Amoxicillin trihydrate (AMT) of analytical grade was obtained from Thermo Fisher Kandel GmbH (Karlsruhe, Germany), poloxamer (Kolliphor® P407) was purchased from BASF (Ludwigshafen, Germany). Bovine serum albumin (BSA, lyophilized powder, purity ≥ 97%),ethanol 96% v/v, mucin from porcine stomach (Type III), and all reagents were purchased from Merck Ltd. (Budapest, Hungary) if not indicated otherwise. Sodium hyaluronate (NaHA, Mw = 1400 kDa) was donated from Gedeon Richter Plc (Budapest, Hungary). Analytical-grade methanol was purchased from Molar Chemicals (Budapest, Hungary). Purified water was filtered using the Millipore Milli-Q® (Merck Ltd., Budapest, Hungary) Gradient Water Purification System. All other solvents and reagents used in this study were of pharmaceutical grade.
Kolliphor p407
Manufactured by BASF
Sourced in Germany, United States, India, Indonesia
Kolliphor® P407 is a non-ionic polyoxyethylene-polyoxypropylene block copolymer that is widely used as a surfactant, emulsifier, and solubilizer in various pharmaceutical, cosmetic, and industrial applications. It is a thermosensitive polymer that can undergo reversible sol-gel transition, making it useful for the formulation of controlled-release drug delivery systems.
Automatically generated - may contain errors
Lab products found in correlation
Kolliphor p188, by BASF (11 mentions)
Kollidon va64, by BASF (4 mentions)
Tween 80, by Merck Group (4 mentions)
Formic acid, by Thermo Fisher Scientific (4 mentions)
Poloxamer 407, by BASF (3 mentions)
Soluplus, by BASF (3 mentions)
Calcium chloride dihydrate, by Merck Group (2 mentions)
Chloramphenicol antibiotic, by Bio Basic (2 mentions)
Benzalkonium chloride, by Merck Group (2 mentions)
Sodium bicarbonate, by Merck Group (2 mentions)
Sodium chloride (nacl), by Merck Group (2 mentions)
Parteck mxp, by Merck Group (2 mentions)
Cab o sil 530, by Cabot (2 mentions)
Porcine gastric mucin type 2, by Merck Group (2 mentions)
Lipofectamine rnaimax transfection reagent, by Thermo Fisher Scientific (2 mentions)
Methanol, by Thermo Fisher Scientific (2 mentions)
Milli q, by Merck Group (1 mentions)
Dulbecco s modified eagle s medium dmem, by Thermo Fisher Scientific (1 mentions)
Hanks balanced salt solution (hbss), by Thermo Fisher Scientific (1 mentions)
Poloxamer p407, by BASF (1 mentions)
38 protocols using kolliphor p407
1
Formulation and Characterization of Amoxicillin Trihydrate Hydrogel
2
Poloxamer-Based Intranasal Ketamine Formulations
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Example 1
18 g of poloxamer 407 (Kolliphor P407®, BASF) were dissolved under cold conditions, in 100 ml of water, then 9.23 g of ketamine hydrochloride (i.e. 8 g of ketamine) were added and dissolved while stirring for approximately one hour.
The solution (F1) obtained gels on contact with the mucous membranes of the buccal cavity.
The formulations F2 to F7 reported in table I below were prepared according to the same procedure. As regards the formulations F3 and F4, the mucoadhesive agent (alginate) was added beforehand to the solution of poloxamer before addition of the ketamine at a temperature between +40° C. and +70° C.
3
Poloxamer-Chitosan Ophthalmic Formulations
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Poloxamers P407 (Kolliphor P407; EO 98 PO 69 EO 98 ; average molecular weight (M w ) 13,498 g/mol) and P188 (Lutrol micro F68; EO 80 PO 27 EO 80 ; average M w 8902 g/mol) were purchased from BASF SE (Ludwigshafen, Germany). More than 90% deacetyled ultrapure PROTASAN™ chitosan salt (Protasan UP CL 214; M w 150,000-400,000 g/mol; viscosity 20-200 mPa  s) (CS) was obtained from NovaMa-trix® (Sandvika, Norway). Timolol maleate (TIMO), dexamethasone (DEX), dorzolamide hydrochloride (DORZO) were kindly donated by TEVA Pharmaceutical Industries Ltd. Tobramycin (TOBRA) standard was purchased from the United States Pharmacopeia (Rockville, MD).
