Thermo ltq xl mass spectrometer

Manufactured by Thermo Fisher Scientific

Sourced in United States

The Thermo LTQ XL mass spectrometer is a high-performance analytical instrument designed for a wide range of applications. It features a linear ion trap technology that provides high sensitivity, resolution, and mass accuracy for the identification and quantification of molecules. The LTQ XL is capable of performing various mass spectrometry techniques such as full-scan, tandem MS, and multiple reaction monitoring.

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Lab products found in correlation

Agilent 1200 liquid chromatograph, by Agilent Technologies (1 mentions) Xcalibur software, by Thermo Fisher Scientific (1 mentions) Diode array detector, by Thermo Fisher Scientific (1 mentions) Hypersil gold, by Thermo Fisher Scientific (1 mentions) Ultimate 3000, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

LTQ XL (192 citations) LTQ mass spectrometer (96 citations) LTQ XL mass spectrometer (76 citations) Thermo LTQ XL (12 citations) Thermo LTQ Orbitrap XL mass spectrometer (12 citations) Thermo LTQ mass spectrometer (9 citations) Thermo Scientific LTQ Orbitrap XL mass spectrometer (3 citations) Thermo Finnigan LTQ XL Ion Trap Mass Spectrometer (2 citations) Thermo LTQ XL Ion Trap Mass Spectrometer (2 citations)

4 protocols using thermo ltq xl mass spectrometer

Capillary HPLC Analysis of PMP-Labeled Monosaccharides

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For PMP-labeled monosaccharide analysis, the capillary HPLC separations were performed using a solvent system composed of acetonitrile (eluent A) and 0.01 M CH₃COONH₄ in water pH 5.5 (eluent B). After injection of 0.5 µl samples, the elution profile was 17% A for 10 min, 19% A for 30 min, 21% A for 15 minutes, and 17% A for 25 minutes. The flow rate was 10 µl per minute, the absorbencies at 245 nm were monitored during each run and the negative ion spectra were collected by using an online Thermo LTQ-XL mass spectrometer.
The same elution condition for capillary HPLC separation of aniline-labeled products was used as described by Lu et al [51] (link). Briefly, an Agilent 1290 series capillary HPLC workstation was coupled with Thermo LTQ-XL mass spectrometer. Negative ion spectra were collected by scanning the m/z range 100–1000. Total ion current chromatograms were collected. The mass spectra were processed with Thermo Xcalibur software.

Zeng Y., Han Z., Qiu P., Zhou Z., Tang Y., Zhao Y., Zheng S., Xu C., Zhang X., Yin P., Jiang X., Lu H., Yu G, & Zhang L. (2014). Salinity-Induced Anti-Angiogenesis Activities and Structural Changes of the Polysaccharides from Cultured Cordyceps Militaris. PLoS ONE, 9(9), e103880.

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Peptide Mapping and Isoaspartic Acid Analysis

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Sample preparation and peptide map separation were carried out as described above, except the eluted peptides were split using an Advion Nanomate fraction collection robot (Advion Biosciences, Ithica, NY, USA). Briefly, the flow was split and 150 nL was analyzed on-line with a Thermo LTQ XL mass spectrometer with ETD capability (Thermo Scientific, Waltham, MA, USA). The remaining volume was collected in a 96-well plate for off-line analysis. The peptide containing isoAsp and the non-isomerized peptide were analyzed by MS using the Nanomate in static-nanospray infusion mode using ETD fragmentation with supplemental activation.

Eakin C.M., Miller A., Kerr J., Kung J, & Wallace A. (2014). Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies. Frontiers in Pharmacology, 5, 87.

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Analytical Instrumentation Protocol

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The tools in our study included an Agilent 1200 liquid chromatograph (quaternary low pressure gradient pump, automatic on-line degasser, autosampler, column oven, and diode array detector, Agilent Technologies, Inc., Waldbronn, Germany), Chem Station workstations (Agilent Technologies, Inc., Waldbronn, Germany), Thermo LTQ XL mass spectrometer (Thermo Fisher Scientific, Inc., San Jose, CA, USA), OHAUS CP214 electronic balance (Ohaus Corporation. Shanghai, China), Mettler Toledo Seven Easy pH meter(Mettler-Toledo International Inc. Shanghai, China), and KH-500 ultrasonic cleaner (Kunshan Wo-invasive Ultrasound Instruments, Inc. Kunshan, Jiangsu, China) were used.

Wang Q., Wu Y., Chen B, & Zhou J. (2015). Drug concentrations in the serum and cerebrospinal fluid of patients treated with cefoperazone/sulbactam after craniotomy. BMC Anesthesiology, 15, 33.

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Phenolic Profiling of W. saharae Extract

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Phenolic composition of hydromethanolic extract of W. saharae was determined using an Ultimate 3000 (Dionex Co., San Jose, CA, USA) apparatus equipped with a binary pump, an automatic sampler, and a diode array detector (Dionex Co., San Jose, CA, USA). The MS analysis was performed using a Thermo LTQ XL mass spectrometer (Thermo Scientific, San Jose, CA, USA), which was equipped with an electrospray ionization interface (ESI). The separation was carried out with a Hypersil Gold (Thermo Scientific, USA) C18 column (100 mm length; 2.1 mm i.d.; 1.9 μm particle diameter, end-capped) at room temperature 25 °C. The extract was prepared at a 1 mg/mL concentration and the injection volume was 10 µL. The solvents used were formic acid in water (A) and acetonitrile (B). The flow rate was set at 2 mL/min. Spectra were recorded in negative mode. MS and MS/MS data were processed using the Thermo Xcalibur Qual Browser data system (Thermo Scientific, USA).

Rechek H., Haouat A., Hamaidia K., Allal H., Boudiar T., Pinto D.C., Cardoso S.M., Bensouici C., Soltani N, & Silva A.M. (2021). Chemical Composition and Antioxidant, Anti-Inflammatory, and Enzyme Inhibitory Activities of an Endemic Species from Southern Algeria: Warionia saharae. Molecules, 26(17), 5257.

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