500 mhz fourier transform nmr spectrometer

All reactions were carried out under an atmosphere of dry nitrogen. Anhydrous dioxane, CPME, and toluene were purchased from Sigma-Aldrich and used without further purification. THF was dried through activated alumina columns. Unless otherwise stated, all reagents were commercially available and used without further purification. Flash chromatography was performed with silica gel (300–400 mesh). The NMR spectra were obtained using a Brüker 500 MHz Fourier-transform NMR spectrometer. High-resolution mass spectrometry (HRMS) data were obtained on a Waters LC-TOF mass spectrometer (model LCT-XE Premier) using chemical ionization (CI) or electrospray ionization (ESI) in positive or negative mode, depending on the analyte.

All reactions were conducted under an inert atmosphere of dry nitrogen. Anhydrous dioxane, CPME, and 2-MeTHF were purchased from Sigma-Aldrich and used without further purification. Dichloromethane and toluene were dried through activated alumina columns under nitrogen. Unless otherwise stated, reagents were commercially available and used as received without further purification. Chemicals were purchased from Sigma-Aldrich, Acros, or Matrix Scientific and solvents were obtained from Fisher Scientific. Flash chromatography was performed with Silica gel (230–400 mesh, Silicycle). NMR spectra were obtained using a Brüker 500 MHz Fourier-transform NMR spectrometer. The infrared spectra were obtained with KBr plates using a Perkin-Elmer Spectrum 1600 Series spectrometer. High resolution mass spectrometry (HRMS) data were obtained on a Waters LC-TOF mass spectrometer (model LCT-XE Premier) using chemical ionization (CI) or electrospray ionization (ESI) in positive or negative mode, depending on the analyte. Melting points were determined on a Unimelt Thomas-Hoover melting point apparatus and are uncorrected. N,N-diethylacetamide was purchased from Sigma-Aldrich and stored under nitrogen.