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Z guggulsterone

Manufactured by Santa Cruz Biotechnology
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Sourced in United States

Z-Guggulsterone is a chemical compound derived from the resin of the Commiphora wightii plant. It is a steroid-like molecule that is used in various research applications. The core function of Z-Guggulsterone is to serve as a research tool for studying biological processes and pathways in which it may play a role.

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Lab products found in correlation

Jte 013, by Merck Group (3 mentions) Ca 074 me, by Merck Group (2 mentions) Belnacasan vx 765, by Selleck Chemicals (2 mentions) Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (2 mentions) Rpmi 1640, by Thermo Fisher Scientific (2 mentions) N acetyl l cysteine, by Merck Group (2 mentions) Methoctramine, by Adooq (2 mentions) Dmem f12, by Thermo Fisher Scientific (2 mentions) 2 7 dichlorofluorescein diacetate dcf da, by Thermo Fisher Scientific (2 mentions) Dimethyl sulfoxide (dmso), by Biosharp (1 mentions) 4 6 diamidino 2 phenylindole (dapi), by Santa Cruz Biotechnology (1 mentions) Dnase 1, by Roche (1 mentions) Trypsin, by Solarbio (1 mentions) Dylight 488 conjugated goat anti rabbit igg, by EarthOx (1 mentions) Chenodeoxycholic acid, by Merck Group (1 mentions) Tyrphostin ag 1478, by Merck Group (1 mentions) Sp600125, by Cell Signaling Technology (1 mentions) Cytochalasin d, by Santa Cruz Biotechnology (1 mentions) A438079, by Merck Group (1 mentions) Sq22536, by Abcam (1 mentions)

6 protocols using z guggulsterone

1

Procurement of Bile Acid Compounds

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Z-guggulsterone was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA), Chenodeoxycholic acid (CDCA), deoxycholic acid (DCA), ursodeoxycholic acid (UDCA) were purchased from Shanghai Yiji Co., Ltd (Shanghai, China). Lithocholic acid (LCA) and cholic acid (CA) were purchased from Shanghai Guidechem Co., Ltd (Shanghai, China).
Zhao C., Wang X., Cong Y., Deng Y., Xu Y., Chen A, & Yin Y. (2014). Effects of Bile Acids and the Bile Acid Receptor FXR Agonist on the Respiratory Rhythm in the In Vitro Brainstem Medulla Slice of Neonatal Sprague-Dawley Rats. PLoS ONE, 9(11), e112212.
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2

FXR Activation in Cell Culture

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Trypsin was purchased from Solarbio (Beijing, China), DNase I was purchased from Roche Diagnostics GmbH (Mannheim, Germany), DMEM/F-12 was purchased from Thermo Fisher Scientific Inc. (Waltham, MA, USA), newborn calf serum was purchased from Shanghai ExCell Biology, Inc. (Shanghai, China), dimethyl sulfoxide was purchased from Biosharp (Hefei, China), chenodeoxycholic acid (CDCA) was purchased from Shanghai Yiji Co., Ltd. (Shanghai, China), Z-guggulsterone, rabbit polyclonal anti-FXR antibody, and DAPI were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA), and rat IgG and DyLight® 488-conjugated goat anti-rabbit IgG were purchased from EarthOx, LLC (Millbrae, California, USA).
Wang J., Huang Y., Hou X., Wu W., Nie L., Tian Y., Lu Y, & Yin Y. (2016). Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro. BioMed Research International, 2016, 9283204.
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3

Inflammatory Pathways Modulation Protocol

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Lipopolysaccharide (LPS), Chenodeoxycholic acid (CDCA), CA-074 Me, Tyrphostin AG 1478, A438079 and N-acetyl-L-cysteine (NAC) were purchased from Sigma-Aldrich (St. Louis, MO). SQ22536 was obtained from Abcam (Cambridge, MA). Cytochalasin D and Z-Guggulsterone were purchased from Santa cruz Biotechnology (Santa cruz, CA). VX-765 (belnacasan) and MK-2206 were purchased from Selleck ( Houston, TX). SP600125 and U0126 were obtained from Cell Signaling Technologies (Beverly, MA). RPMI 1640, DMEM and antibiotics were obtained from Invitrogen (Carlsbad, CA). 2’, 7’-dichlorofluorescein diacetate (DCF-DA) were from Invitrogen/Molecular Probes. ELISA Kits were purchased from eBioscience (San Diego, CA).
Gong Z., Zhou J., Zhao S., Tian C., Wang P., Xu C., Chen Y., Cai W, & Wu J. (2016). Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis. Oncotarget, 7(51), 83951-83963.
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4

Molecular Regulators of Lipid Metabolism

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Deoxycholic acid and JTE-013 were obtained from Sigma-Aldrich (St. Louis, MO, USA). Triamterene, 4-DAMP, ketoconazole, lovastatin, KG-501 and fatostatin were purchased from MedChemexpress (Monmouth Junction, NJ, USA). Methoctramine was from AdooQ Bioscience (Nanjing, China). Z-Guggulsterone was from Santa cruz Biotechnology (Santa cruz, CA, USA). SREBP2 antibody was obtained from R&D Systems (Minneapolis, MN, USA).
Li D., Zhou J., Wang L., Gong Z., Le H., Huang Y., Xu C., Tian C., Cai W, & Wu J. (2023). Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation. Cell & Bioscience, 13, 186.
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5

Signaling Pathway Inhibition Protocol

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Deoxycholic acid (DCA) and JTE-013 were purchased from Sigma-Aldrich (St. Louis, MO). Z-Guggulsterone was purchased from Santa cruz Biotechnology (Santa cruz, CA). Phospherylated and total ERK, JNK, IκB antibodies and SP600125, SB 203580, U0126 were purchased from Cell Signaling Technologies (Beverly, MA). Vancomycin, QNZ and SKI-606 were obtained from Selleckchem (Houston, TX). Methoctramine was purchased from AdooQ Bioscience (Irvine, CA). SR 11302 was purchased from APExBIO (Houston, TX). C29 was obtained from MedChemExpress (Monmouth Junction, NJ). TLR2, Src antibodies were from Abcam and phosphotyrosine antibody (4G10) was from Millipore. ELISA Kits were obtained from eBioscience (San Diego, CA).
Wang L., Gong Z., Zhang X., Zhu F., Liu Y., Jin C., Du X., Xu C., Chen Y., Cai W., Tian C, & Wu J. (2020). Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation. Gut Microbes, 12(1), 1819155.
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6

Inflammasome Activation Inhibitor Protocol

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Lipopolysaccharide (LPS), DCA, CA-074 Me, N-acetyl-l-cysteine (NAC), and JTE-013 were purchased from Sigma-Aldrich (St. Louis, MO, USA). Poly (dA:dT) was obtained from Invivogen (San Diego, CA, USA). Nigericin was purchased from Cayman Chemical (Ann Arbor, MI, USA). Z-Guggulsterone was obtained from Santa cruz Biotechnology (Santa Cruz, CA, USA). VX-765 (belnacasan) was purchased from Selleck (Houston, TX, USA). 2′,7′-dichlorofluorescein diacetate (DCF-DA) was from Invitrogen/molecular probes. RPMI 1640, DMEM, and antibiotics were obtained from Invitrogen (Carlsbad, CA, USA). ELISA Kits were purchased from eBioscience (San Diego, CA, USA).
Zhao S., Gong Z., Zhou J., Tian C., Gao Y., Xu C., Chen Y., Cai W, & Wu J. (2016). Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice. Frontiers in Immunology, 7, 536.
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