Kaplan-Meier curves and log rank tests of both mortality and hospitalizations were performed after stratifying by analysis subgroups. On multivariate Cox regression analysis, variables were included if they were independently associated with both the outcome and the exposure (p < 0·05) or if they modified the risk ratio estimate for any of the remaining covariates (> 0·5% change). Survival models were always adjusted for age, sex, pack-years, body mass index, Charlson index and current treatment. As an additional analysis, Poisson regression with overdispersion correction by Pearson were used to assess the significance of the weighted rate ratios for hospitalization.
All effects were considered significant with a p value < 0·05. Statistical analyses were performed using the Statistical Package for the Social Sciences, v13.0 (SPSS Inc, Chicago, IL, USA) and SAS for Windows statistical software, v9.2 (SAS Institute, Inc., Carey, NC, USA).