4 oh omeprazole

Manufactured by LGC

Sourced in Canada

4-OH-omeprazole is a chemical compound that is a metabolite of the proton pump inhibitor drug omeprazole. It is commonly used as a reference standard in analytical and bioanalytical applications.

Automatically generated - may contain errors

Lab products found in correlation

7 oh coumarin, by LGC (2 mentions) 4 oh bupropion, by LGC (2 mentions) 6 oh paclitaxel, by LGC (2 mentions) 4 oh tolbutamide, by LGC (2 mentions) 3 methoxymorphinan, by LGC (2 mentions) 6 oh chlorzoxazone, by LGC (2 mentions) 1 oh midazolam, by LGC (2 mentions) Horse cytochrome c, by Solarbio (2 mentions)

Spelling variants of this product

Omeprazole (5 citations)

2 protocols using 4 oh omeprazole

Simultaneous Quantification of Probe Drugs

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All probe drugs (phenacetin, coumarin, bupropion, paclitaxel, tolbutamide, omeprazole, dextromethorphan, chlorzoxazone, and midazolam) and one metabolite (acetaminophen) were purchased from the National Institute for the Food and Drug Control (China). Other metabolites (7-OH-coumarin, 4-OH-bupropion, 6-OH-paclitaxel, 4-OH-tolbutamide, 4-OH-omeprazole, 3-methoxymorphinan, 6-OH-chlorzoxazone, and 1-OH-midazolam) were obtained from Toronto Research Chemicals, Inc. (Canada). Reduced nicotinamide adenine dinucleotide phosphate and horse cytochrome C were obtained from Solarbio Science and Technology co. (China). Methanol and acetonitrile were HPLC grade and were purchased from Siyou Chemical Reagent Co. (China).

Gao J., Wang J., Gao N., Tian X., Zhou J., Fang Y., Zhang H.F., Wen Q., Jia L.J., Zou D, & Qiao H.L. (2017). Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs. Bioscience Reports, 37(6), BSR20171161.

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CYP-Mediated Metabolism Evaluation

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All probe drugs and part metabolites used in this work were purchased from the National Institute for the Food and Drug Control (China), including phenacetin, coumarin, bupropion, paclitaxel, tolbutamide, omeprazole, dextromethorphan, chlorzoxazone, midazolam and paracetamol (phenacetin metabolite). Other metabolites (7-OH-coumarin, 4-OH-bupropion, 6-OH-Paclitaxel, 4-OH-tolbutamide, 4-OH-omeprazole, 3-methoxymorphinan, 6-OH-chlorzoxazone and 1-OH-midazolam) were obtained from Toronto Research Chemicals, Inc. (Canada). Methanol and acetonitrile were HPLC grade and were purchased from Siyou Chemical Reagent Co. (China). Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and horse cytochrome C were obtained from Solarbio Science and Technology co. (China).

Zhang H., Gao N., Tian X., Liu T., Fang Y., Zhou J., Wen Q., Xu B., Qi B., Gao J., Li H., Jia L, & Qiao H. (2015). Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo. Scientific Reports, 5, 17671.

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