5 fluorouracil 5 fu

Clopidogrel was isolated from Plavix (Sanofi Aventis) at the Lodz University of Technology, Poland.
Following anticancer drugs were used in this study: cyclophosphamide (CP)—Baxter Oncology GmbH, (Germany); docetaxel (DTX) and mitoxantrone (MTX)—Ak Scientific (USA); 5-fluorouracil (5-FU)—Medac (UK); cisplatin (CDDP)—Teva Pharmaceuticals Poland Sp. z o.o. (Poland); doxorubicin (DOX)—Sigma-Aldrich Chemie GmbH (Germany); tamoxifen (TMX)—Ebewe Pharma (Austria).

The merosesquiterpenes used in this study (Figure 1) were isolated from the sponges Haliclona sp. (smenospongine) [20 (link)] and Verongula rigida (smenospongorine, smenospongiarine, smenospongidine, ilimaquinone, 5-epi-ilimaquinone, quintaquinone, cyclospongiaquinone-1, smenodiol, dactylospontriol, and 3-farnesyl-2-hydroxy-5-methoxy quinone) [21 (link)], as described. All tested compounds were directly used with no additional purification steps. The structures were reauthenticated using spectroscopic analysis, particularly NMR spectroscopy. The spectral data were identical to those reported previously [20 (link),21 (link),22 (link),23 (link),24 (link),25 (link),26 (link),27 (link),28 (link),29 (link)]. The NMR spectrum of each tested compound revealed almost no signals of impurity. The compounds were stored at −20 °C until experiments were carried out. Please see Supporting Information for the isolation and ¹H NMR spectral data (Figures S1–S11). The anticancer drug 5-fluorouracil (5-FU) was from Medac (Wedel, Germany) and provided by the pharmacy of the University Medical Center Mainz.