Discovery ls pet ct

Manufactured by GE Healthcare

Sourced in United States

The Discovery LS PET/CT is a diagnostic imaging system designed to perform both positron emission tomography (PET) and computed tomography (CT) scans. It combines these two imaging modalities to provide comprehensive information about the patient's health.

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Lab products found in correlation

Matlab, by MathWorks (1 mentions) Advance pet, by GE Healthcare (1 mentions) Ecat hr, by Siemens (1 mentions) Discovery ste pet ct, by GE Healthcare (1 mentions)

Close spelling variants of this product

GE Discovery LS PET/CT system Discovery LS PET/CT scanner GE Discovery LS PET/CT GE Discovery LS PET/CT scanner Discovery LS PET/CT system Discovery LS

5 protocols using discovery ls pet ct

Standardized [18F]FDG-PET Imaging Protocol

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All subjects underwent an [18F]FDG–PET imaging session. [18F]FDG–PET scans were performed by a General Electric Discovery LS PET/CT or a multi-ring General Electric Discovery. The [18F]FDG–PET acquisition procedures conformed to the European Association of Nuclear Medicine guidelines (Varrone et al., 2009 (link)). Static emission images were acquired 45 min after injecting 185–250 MBq of [18F]FDG via a venous cannula, with a 15-min scan duration. Data obtained from steady-state static [18F]FDG–PET acquisition were demonstrated to be comparable to the [18F]FDG–PET data obtained from dynamic quantitative acquisition procedures (Signorini et al., 1999 (link)). All images were reconstructed using an ordered subset-expectation maximization algorithm. Attenuation correction was based on CT scans.
Image pre-processing was performed using the SPM12 software running in Matlab (MathWorks Inc., Sherborn, MA, United States). First, each [18F]FDG–PET image was spatially normalized to a specific [18F]FDG–PET template in the MNI space (Della Rosa et al., 2014 (link)). Images were spatially smoothed with an isotropic 3D Gaussian kernel (Full width at half maximum FWHM: 8-8-8 mm). Global mean scaling was applied to each image to account for between-subject uptake variability (Perani et al., 2014 (link)).

Boccalini C., Bortolin E., Carli G., Pilotto A., Galbiati A., Padovani A., Ferini-Strambi L, & Perani D. (2022). Metabolic connectivity of resting-state networks in alpha synucleinopathies, from prodromal to dementia phase. Frontiers in Neuroscience, 16, 930735.

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PET Amyloid Imaging Protocol Qualification

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Site PET scanners were qualified with a Hoffman brain phantom. PET amyloid imaging was performed as part of study AV45-A05.^{25 (link)} Fifty minutes after intravenous injection of 10 mCi (370 MBq) of florbetapir F 18, a 10-min emission scan (acquired in 2 × 5 min frames) was obtained. PET scanners included Discovery LS PET/CT (GE, Fairfield, CT, USA), Advance PET (GE), ECAT HR+ (Siemens, Washington DC, USA) and Biograph PET/CT (Siemens) models. Image reconstruction utilized an iterative algorithm (4 iterations, 16 subsets) and a post reconstruction Gaussian filter of 5 mm.
Three nuclear medicine physicians, blinded to clinical data, independently rated the PET images at an imaging core lab (ICON Medical Imaging, Warrington, PA, USA). A binary qualitative scale (amyloid positive: Aβ+ or amyloid negative: Aβ−) was implemented in this study according to the pattern of tracer uptake observed in cortical gray matter areas. The PET rating methods, visual rater training and reliability have been described previously.^{22 (link),25 (link),27 (link)} In brief, scans were rated as amyloid negative if tracer retention was seen predominantly in white matter, with no appreciable or low levels of tracer retention in cortical gray matter. Scans were rated as amyloid positive when tracer showed a gray matter pattern of distribution with accumulation along the midline and surface of the cortex.

Doraiswamy P.M., Sperling R.A., Johnson K., Reiman E.M., Wong T.Z., Sabbagh M.N., Sadowsky C.H., Fleisher A.S., Carpenter A., Joshi A.D., Lu M., Grundman M., Mintun M.A., Skovronsky D.M, & Pontecorvo M.J. (2014). Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study. Molecular Psychiatry, 19(9), 1044-1051.

