Diacetyl l tartaric anhydride datan

Manufactured by Merck Group

Diacetyl-L-tartaric anhydride (DATAN) is a chemical compound used in various laboratory applications. It serves as a versatile reagent for chemical synthesis and analysis. DATAN's core function is to facilitate specific chemical transformations and reactions in controlled laboratory environments.

Automatically generated - may contain errors

Lab products found in correlation

Nabh4, by Merck Group (2 mentions) D 2 hg, by Merck Group (2 mentions) Anhydrous meoh, by Merck Group (2 mentions)

Spelling variants of this product

Diacetyl (29 citations) Tartaric (11 citations) DATAN (2 citations)

2 protocols using diacetyl l tartaric anhydride datan

Synthesis of Deuterated 2-Hydroxyglutarate

Check if the same lab product or an alternative is used in the 5 most similar protocols

D2HG and Diacetyl-L-tartaric anhydride (DATAN) were purchased from Sigma/Aldrich. Racemic mixture of L- and D2HG-d4 was prepared by mixing 1 mg of α-ketoglutarate-d6 (Sigma/Isotec) with 1 mg of NaBH₄ (Sigma) in 0.2 mL anhydrous MeOH (Sigma) followed by 30-minute incubation at 60°C. Sodium hydroxide (25%) and formic acid (98%) were from Fluka, Germany (mass spectrometry grade). Other reagents and solvents were of analytical grade.

Waitkus M.S., Pirozzi C.J., Moure C.J., Diplas B.H., Hansen L., Carpenter A., Yang R., Wang Z., Ingram B.O., Karoly E.D., Mohney R.P., Spasojevic I., McLendon R.E., Friedman H.S., He Y., Bigner D.D, & Yan H. (2017). Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1R132H induced metabolic liabilities. Cancer research, 78(1), 36-50.

+ Open protocol

+ Expand

Synthesis of isotopically-labeled 2-HG

Check if the same lab product or an alternative is used in the 5 most similar protocols

D-2-HG and Diacetyl-L-tartaric anhydride (DATAN) were from Sigma/Aldrich. Racemic mixture of L- and D-2-HG-d4 was prepared by mixing 1 mg of α-ketoglutarate-d6 (Sigma/Isotec) with 1 mg of NaBH₄ (Sigma) in 0.2 mL anhydrous MeOH (Sigma) followed by 30 min incubation at 60°C. Sodium hydroxide (25%) and formic acid (98%) were from Fluka, Germany (mass spectrometry grade). Other reagents and solvents were of analytical grade.

Pirozzi C.J., Carpenter A.B., Waitkus M.S., Wang C.Y., Zhu H., Hansen L.J., Chen L.H., Greer P.K., Feng J., Wang Y., Bock C.B., Fan P., Spasojevic I., McLendon R.E., Bigner D.D., He Y, & Yan H. (2017). Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. Molecular cancer research : MCR, 15(5), 507-520.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!