Ctx 0294885

Manufactured by GE Healthcare

The CTx-0294885 is a laboratory equipment product manufactured by GE Healthcare. It is designed for clinical and research applications that require accurate and reliable data collection. The core function of this product is to perform data acquisition and analysis tasks, but specific details about its intended use are not provided.

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Lab products found in correlation

Ech sepharose 4b, by GE Healthcare (2 mentions) Carboplatin, by Selleck Chemicals (1 mentions) A 674563, by Selleck Chemicals (1 mentions) Eah sepharose 4b, by GE Healthcare (1 mentions) Sorafenib, by Selleck Chemicals (1 mentions) Gdc 0941, by Selleck Chemicals (1 mentions) Ly3009120, by Selleck Chemicals (1 mentions) Trametinib, by Selleck Chemicals (1 mentions) Bix02189, by Selleck Chemicals (1 mentions) Bortezomib, by Selleck Chemicals (1 mentions)

2 protocols using ctx 0294885

Compound Synthesis and Immobilization

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A-674563, Carboplatin, FRAX1036, and PF-03758309 were purchased from Selleckchem. BDP5290 and BDP9066 were purchased from Glixx Labs and ProbeChem respectively (Data file S10). For the compounds utilized in MIB synthesis, Purvalanol B was purchased from Abcam. PP58 (42 (link)) and VI16832 (43 (link)) were custom synthesized according to previously described methods by The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, P.R. China. CTx-0294885 (44 (link)) was purchased from MedKoo Biosciences, Inc (406457). Conjugation of inhibitors to beads was performed by carbodiimide coupling to ECH Sepharose 4B (CTx-0294885, VI16832 and PP58) or EAH Sepharose 4B (purvalanol B) (GE Healthcare).

Kurimchak A.M., Herrera-Montavez C., Brown J., Johnson K.J., Sodi V., Srivastava N., Kumar V., Deihimi S., O’Brien S., Peri S., Mantia-Smaldone G.M., Jain A., Winters R.M., Cai K.Q., Chernoff J., Connolly D.C, & Duncan J.S. (2020). Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. Science signaling, 13(619), eaax8238.

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Inhibitor Conjugation and Characterization

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BIX02189, bortezomib, GDC-0941, trametinib, LY3009120, and sorafenib were purchased from Selleckchem, and JQ1 was purchased from ApexBio. PP58 (15 (link)) and VI16832 (16 (link)) were custom synthesized according to previously described methods by The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, P.R. China. CTx-0294885 (17 (link)) was purchased from Medkoo. Conjugation of inhibitors to beads was performed by carbodiimide coupling to ECH Sepharose 4B (CTx-0294885, VI16832 and PP58) or EAH Sepharose 4B (purvalanol B) (GE Healthcare).

Kurimchak A.M., Shelton C., Herrera-Montávez C., Duncan K.E., Chernoff J, & Duncan J.S. (2019). Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer. Molecular cancer research : MCR, 17(8), 1721-1734.

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