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Mr750 3 tesla scanner

Manufactured by GE Healthcare

The MR750 3 Tesla scanner is a magnetic resonance imaging (MRI) system manufactured by GE Healthcare. It operates at a field strength of 3 Tesla, which enables high-quality imaging of the body's internal structures. The system's core function is to produce detailed images of the human anatomy for diagnostic purposes.

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8 protocols using mr750 3 tesla scanner

1

Resting-state fMRI of Healthy Volunteers

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The data for each sample were acquired on two identical GE MR750 3-Tesla scanners with 12-channel radiofrequency head coils. The participants fixated on a cross with their eyes open for the scan duration. For the primary sample, a 6-min resting-state scan using a T2*-weighted echo-planar imaging sequence was acquired (repetition time=2000, echo time=30 ms, field of view=22.1 cm, flip angle=75°, 39 slices, resolution=3.3 mm3). The cardiac signals and respiratory information were also recorded. For the validation sample, the data were acquired using an 8-min multi-echo sequence (repetition time=2300 ms, echo time=12.7/31/48 ms, field of view=24 cm, flip angle=90°, 33 slices, resolution=3.75 × 3.75 × 4.2 mm). An identical high-resolution T1-weighted structural image was acquired for both the samples.
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2

High-Resolution MRI Brain Imaging

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High resolution T1-weighted structural images were acquired on one of two identical GE MR750 3 Tesla scanners at the same site, using identical sequences (TR=7.31ms, TE=3.02ms, 256 x 256 matrix, 196 slices, voxel size = 1.2 x 1.05 x 1.05mm).
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3

MRI Acquisition Protocol for Resting-State fMRI

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Structural and resting state functional MRI (rsfMRI) data were acquired on a GE MR 750 3-Tesla scanner using a GE 32 channel head coil. A high-resolution structural image was acquired using a magnetization-prepared rapid-gradient-echo (MP-RAGE) T1-weighted sequence with the following parameters: time to echo [TE] = 3.42 ms; time to repetition [TR] = 7 ms; time to inversion [TI] = 425 ms; flip angle = 7°; Phase Acceleration Factor = 2; slices with 1 × 1 × 1 mm voxels). rsfMRI data were obtained using an axial echo-planar imaging (EPI) sequence (TE = 28.1 ms; TR = 2500 ms; flip angle = 77°; Phase Acceleration Factor = 2; 44 slices, each 3 mm thick, with 2 × 2 mm in-plane voxel resolution). Two runs with 134 volumes for each run were acquired for each participant (Data for the control group were acquired as part of a larger project that is outlined in Barnes et al., 2014 (link)). Physiological variables relating to heart rate and respiration were recorded during scans using a pulse oximeter placed on the left index finger and a pneumatic belt positioned at the level of the diaphragm.
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4

fMRI Analysis of Drug Effects

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fMRI was performed 5 hours after first drug/placebo administration. Data were acquired on a MR750 3-Tesla scanner with a 12-channel head coil (GE Healthcare, Chicago, IL); 180 volumes were acquired per functional run using a T2*-weighted echo-planar imaging sequence (repetition time = 2000 ms, echo time = 30 ms, field of view = 22.1 cm, flip angle = 75°, 41 slices, resolution = 3.3 mm3), with 4 initial volumes discarded to allow for magnetization equilibration effects. Cardiac signals were recorded with a plethysmograph, while respiration was measured using a respiratory belt. A high-resolution T1-weighted image was also acquired (repetition time = 7.31 ms, echo time = 3.02 ms, 256 × 256 matrix, 196 slices, voxel size = 1.2 × 1.05 × 1.05 mm).
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5

