6 oh chlorzoxazone

Manufactured by LGC

Sourced in Canada

6-OH-chlorzoxazone is a chemical compound that can be used as a reference standard or analytical tool in various laboratory applications. It serves as a research tool for the analysis and identification of related compounds.

Automatically generated - may contain errors

Lab products found in correlation

7 oh coumarin, by LGC (2 mentions) 4 oh bupropion, by LGC (2 mentions) 6 oh paclitaxel, by LGC (2 mentions) 4 oh tolbutamide, by LGC (2 mentions) 4 oh omeprazole, by LGC (2 mentions) 3 methoxymorphinan, by LGC (2 mentions) 1 oh midazolam, by LGC (2 mentions) Horse cytochrome c, by Solarbio (2 mentions)

Spelling variants of this product

Chlorzoxazone (2 citations)

2 protocols using 6 oh chlorzoxazone

Simultaneous Quantification of Probe Drugs

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All probe drugs (phenacetin, coumarin, bupropion, paclitaxel, tolbutamide, omeprazole, dextromethorphan, chlorzoxazone, and midazolam) and one metabolite (acetaminophen) were purchased from the National Institute for the Food and Drug Control (China). Other metabolites (7-OH-coumarin, 4-OH-bupropion, 6-OH-paclitaxel, 4-OH-tolbutamide, 4-OH-omeprazole, 3-methoxymorphinan, 6-OH-chlorzoxazone, and 1-OH-midazolam) were obtained from Toronto Research Chemicals, Inc. (Canada). Reduced nicotinamide adenine dinucleotide phosphate and horse cytochrome C were obtained from Solarbio Science and Technology co. (China). Methanol and acetonitrile were HPLC grade and were purchased from Siyou Chemical Reagent Co. (China).

Gao J., Wang J., Gao N., Tian X., Zhou J., Fang Y., Zhang H.F., Wen Q., Jia L.J., Zou D, & Qiao H.L. (2017). Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs. Bioscience Reports, 37(6), BSR20171161.

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CYP-Mediated Metabolism Evaluation

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All probe drugs and part metabolites used in this work were purchased from the National Institute for the Food and Drug Control (China), including phenacetin, coumarin, bupropion, paclitaxel, tolbutamide, omeprazole, dextromethorphan, chlorzoxazone, midazolam and paracetamol (phenacetin metabolite). Other metabolites (7-OH-coumarin, 4-OH-bupropion, 6-OH-Paclitaxel, 4-OH-tolbutamide, 4-OH-omeprazole, 3-methoxymorphinan, 6-OH-chlorzoxazone and 1-OH-midazolam) were obtained from Toronto Research Chemicals, Inc. (Canada). Methanol and acetonitrile were HPLC grade and were purchased from Siyou Chemical Reagent Co. (China). Reduced nicotinamide adenine dinucleotide phosphate (NADPH) and horse cytochrome C were obtained from Solarbio Science and Technology co. (China).

Zhang H., Gao N., Tian X., Liu T., Fang Y., Zhou J., Wen Q., Xu B., Qi B., Gao J., Li H., Jia L, & Qiao H. (2015). Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo. Scientific Reports, 5, 17671.

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