Isovue 370

Manufactured by Bracco

Sourced in United States, Italy, Canada, Jersey

Isovue 370 is a non-ionic iodinated contrast medium used for diagnostic imaging procedures. It contains the active ingredient iodixanol, which has an osmolality of 290 mOsm/kg water, making it an isotonic solution. Isovue 370 is indicated for use in various radiographic examinations, such as computed tomography (CT) scans, angiography, and other imaging applications.

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Lab products found in correlation

Aquilion one, by Toshiba (7 mentions) Lightspeed vct, by GE Healthcare (4 mentions) Fmt scanner, by PerkinElmer (4 mentions) Inveon pet ct, by Siemens (4 mentions) Prosense 680, by PerkinElmer (4 mentions) Lightspeed, by GE Healthcare (3 mentions) Discovery ct750 hd, by GE Healthcare (3 mentions) Aquilion one, by Canon (2 mentions) Aquilion, by Toshiba (2 mentions) Visipaque 320, by GE Healthcare (2 mentions) Omnipaque 350, by GE Healthcare (2 mentions) Methocel, by Dow (2 mentions) 40 slice definition, by Siemens (2 mentions) Somatom definition flash, by Siemens (2 mentions) Explore ct 120, by GE Healthcare (1 mentions) Isovue 300, by Bracco (1 mentions) Definition flash, by Siemens (1 mentions) 2767 sample manager, by Waters Corporation (1 mentions) 2525 quaternary pump, by Waters Corporation (1 mentions) 3100 mass detector, by Waters Corporation (1 mentions)

61 protocols using isovue 370

Dye Infusion and Histopathology Protocols

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A mixture of 4% Methylene blue, 76% sterile saline and 20% contrast medium (Isovue 370, Bracco Diagnostic Inc,) was used for the dye infusion group. Infusion volumes were 0.1 ml (n=3), 0.3 ml (n=7), and 1.0 ml (n=3) respectively.
A mixture of 80% sterile normal saline and 20% contrast medium (Isovue 370, Bracco Diagnostic Inc,) was used for the histopathology group. Infusion volumes were 0.3 ml (n=17), 1.0 ml (n=16), and 3.0 ml (n=12) respectively.

Tsukada H., Seward K.P., Rafeq S., Kocher O, & Ernst A. (2015). Experimental Pilot Study of a Novel Endobronchial Drug Delivery Catheter. Journal of bronchology & interventional pulmonology, 22(4), 312-318.

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Abdominal CT Arterial Phase Imaging

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CT data were acquired helically using the central 64 detector rows of a first generation 320 (Aquilion ONE, Toshiba Medical Systems Corporation) or 2×32 (Sensation, Siemens Medical Solutions) detector row scanner. Standard institutional imaging and contrast injection protocols were used for all scans. Either 75 or 100 mL (depending on estimated glomerular filtration rate) iopamidol (370 mgI/ml, Isovue-370, Bracco Diagnostics, Princeton, NJ) was injected at 4 mL/s followed by 40 mL of saline. CT acquisition was timed for the arterial phase by automated bolus tracking in the abdominal aorta using a 180–200 Hounsfield unit (HU) threshold. Other parameters were 120 kVp tube potential, z-axis automatic tube current modulation, and 0.75–1 pitch. Images were reconstructed at 1–3 mm thickness using soft tissue kernels (B30f/FC08).

George E., Giannopoulos A.A., Aghayev A., Rohatgi S., Imanzadeh A., Antoniadis A.P., Kumamaru K.K., Chatzizisis Y.S., Dunne R., Steigner M., Hanley M., Gravereaux E.C., Rybicki F.J, & Mitsouras D. (2015). Contrast Inhomogeneity in CT Angiography of the Abdominal Aortic Aneurysm. Journal of cardiovascular computed tomography, 10(2), 179-183.

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In Vivo Degradation of Metallic Wires

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In vivo degradation of metallic wires was evaluated by high-resolution micro-CT (GE eXplore CT-120) at week 2, 4, 8, 12, and 24 after implantation. Animals were anesthetized with 3% isoflurane in 1L/minute oxygen flow and then CT scanning was performed. For enhanced micro-CT, 1 mL 76% Iopamidol (ISOVUE-370, Bracco Diagnostics, USA) was injected through the rat tail vein prior to scanning. For each metallic wire, 100 scanning planes were obtained and only the middle 50 scanning planes were used to calculate the volume of metallic wire. In vivo degradation of metallic wires was defined as a ratio of metallic wire volume at each time point to metallic wire volume before implantation and expressed as a percentage.

Fu J., Su Y., Qin Y.X., Zheng Y., Wang Y, & Zhu D. (2019). Evolution of metallic cardiovascular stent materials: a comparative study among stainless steel, magnesium and zinc. Biomaterials, 230, 119641.

