Methamphetamine d5

Powdered methamphetamine hydrochloride (Lot #: 098K0693, purity 100 %) and cocaine hydrochloride (Lot #: 028K1165, purity 98.3 %) were purchased from Sigma-Aldrich (St. Louis, MO, USA). A known mass of the powdered drug was weighed out and dissolved in 1 mL of solvent (Optima LC/MS grade water from Fisher Scientific (Pittsburgh, PA, USA) for methamphetamine, Photrex Reagent grade acetone from J. T. Baker for cocaine) to make drug standard solutions. The methamphetamine hydrochloride was used as received and without any further purification. The cocaine hydrochloride was first converted to its freebase form using a slight variation of a method described elsewhere.^{55 (link)} Details of the method used in this work can be found in the Supplemental Information.
Deuterated certified reference materials, methamphetamine-D₅ (1 mg/mL in methanol) and cocaine-D₃ (1 mg/mL in acetonitrile), were purchased from Cerilliant (Round Rock, TX, USA) and used as internal standards. Each deuterated standard was diluted to nominally 1 μg/mL using LC/MS grade methanol (Fisher Scientific). These were subsequently used to create approximately 250 mL of a 10 ng/mL deuterated internal standard in methanol, which was used for the extraction of all aerosol samples, as well as the creation of calibration curves.