1 5 dicaffeoylquinic

Acetonitrile (hypergrade for LC–MS), formic acid (for LC–MS) and methanol (an-alytical grade) were purchased from Merck (Merck, Bulgaria). The reference standards used for compound identification were obtained from Extrasynthese (Genay, France) for gallic, protocatechuic, p-coumaric, m-coumaric, o-coumaric, vanillic, and salicylic acid, as well as luteolin 7-O-rutinoside, luteolin 7-O-glucoside, isorhamnetin 3-O-glucoside, apigenin 7-O-glucoside, and luteolin. Neochlorogenic, chlorogenic, caffeic, 3,4-dicaffeoylquinic, 3,5-dicaffeylquinic and 1,5-dicaffeoylquinic acids were supplied from Phytolab (Vesten-bergsgreuth, Bavaria, Germany).

Galantamine hydrobromide (Sopharma, Sofia, Bulgaria, Mw = 368.3 g/mol, purity > 98%); Ginkgo biloba capsules 80 mg (Adipharm, Sofia, Bulgaria, dry standardized leaf extract (EGb 761), contains 6% terpenolactones and 24% flavonoid glycosides).
Acetonitrile (hypergrade for LC-MS), formic acid (for LC-MS), and methanol (analytical grade) were purchased from Chromasolv (Sofia, Bulgaria). The reference standards used for compound identification were obtained from Extrasynthese (Genay, France) for protocatechuic, gentisic, p-coumaric, m-coumaric, o-coumaric, syringic, vanillic, and salicylic acids and hyperoside, luteolin 7-O-glucoside, isorhamnetin 3-O-glucoside, luteolin, quercetin, kaempferol, isorhamnetin, and jaceosidin. Neochlorogenic, chlorogenic, caffeic, 3,4-dicaffeoylquinic, 3,5-dicaffeoylquinic, and 1,5-dicaffeoylquinic acids were supplied from Phytolab (Vestenbergsgreuth, Germany).

Acetonitrile (hypergrade for LC–MS), formic acid (for LC-MS), and methanol (analytical grade) were purchased from Chromasolv (Bulgaria). The authentic standards gallic, vanillic, protocatechuic, gentisic, salicylic, p-coumaric, rutin, isoquercitrin, luteolin 7-O-rutinoside, luteolin 7-O-glucoside, isorhamnetin 3-O-glucoside, apigenin 7-O-glucoside, luteolin, quercetin, apigenin, and chrysoeriol were obtained from Extrasynthese (Genay, France). Rosmarinic, caffeic, ferulic, chlorogenic, neochlorogenic, 3,4-dicaffeoylquinic, 3,5-dicaffeoylquinic, 1,5-dicaffeoylquinic, and 4,5-dicaffeoylquinic acid were supplied from Phytolab (Vestenbergsgreuth, Germany). Sonchuside A and 8-acetyl-15β-D -glucopyranosyllactucin were previously isolated and identified by Zidorn et al., 2005 [8 (link)].