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Imaging Protocol for Cerebrovascular CTA

Cited 2 times

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Axial NCCT examinations were obtained with 5-mm slice thickness reconstruction. CTA was performed as part of standard clinical care by scanning from the base of the skull base to the vertex using an axial technique, 0.5 section pitch, 1.25-mm collimation, kVp 120 – 140. Prior publications of an overlapping cohort described that CTA scans at our institution were typically acquired at either 235 or 350 mA^{14 (link),15 (link)}. On detailed review we found that a wide range of mA (80 to 630) was used in clinical practice. Intravenous iodinated contrast material (65 to 85 mL), was administered by power injector with an infusion rate of 4-5 mL/s with Smart-Prep, a semiautomatic contrast bolus triggering technique. The contrast materials used were IsoVue 370 and IsoVue 300 (iopamidal, Bracco Diagnostics Inc, Milan, Italy). Volumetric Computed Tomography Dose Index (CTDI-vol) ranged from 34.7 to 89.4 mGy (mean 60.9, SD 16.6) and Dose-Length Product (DLP) ranged from 628.7 to 3763.4 mGy–cm (mean 1923.6, SD 957.5).

Morotti A., Romero J.M., Jessel M.J., Brouwers H.B., Gupta R., Schwab K., Vashkevich A., Ayres A., Anderson C.D., Gurol M.E., Viswanathan A., Greenberg S.M., Rosand J, & Goldstein J.N. (2016). Effect of CTA Tube Current on Spot Sign Detection and Accuracy for Prediction of Intracerebral Hemorrhage Expansion. AJNR: American Journal of Neuroradiology, 37(10), 1781-1786.

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Multimodal Stroke Imaging Protocol

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The study patients underwent an institutional stroke imaging protocol, including noncontrast CT, CT angiogram, and CTP. CT was performed on a 40-mm, 64-detector row clinical system (LightSpeed VCT; GE Healthcare, Milwaukee, WI). Helical noncontrast CT (120 kV; 100-350 auto-mA; CT dose index, ≈43.15) was performed from the foramen magnum through the vertex at a 5.0-mm section thickness. In the absence of visible intracranial hemorrhage during real-time evaluation by vascular neurologist, 2 contiguous CTP slabs were obtained for 8-cm combined coverage of the supratentorial brain, obtained at eight 5-mm sections per slab. Cine mode acquisition (80 kV; 100 mA; CT dose index, ≈293.48) permitting high-temporal resolution (1-s sampling interval) dynamic bolus passage imaging was obtained after the administration of 35-mL iodinated contrast (iopamidol, Isovue 370; Bracco, Princeton, NJ) power injected at 5 mL/s through an 18-ga or larger antecubital intravenous access. Contrast administration was followed by a 25-mL saline flush at the same rate. Finally, helical CT angiogram (120 kV; 200-350 auto-mA; CT dose index, ≈38.08) was performed from the carina to the vertex (section thickness/interval, 0.625/0.375 mm) after intravenous administration of 70-mL iodinated contrast injected at 5 mL/s and followed by a 25-mL saline flush.

Nogueira R.G., Haussen D.C., Dehkharghani S., Rebello L.C., Lima A., Bowen M., Belagaje S., Anderson A, & Frankel M. (2016). Large Volumes of Critically Hypoperfused Penumbral Tissue Do Not Preclude Good Outcomes After Complete Endovascular Reperfusion: Redefining Malignant Profile. Stroke, 47(1).

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Dynamic CT Imaging of Pulmonary Embolism

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Each animal was imaged supine and head-first with a 320-slice CT scanner (Aquilion One, Canon Medical Systems, Tustin, CA, USA), where the caudal lung region was localized within a 16-cm z-axis coverage. After each PE induction, contrast (0.5 mL/kg, Isovue 370, Bracco Diagnostics, Princeton, NJ, USA) and a saline chaser (0.25 mL/kg) were injected at a rate of 5 mL/s (Empower CTA, Acist Medical Systems, Eden Prairie, MN, USA). For each CT measurement, ventilation was paused at end inspiration and 20 ECG-gated dynamic CT volume scans were acquired at 100 kV and 200 mA (320 mm × 0.5 mm detector collimation, 320–400 mm scan field-of-view, 0.35 s rotation time). Full projection CT data were reconstructed at 75% R-R interval using an adaptive iterative dose reduction three-dimensional (3D) algorithm and a standard lung kernel FC07 (512×512 matrix, 0.5-mm slice thickness and slice interval, 320–400 mm reconstruction field-of-view). The image with maximum contrast enhancement was then used as the CTPA image for MCP analysis. Subsequent CT acquisitions were repeated at least 15-minute apart to allow for adequate contrast clearance and recirculation from the previous injection. The CT dose index (CTDI) and the dose-length product (DLP) were also collected from the dose report sheet.

Zhao Y., Malkasian S., Hubbard L, & Molloi S. (2023). Validation of an automated technique for quantification of pulmonary perfusion territories using computed tomography angiography. Quantitative Imaging in Medicine and Surgery, 13(5), 3115-3126.

