Cine, T1w, T2w, T2∗w, and LGE images were acquired 1 day before and 2, 4, 6, and 8 weeks after cell delivery using a 7-T MR901 Discovery horizontal bore scanner (Agilent Technologies). The following imaging parameters were used for cardiac cine: fast spoiled gradient echo, echo time (TE) 1.5 ms, repetition time (TR) 6–8 ms, flip angle 15°, slice thickness 1 mm, field of view (FOV) 50 × 50 mm2, 20 images per R-R interval, matrix size 192 × 192, and number of signal averages (NSA) 1. For the remaining acquisitions, a slice thickness of 1 mm, FOV 40 × 40 mm2 and a matrix size of 192 × 192 were used with the following imaging parameters: (1) for T1w acquisitions: spin echo, TE 9.7 ms, TR 700 ms, and NSA 4; (2) for T2w acquisitions: spin echo, TE 20 ms, TR 700 ms, and NSA 4; (3) for T2∗w acquisitions: spoiled gradient echo, TE 7 ms, TR 10.3 ms, flip angle 20°, and NSA 3; (4) and for LGE: gradient echo inversion recovery, TE 1.4 ms, TR one breathing interval, inversion time 280–370 ms, flip angle 90°, and NSA 2.
Mr901 discovery
Manufactured by Agilent Technologies
The MR901 Discovery is a versatile laboratory instrument designed for material analysis. It functions as a mass spectrometer, providing accurate measurement and identification of molecular compounds.
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Lab products found in correlation
4 protocols using mr901 discovery
1
Multimodal Cardiac Imaging Protocol for Cell Delivery Assessment
2
Longitudinal MRI of Cell Delivery
3
Monitoring Stem Cell Graft Viability
4
Pre-Clinical DCE-MRI Protocol on 7.0T Scanner
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Imaging was performed on a pre-clinical 7.0T scanner (Discovery MR901, Agilent technologies/GE Healthcare) with the standard imaging gradient set (300 mT/m, slew rate of 1000 mT/m/ms—rise time = 300 μs). A 150-mm transmit coil and four-channel surface coil (5 cm FOV) were used to acquire all images.
DCE-MRI data were acquired following a bolus i.v. injection of Gadobutrol (Gadovist; Bayer Healthcare, Germany). The acquisition parameters used were repetition time (TR) = 10 ms, echo time (TE) = 2 ms, flip angle 12°, matrix size = 116 × 116 and slice thickness = 0.8 mm with a total imaging volume of 50 × 50 × 32 mm3 (x, y, z). Four k-space segments were acquired using a segmented readout sequence called TRICKS [18 (link)]. This resulted in a temporal resolution of 4.7 s. Before contrast administration, four to five time points were acquired to obtain the baseline signal intensity. Prior to acquiring the DCE-MRI image series, a saturation recovery T1 map was acquired using a spin echo sequence with varying TRs, settings: TE = 8 ms, TR = 200, 400, 800 and 1600 ms. T2 maps were also acquired with a spin echo sequence varying TE, settings: TR = 1200 ms, TE = 8, 16, 25 and 35 ms. All mapping images were acquired with slice thickness 0.8 mm, 5 cm FOV and 256 × 256 matrix.
DCE-MRI data were acquired following a bolus i.v. injection of Gadobutrol (Gadovist; Bayer Healthcare, Germany). The acquisition parameters used were repetition time (TR) = 10 ms, echo time (TE) = 2 ms, flip angle 12°, matrix size = 116 × 116 and slice thickness = 0.8 mm with a total imaging volume of 50 × 50 × 32 mm3 (x, y, z). Four k-space segments were acquired using a segmented readout sequence called TRICKS [18 (link)]. This resulted in a temporal resolution of 4.7 s. Before contrast administration, four to five time points were acquired to obtain the baseline signal intensity. Prior to acquiring the DCE-MRI image series, a saturation recovery T1 map was acquired using a spin echo sequence with varying TRs, settings: TE = 8 ms, TR = 200, 400, 800 and 1600 ms. T2 maps were also acquired with a spin echo sequence varying TE, settings: TR = 1200 ms, TE = 8, 16, 25 and 35 ms. All mapping images were acquired with slice thickness 0.8 mm, 5 cm FOV and 256 × 256 matrix.
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