Simulated tear fluid (STF), pH 7.4, was prepared by dissolving the following substances in double-distilled water: KCl (1.4 mg/mL), NaCl (6.8 mg/mL), NaHCO 3 (2.2 mg/mL), and CaCl 2 Â 2H 2 O (0.08 mg/mL). 23 Final step in STF preparation was filtration of solution (Whatman™ membrane filters, 0.2 mm, RC58; GE Healthcare Limited, Buckinghamshire, UK).
Cellulose acetate 0.8 mm membranes for in vitro release (IVR) test (CA 0.8) were obtained from Sartorius Stedim Biotech (G€ ottingen, Germany).
Simulated tear fluid (STF), pH 7.4, was prepared by dissolving the following substances in double-distilled water: KCl (1.4 mg/mL), NaCl (6.8 mg/mL), NaHCO 3 (2.2 mg/mL), and CaCl 2 Â 2H 2 O (0.08 mg/mL). 23 Final step in STF preparation was filtration of solution (Whatman™ membrane filters, 0.2 mm, RC58; GE Healthcare Limited, Buckinghamshire, UK).
Cellulose acetate 0.8 mm membranes for in vitro release (IVR) test (CA 0.8) were obtained from Sartorius Stedim Biotech (G€ ottingen, Germany).
4
Poloxamer-Based Antimicrobial Peptide Formulation
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Poloxamer 407 (Kolliphor® P407; kindly provided by BASF, Ludwigshafen, Germany) and methyl paraben (Fluka, Buchs, Switzerland) were dissolved in 20 mM acetate buffer pH 5.5 in an ice bath for 1–2 h until the polymer was completely dissolved (23 wt% poloxamer 407 and 0.03 wt% methyl paraben). For formulations containing DPK-060 without a nanocarrier, DPK-060 was first dissolved in acetate buffer and then added to the polymer solution while stirring. The final concentrations of poloxamer 407 and methyl paraben were 17 wt% and 0.02 wt%, respectively; the final concentrations of DPK-060 were 0.25 wt%, 0.5 wt%, and 1.0 wt%, corresponding to approximately 1.0 mM, 2.0 mM, and 4.0 mM, respectively.
5
Zein-Based Drug Delivery System
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Ethanol (absolute degree), hydrochloric acid (HCl), sodium chloride (NaCl), monopotassium phosphate (KH2PO4), and sodium hydroxide (NaOH) are common reagents supply. Zein (38 kDa, content in protein 81.9–100%, calculated on a dry basis) and triazolyl blue tetrazolium bromide (MTT) were acquired from Sigma Aldrich (Sto. Louis, MO, USA). Mometasone furoate was kindly provided by Ache Pharmaceuticals (Brazil). Poloxamer P407 (Kolliphor® P 407) was kindly provided by BASF (BTCEurope, Barcelona, Spain). Dulbecco’s Modified Eagle’s Medium (DMEM) and Hanks’ Balanced Salt solution (HBSS) were purchased from Gibco (Waltham, USA). Fetal bovine serum (FBS) was purchased from Biochrom AG (Berlin, Germany). The non-essential amino acid was purchased from Gibco (Paisley, UK). Amicon Ultra filter 100 kDa (Ultracel membrane with 100,000 MWCO, Millipore Corporation, Bedford, MA, USA). Polyethylene terephthalate membrane inserts were purchased from Millicel® Merck (Darmstadt, Germany). Ultrapure water was obtained using a Milli-Q purification system (Merck Millipore). All other solvents and chemicals were of analytical grade or equivalent.