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Dual-Energy CTA for Vascular Imaging

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Computed tomographic angiography (CTA) was performed prior to the intervention using a dual-energy scanner (256 slices; Siemens Definition Flash, Siemens Healthcare), using a rotation time of 280 ms at a temporal resolution of 75 ms and 0.6-mm collimation. For carotid arteries, Isovue 370 (Bracco Diagnostics; 80 mL at 5.0 mL/s) was injected through a central venous line. Images were acquired from the proximal ascending aorta to the base of the skull (dual-energy mode; 90 kVp and Sn 150 kVp). For the coronary arteries, animals were pretreated with intravenous metoprolol (5 mg every 5 minutes, for a total of 25 mg) and inhalational nitroglycerin (0.8 mg, 2 minutes before acquisition) and thereafter injected with Isovue 370 (77 mL at 5.5 mL/s). Acquisition was performed with high-pitch prospective electrocardiographic gating (FLASH) (tube voltage 70 kV). Important vascular structures (left ventricle, coronary arteries, aorta, and carotid arteries) were segmented and reconstructed in 3 dimensions from computed tomographic slices using EnSite Verismo software (Abbott Medical).

Dorval J.F., Richer L.P., Soucie L., McSpadden L.C., Hoopai A., Tan S., West N.E, & Jolicoeur E.M. (2021). Electroanatomical Navigation to Minimize Contrast Medium or X-Rays During Stenting: Insights From an Experimental Model. JACC: Basic to Translational Science, 7(2), 131-142.

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Cardiac CT Angiography Protocol

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Images were acquired using a 320-detector CT scanner (Aquilion ONE, Toshiba Medical Systems, Otawara, Japan) up to one week before the procedure. Slice thickness was 0.5 mm, and tube voltage was 80, 100, or 120 kV, depending on the body habitus. Tube current ranged from 320 to 580 mA, depending on the body habitus and heart rate. Image acquisition was ECG-gated at 40% R-R interval during a breath-hold. The contrast protocol included a total volume of 60 mL (70 mL if BMI >30 kg/m²) of the nonionic low-osmolar iodinated contrast material iopamidol (Isovue 370, Bracco Diagnostics, Princeton, NJ) administered at a rate of 5 mL/s. First pass images were used for segmentation and analysis.

Ciuffo L., Nguyen H., Marques M.D., Aronis K.N., Sivasambu B., de Vasconcelos H.D., Tao S., Spragg D.D., Marine J.E., Berger R.D., Lima J.A., Calkins H, & Ashikaga H. (2019). Periatrial Fat Quality Predicts Atrial Fibrillation Ablation Outcome. Circulation. Cardiovascular imaging, 12(6), e008764.

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Characterization of Bi-HPDO3A Compound

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All chemicals were purchased from Sigma-Aldrich, all the solvents from VWR, HPDO3A and Iopamidol (Isovue 370) were kindly provided by Bracco Imaging S.p.A.
Electrospray ionization (ESI)-mass spectrometer (ESI-MS) of Bi-HPDO3A was obtained on Waters system (3100 Mass Detector, 2525 quaternary pump, 2767 sample manager, 2996 PDA detector). ¹H-NMR spectra and ¹³C-NMR spectra were measured on a Bruker Avance spectrometer (600 MHz) instrument. Chemical shifts are reported in parts per million (ppm) and are referenced to tetramethylsilane.
UV/Vis spectrophotometric measures were performed on a UV/Vis spectrophotometer (6715, Jenway).

Rizzo R., Capozza M., Carrera C, & Terreno E. (2023). Bi-HPDO3A as a novel contrast agent for X-ray computed tomography. Scientific Reports, 13, 16747.

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Bi-HPDO3A as CT Contrast Agent

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Aqueous solutions at different Bi-HPDO3A concentrations (3–400 mM range) were prepared, and in vitro CT imaging was performed (MiLabs VECTor^{6 (link)}, 65 kV, 0.25 mA, 45 ms). A commercially available solution of iopamidol (Isovue-370^® Bracco Imaging), properly diluted, was used as reference.
For in vivo CT imaging experiments, mice were anaesthetized with isoflurane (1.5–2.5%, 1 mL/min oxygen flow rate) and then scanned before and after the injection via the tail vein of 100 µL of Bi-HPDO3A or iopamidol solutions to reach a dose of 0.5, 1.2 and 5 mmol Bi/kg bw or 1.2 mmol I/kg bw, respectively. CT scans were acquired at different time points (0, 1 min, 5 min, 20 min, 40 min, 1 h). The parameters were set as follows: field of view 54 × 140 mm, tube current 0.25 mA, tube voltage 65 kV, exposure time 45 ms. VOIs analysis for kidneys and bladder were performed to semi-quantify the complex distribution in these main involved organs.

Rizzo R., Capozza M., Carrera C, & Terreno E. (2023). Bi-HPDO3A as a novel contrast agent for X-ray computed tomography. Scientific Reports, 13, 16747.

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