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Bcs coagulation analyzer

Manufactured by Siemens
Sourced in France

The BCS coagulation analyzer is a laboratory equipment product manufactured by Siemens. It is designed to perform hemostasis tests, which are essential for the assessment of blood clotting factors. The core function of the BCS coagulation analyzer is to analyze and measure the time it takes for blood samples to clot, providing crucial information for clinical diagnosis and monitoring.

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5 protocols using bcs coagulation analyzer

1

Plasma-derived VWF Clearance Study

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Patients II-1 and II-2 were challenged with an intravenous infusion of plasma-derived VWF containing FVIII (Wilate, Octapharma) at 50 IU/kg. VWF antigen, VWF ristocetin cofactor activity, and FVIII activity (i.e., von Willebrand panel) were clinically evaluated at the indicated time points on a Siemens BCS coagulation analyzer by the Clinical Coagulation Laboratory at Boston Children’s Hospital. A similar clearance study of plasma-derived VWF for patient I-1 has been previously reported.25 (link)
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2

Coagulation Markers in Plasma

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Plasma D-dimer and TAT complexes were quantified using the Innovance™ D-dimer test on a BCS™ coagulation analyzer and the Enzygnost™ TAT micro kit, respectively (Siemens Healthcare).
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3

Comprehensive ECC Hemodynamic Monitoring

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Blood samples were obtained from the arterial line. Samples were obtained at baseline (prior to vessel cannulation for ECC) and hourly following initiation of ECC blood flow. Samples obtained were used to determine arterial blood gas values, activated clotting time, white blood cell count, platelet count, platelet aggregation, fibrinogen levels, and thrombin clotting time. Blood gases were analyzed by an ABL 725 blood-gas analyzer and OSM3 Hemoximeter (Radiometer Copenhagen, Copenhagen, DK) with pH, PaCO2, PaO2, and hemoglobin recorded. Activated clotting time was measured by a Hemochron Blood Coagulation System Model 801 (International Technidyne, Edison, NJ). White blood cell and platelet counts were analyzed by a Coulter Counter Z1 (Coulter Electronics, Hialeah, FL). Platelet aggregation was measured by a Chrono-Log Optimal Aggregometer Model 490 (Chrono-Log, Haverton, PA). Plasma fibrinogen concentrations and thrombin clotting times were measured using a Dade Behring BCS Coagulation Analyzer (Siemens, Deerfield, IL).
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4

Measuring Anti-IIa Activity in Plasma Samples

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Laboratory tests were carried out in each participating center using local protocols and methods to support diagnosis and treatment. A centralized laboratory performed clotting time measurements on the frozen plasma samples from all sites on a BCS Coagulation Analyzer (Siemens, Saint-Denis, France) to allow for comparison between patients and methods. Measurement of the aPTT was performed using a PTT automate (Diagnostica Stago, Asnières, France). Anti-IIa activity was determined using ecarin clotting time (ECT) and modified thrombin time (TT). The modified TT was measured using the Hemoclot® thrombin inhibitor assay (Hyphen, Biomed, Neuville, France). The ECT was measured using ecarin, a purified protease, (Diagnostica Stago, Asnières, France) diluted in Hepes 0.025 M CaCl2 buffer at a final concentration of 5 IU/ml. All clotting times were expressed in seconds. ECT and TT measurements were then converted into direct concentration units of argatroban (μg/ml) using the same calibration curve (Hyphen, Biomed, Neuville, France).
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5

Thrombin Clotting Time after ECC

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After 4 h on ECC, thrombin clotting time (TCT) was measured via Siemens BCS coagulation analyzer, the circuits were clamped, removed from animal, rinsed with 60 ml of saline, and drained. Any residual thrombus in the thrombogenicity chamber tubing was photographed and quantitated using Image J imaging software from the NIH (Bethesda, MD). After administration of 400 U/kg of sodium , the animals were euthanized using Fatal Plus (130 mg/kg sodium pentobarbital) (Vortech Pharmaceuticals Dearborn, MI).
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