Melting points were determined on a Kofler hot-stage apparatus and are uncorrected. 1H NMR spectra were obtained with a Varian Gemini 200 MHz spectrometer whereas 13C NMR were obtained with a Bruker TopSpin 3.2 400 MHz spectrometer. Chemical shifts (δ) are reported in parts per million (ppm) downfield from tetramethylsilane and referenced from solvent references. The elemental compositions of the compounds agreed to within 0.4% of the calculated value. Chromatographic separation was performed on silica gel columns by flash (Kieselgel 40, 0.040–0.063 mm; Merck). Reactions were followed by thin layer chromatography (TLC) on Merck aluminum silica gel (60 F254) sheets that were visualized under a UV lamp. Evaporation was performed in vacuo (rotating evaporator). Sodium sulfate was always used as the drying agent. Commercially available chemicals were purchased from Sigma-Aldrich.
Topspin 3.2 400 mhz spectrometer
Manufactured by Bruker
The TopSpin 3.2 400 MHz spectrometer is a nuclear magnetic resonance (NMR) instrument designed for chemical analysis. It operates at a frequency of 400 MHz and provides advanced data acquisition and processing capabilities for researchers and analytical chemists.
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2 protocols using topspin 3.2 400 mhz spectrometer
1
Analytical Techniques in Organic Chemistry
2
Characterization of Organic Compounds
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General Material and Methods. Melting points were determined on a Kofler hot-stage apparatus and are uncorrected. Chemical shifts (δ) are reported in parts per million downfield from tetramethylsilane and referenced from solvent references; coupling constants J are reported in hertz. 1 H NMR and 13 C NMR spectra of all compounds were obtained with a Varian Gemini 200
MHz or a Bruker TopSpin 3.2 400 MHz spectrometer. 13 C NMR spectra were fully decoupled.
The Reactions were followed by thin-layer chromatography (TLC) on Merck aluminum silica gel (60 F254) sheets that were visualized under a UV lamp. The microwave-assisted procedures were carried out with a CEM Discover LabMate microwave. Evaporation was performed in vacuo (rotating evaporator). Sodium sulfate was always used as the drying agent. Commercially available chemicals were purchased from Sigma-Aldrich.
MHz or a Bruker TopSpin 3.2 400 MHz spectrometer. 13 C NMR spectra were fully decoupled.
The Reactions were followed by thin-layer chromatography (TLC) on Merck aluminum silica gel (60 F254) sheets that were visualized under a UV lamp. The microwave-assisted procedures were carried out with a CEM Discover LabMate microwave. Evaporation was performed in vacuo (rotating evaporator). Sodium sulfate was always used as the drying agent. Commercially available chemicals were purchased from Sigma-Aldrich.
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