6
Topical Ophthalmic Solution Formulation
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The chemicals used were chloramphenicol antibiotic (Bio Basic Inc., Markham Ontario, Canada), hydroxypropyl methyl cellulose (HPMC) (KERRY, Zhoucun Plant, Shandong, China), calcium chloride dihydrate (Merck, Indonesia), sodium chloride (NaCl) (Merck, Indonesia), sodium bicarbonate (Merck, Indonesia), benzalkonium chloride (Merck, Indonesia), poloxamer 407 (Kolliphor® P 407, BASF Indonesia), aqua pro injection (Ikapharmindo Putramas, Indonesia), 70% ethanol (Ikapharmindo Putramas, Indonesia) and propylenglycol (Ikapharmindo Putramas, Indonesia).
7
Plasticizers for Polyvinyl Alcohol Formulations
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Polyvinyl alcohol 3-82 (Parteck® MXP 3-82) and Polyvinyl alcohol 4-88 (Parteck® MXP 4-88) were supplied by Merck KGaA (Darmstadt, Germany).
With the exception of poloxamer 407 (Kolliphor®P 407, BASF SE, Ludwigshafen, Germany), all other plasticizers used (poloxamer 188 (Parteck® PLX 188), sorbitol (Parteck® SI 150), mannitol (Parteck® M200), PEG 300, PEG 400, PEG 600, PEG 1000, glycerol, triacetin, triethyl citrate) were supplied by Merck KGaA (Darmstadt, Germany).
With the exception of poloxamer 407 (Kolliphor®P 407, BASF SE, Ludwigshafen, Germany), all other plasticizers used (poloxamer 188 (Parteck® PLX 188), sorbitol (Parteck® SI 150), mannitol (Parteck® M200), PEG 300, PEG 400, PEG 600, PEG 1000, glycerol, triacetin, triethyl citrate) were supplied by Merck KGaA (Darmstadt, Germany).
8
Clopidogrel Solid Dispersions Using Hydrophilic Polymers
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In this study, clopidogrel hydrogensulfate (Ph. Eur. 10.0) was used as a model API. Four different hydrophilic polymers: poloxamer 407 (Kolliphor® P407, BASF, Germany), macrogol 6000 (Polyglykol 6000 S, Clariant Export AG, Switzerland), povidone (Kollidon® 30, BASF, Germany), and copovidone (Kollidon® VA 64, BASF, Germany), were used as carriers. Ethanol 96% (v/v) was used as a solvent for SDs preparation by solvent evaporation method. All excipients were of pharmaceutical grade.
Other reagents and chemicals used for the characterization of SDs were of analytical grade. API, excipients, and other reagents and chemicals were kindly provided as a gift from Bosnalijek d.d. (Sarajevo, Bosnia and Herzegovina).
Other reagents and chemicals used for the characterization of SDs were of analytical grade. API, excipients, and other reagents and chemicals were kindly provided as a gift from Bosnalijek d.d. (Sarajevo, Bosnia and Herzegovina).
9
Ganoderic Acid Lipid Nanoparticle Formulation
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Ganoderic acid and DEN were purchased from the Sigma Aldrich (St. Louis, MO). Solid lipids, i.e. Cap MCM C10 were obtained from M/s Gattefosse (La Défense Cedex, France). Phospholipid 90G (PL-90G) was received from Lipoid GmBH (Ludwigshafen, Germany). Poloxamers (Kolliphor® P 188, Kolliphor® P 338, and Kolliphor® P 407) were obtained from BASF (Mumbai, India). Tween 80 was purchased by Fisher Scientific Pvt. Ltd. (Mumbai, India) and procured by us. HPLC grade solvents were procured from local vendors. Alkaline phosphatase (ALP) kit, albumin kit, aspartate transaminase (AST) kit, alanine transferase (ALT) kit, and total protein estimation kit were procured from Span Diagnostics (Surat, India).
10
Characterization of TQM Formulation
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TQM (purity: 98.6%) was purchased from Sigma-Aldrich (USA). BASF, Dhaka, Bangladesh kindly donated Soluplus®, Kolliphor® P188, and Kolliphor® P407. All other chemicals and reagents were purchased commercially.
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