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Nevirapine

Manufactured by Tokyo Chemical Industry
Sourced in Japan

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. It is a chemical compound with a specific molecular structure and properties relevant for its function in the lab.

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2 protocols using nevirapine

1

Anti-HIV Drugs Solubilization Protocol

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Efavirenz and Nevirapine (Tokyo Chemical Industry, Tokyo, Japan) were resolved in dimethyl sulfoxide (DMSO). 3’-Azido-2’,3’-dideoxythymidine-5’-triphosphate (AZT-TP, Jena Bioscience, Jena, Germany) was resolved in nuclease-free distilled water. Raltegravir (Cayman Chemical, Ann Arbor, MI, USA) was resolved in DMSO.
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2

Preparation of Stock Solutions for Cell Culture

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Acetaminophen, tert-butylhydroquinone, and tienilic acid were purchased from Sigma-Aldrich (St. Louis, MO, USA). Aminopyrine, sulfamethoxazole, and forskolin were purchased from Fujifilm Wako Pure Chemical Co. (Osaka, Japan). Erythromycin, valsartan, and warfarin were purchased from LKT Laboratories, Inc. (St Paul, MN, USA). Nevirapine, pravastatin, and procainamide were purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Stock solutions of all test drugs were prepared in dimethyl sulfoxide (DMSO) at a concentration of 200 mM. Each solution was adequately diluted with Dulbecco's modified Eagle's medium (DMEM) (Nissui Pharmaceutical Co., Ltd., Tokyo, Japan) so that the final concentration of DMSO in the culture medium was 0.5%.
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