Multimodal Neuroimaging Protocol with MEG and MRI

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MEG measurements were carried out using a 306-channel whole-scalp neuromagnetometer system (Elekta TRIUXTM, Elekta Neuromag Oy, Helsinki, Finland). Data were recorded at a 1 kHz sampling rate, on-line bandpass filtered between 0.1 and 330 Hz and stored for off-line analysis. Horizontal eye-movements and eye-blinks were monitored using horizontal and vertical bipolar electrooculography electrodes. Cardiac activity was monitored with bipolar electrocardiography electrodes attached below the left and right clavicle. Internal active shielding was active during MEG recordings to suppress electromagnetic artifacts from the surrounding environment. In preparation for the MEG-measurement, each participant’s head shape was digitized using a Polhemus FASTRAK. The participant’s head position and head movement were monitored during MEG recordings using head-position indicator coils. Anatomical MRIs were acquired using hi-res Sagittal T1 weighted 3D IR-SPGR (inversion recovery spoiled gradient echo) images by a GE MR750 3 Tesla scanner with the following pulse sequence parameters: 1 mm isotropic resolution, FoV 240 × 240 mm, acquisition matrix: 240 × 240, 180 slices 1 mm thick, bandwidth per pixel = 347 Hz/pixel, flip angle = 12 degrees, TI = 400 ms, TE = 2.4 ms, TR = 5.5 ms resulting in a TR per slice of 1390 ms.
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6

Resting-State fMRI with Eyes Open/Closed

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MR images were acquired on a GE MR750 3 Tesla scanner using a standard 8-channel head coil. A high-resolution T1-weighted anatomical image was acquired first. Following this, BOLD imaging was carried out, with the order of these scans counterbalanced across participants. The EO/EC sequence was also counterbalanced across participants and the light in the scanner room was turned off while scanning. As was the case with the Berlin dataset, during both types of scans, participants were instructed to lie still, remain awake and not focus their attention on anything in particular.
For EC runs, participants kept their eyes closed throughout and a black screen was presented to ensure that their exposure to light was minimal. During EO runs, a gray screen was presented. For EO runs, participants were instructed to keep their eyes open and gaze at the screen. After scanning, participants were asked whether they had remained awake; all reported that they had done so.
BOLD-sensitive images were acquired using a T2-weighted EPI sequence (TR = 2000 ms; TE = 30 ms; flip angle = 90°; FOV = 220 mm; matrix = 64 × 64; slice thickness = 3.4 mm; slice gap = 0 mm; 33 slices). 200 volumes were acquired in each run (6.67 min).
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7

Multimodal Neuroimaging Protocol for Brain Mapping

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MEG measurements were carried out using a 306-channel whole-scalp neuromagnetometer system (Elekta TRIUXTM, Elekta Neuromag Oy, Helsinki, Finland). Data was recorded at a 1 kHz sampling rate, on-line bandpass filtered between 0.1-330 Hz and stored for off-line analysis. Horizontal eye-movements and eye-blinks were monitored using horizontal and vertical bipolar electrooculography electrodes. Cardiac activity was monitored with bipolar electrocardiography electrodes attached below the left and right clavicle. Internal active shielding was active during MEG recordings to suppress electromagnetic artefacts from the surrounding environment. In preparation for the MEG measurement, each participant's head shape was digitized using a Polhemus FASTRAK system. The participant's head position and head movement were monitored during MEG recordings using head-position indicator (HPI) coils. Anatomical magnetic resonance images (MRIs) were acquired using hi-res Sagittal T1 weighted 3D IR-SPGR (inversion recovery spoiled gradient echo) images by a GE MR750 3 Tesla scanner, with the following pulse sequence parameters: 1 mm isotropic resolution, FoV 240 × 240 mm, acquisition matrix: 240 × 240, 180 slices 1 mm thick, bandwidth per pixel=347 Hz/pixel, Flip Angle=12 degrees, TI=400 ms, TE=2.4 ms, TR=5.5 ms resulting in a TR per slice of 1390 ms.
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8

3D Pseudo-Continuous ASL Perfusion MRI

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All scans were conducted on a GE MR750 3 Tesla scanner using a 12-channel head coil. ASL image data were acquired using a 3D pseudo-continuous ASL sequence (3DpCASL) with a multi-shot, segmented 3D stack of axial spirals (8-arms) readout with a resultant spatial resolution (after re-gridding and Fourier Transformation) of 2x2x3mm. Four controllabel pairs were used to derive a perfusion weighted difference image. The labelling RF pulse had a duration of 1.5s and a post-labelling delay of 1.5s. The sequence included background suppression for optimum reduction of the static tissue signal. A proton density image was acquired in 48s using the same acquisition parameters in order to compute the CBF map in standard physiological units (ml blood/100g tissue/min). Pre-processing of all CBF data was performed exactly as described in Hawkins et al, (2018) (for further details please see Supplementary Materials).
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