaceutical Co Ltd (Taizhou, People’s Republic of China). Capryol 90, Labrafil M 1944 CS, Labrafil M 2125 CS, Lauroglycol 90, Labrafac PG, Labrasol, and Transcutol P were supplied by Gattefosse (Saint Priest, France). Capmul MCM was supplied by Abitec Co (Janesville, WI, USA). Isopropyl myristate was provided by Kanto Chemical Co Inc (Tokyo, Japan). Miglyol 840 was provided by Interlees Ltd (Seongnam, Korea), and Cremophor EL was supplied by BASF (Ludwigshafen, Germany). Tween 20, Tween 80, Brij 30, Tetraglycol, acetic acid, and ammonium acetate were purchased from Sigma-Aldrich (St Louis, MO, USA). Polyethylene glycol 400 was purchased from Duksan Pure Chemical Co Ltd (Ansan, South Korea), and high-performance liquid chromatography (HPLC)-grade acetonitrile and methanol were purchased from JT Baker (Phillipsburg, NJ, USA). All other chemicals used were of analytical grade.
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