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2 protocols using dabigatran etexilate

1

Comprehensive Compound Database for Research

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The following compounds were used in this study: acebutolol (23393, Cayman Chemical, Ann Arbor, MI, USA), adapalene (A2549, Tokyo Chemical Industries, Tokyo, Japan), BIO-acetoxime (16329, Cayman Chemical), caspofugin acetate (15923, Cayman Chemical), celastrol (70950, Cayman Chemical), cepharanthine (19648, Cayman Chemical), colistin sulfate (AG-CN2-0065-M100, Adipogen, San Diego, CA, USA), CP-100356 monohydrochloride (PZ0171, Sigma-Aldrich, Burlington, MA, USA), dabigatran etexilate (17131, Cayman Chemical), desloratadine (16931, Cayman Chemical), diethylstilbestrol (10006876, Cayman Chemical), fluoxetine hydrochloride (CDX-F0141-M010, Adipogen), fluspirilene (19530, Cayman Chemical), methiothepin maleate (23138, Cayman Chemical), mitoxantrone hydrochloride (14842, Cayman Chemical), N-allylthiourea (A0220, Tokyo Chemical Industries), plerixafor hydrochloride hydrate (10011332, Cayman Chemical), proscillaridin A (0852, EXTRASYNTHESE, Genay, France), ranolazine hydrochloride (15604, Cayman Chemical), ruthenium red (14339, Cayman Chemical), and zoxazolamine (320-86751, Wako, Osaka, Japan). Benzyl-α-GalNAc was obtained from Sigma-Aldrich.
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2

Screening of 56 Antischistosomal Compounds

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A total of 56 compounds (Figure S4, Table S4) was selected by both the manual and automated methods for screening
of S. mansoni adults and somules. The following
compounds were purchased from Cayman Chemical: U-73122, BIX01294 hydrochloride
hydrate, tyrphostin AG-1478, sivelestat sodium tetrahydrate, AGK2,
trilostane, itraconazole, dabigatran etexilate, SB202190 hydrochloride,
niflumic acid, amsacrine hydrochloride, R(+)-IAA-94,
piperlongumine, tiamulin fumarate, PNU-282987, tetrabenazine, nemadipine-A,
mycophenolic acid, etravirine, (S)-duloxetine hydrochloride,
moxidectin, and rutecarpine. The following compounds were purchased
from Sigma-Aldrich: clindamycin 2-phosphate, tyrphostin I-OMe-AG-538,
and escabet sodium. The following compounds were purchased from Selleck
Chemicals: revaprazan hydrochloride and Org 27569. The following compounds
were purchased from Enamine: Z385159220, Z18885599, Z276431168, Z2241105867,
Z827016000, Z48867676, Z53005631, Z90192490, Z56174662, Z105384660,
Z44528364, Z827015296, Z304863612, and Z56958732. Finally, the following
compounds were purchased from Toronto Research Chemical: eletriptan
and ondansetron hydrochloride dihydrate. Powders were stored according
to vendor specifications. Compounds were then dissolved at 10 mM in
fresh DMSO and shipped to UCSD on dry ice for storage at −80
°C until use.
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