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Dynamic PET/CT Imaging Protocol for Rubidium-82 Myocardial Perfusion

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Data acquisitions were performed with a Discovery LS PET/CT (GE HealthCare, Waukesha, WI) in 2-D mode using a multi-frame acquisition protocol over 6 minutes (12 × 8 seconds, 5 × 12 seconds, 1 × 30 seconds, 1 × 60 seconds, 1 × 120 seconds) started immediately after a 30-seconds square-wave infusion of 1450 MBq of [⁸²Rb] rubidium chloride at rest.27 (link) The same acquisition protocol was used for stress imaging starting 2 minutes after the beginning of adenosine infusion. Two low-dose CT scans (120 keV, 10 mAs) were acquired for attenuation correction, one just before the rest study and one immediately after the stress study. CT images were manually reviewed for accurate coregistration with the PET images. Dynamic transverse images were reconstructed using OSEM with a Hann loop filter of 2.34 mm full-width at half maximum (FWHM) and a Hann post-filter of 3.27 mm FWHM. The arterial blood pressure and heart rate, as well as the 12-lead EKG were continuously monitored. The total time in the PET/CT scanner was about 20 minutes and the effective dose due to ⁸²Rb was about 2 mSv for both rest and stress acquisitions, including the CT dose.28 (link)

Dunet V., Klein R., Allenbach G., Renaud J., deKemp R.A, & Prior J.O. (2015). Myocardial blood flow quantification by Rb-82 cardiac PET/CT: A detailed reproducibility study between two semi-automatic analysis programs. Journal of Nuclear Cardiology, 23, 499-510.

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18F-FDG-PET Imaging Protocol for Nuclear Medicine

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All subjects underwent an ¹⁸F-FDG-PET imaging session, using 3D PET scans, either a General Electric Discovery LS PET/CT or a multi-ring General Electric Discovery STE PET/CT at the Department of Nuclear Medicine, San Raffaele Hospital, Milan, Italy. Patients received an intravenous injection of approximately 270 MBq of ¹⁸F-FDG (mean dose 250,60 MBq; SD: 56,41 range 179–351) in rest condition, lying supine in a quiet, dimly-lit room. Image acquisition started approximately 45min after injection, with a scan duration of 15 minutes. In particular, before radiopharmaceutical injection of ¹⁸F-FDG, subjects were fasted for at least 6 hours and measured blood glucose level threshold of <120 mg/dL. Image reconstruction followed an ordered subset expectation maximization (OSEM) algorithm. CT was co-registered and used for attenuation correction. Scatter correction was applied with software integrated in our scanner. The protocol has been approved by the San Raffaele Hospital Local Ethical Committee. All the patients gave informed written consent.

Iaccarino L., Crespi C., Della Rosa P.A., Catricalà E., Guidi L., Marcone A., Tagliavini F., Magnani G., Cappa S.F, & Perani D. (2015). The Semantic Variant of Primary Progressive Aphasia: Clinical and Neuroimaging Evidence in Single Subjects. PLoS ONE, 10(3), e0120197.

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PET/CT Imaging with Microtron Accelerator

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In the present study, 50 MV X-rays were generated using the MM50 Racetrack Microtron accelerator (IBA, Louvain, Belgium). The accelerator has a photon energy range of 10-50 MV. A Discovery LS PET/CT and a Geiger counter (GE, Fairfield, CT, USA) were used to carry out the imaging study. The PET scans were performed in a two-dimensional (2D) fashion. The emission data were reconstructed by means of an iterative reconstruction algorithm using two iterations and eight subsets. The transmission scans for the correction of attenuation were performed with 68-Ge rod sources and reconstructed using filtered back projection. During postprocessing, various corrections were applied, such as for random scatter, attenuation, and dead time.

Tu W.Y., Zhang Z.Y., Jun Z., Xu X.L., Ding J.P., Su J.H, & Chen Z.M. (2018). Positron imaging for verification of irradiation field during radiotherapy. Journal of cancer research and therapeutics, 14(Supplement).

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