Q2000 dsc

Manufactured by Waters Corporation

Sourced in United States

The Q2000 DSC is a differential scanning calorimeter (DSC) manufactured by Waters Corporation. It is a thermal analysis instrument used to measure the physical and chemical properties of a wide range of materials as they are heated, cooled, or held at a constant temperature. The Q2000 DSC provides precise measurements of heat flow and temperature, allowing users to characterize phase transitions, reaction kinetics, and other thermal events in their samples.

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Lab products found in correlation

Discovery tga, by Waters Corporation (3 mentions) Universal analysis 2000, by TA Instruments (2 mentions) Trios software, by TA Instruments (2 mentions) Ta advantage software for q series, by TA Instruments (1 mentions)

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Q2000 (11 citations)

3 protocols using q2000 dsc

Thermal Characterization of Drug-Loaded Printlets

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Differential scanning calorimetry (DSC) was used to characterise the powders and the drug-loaded printlets at 100 mm/s, 120 mm/s, 140 mm/s,160 mm/s and 180 mm/s laser scanning speeds. DSC measurements were performed with a Q2000 DSC (TA instruments, Waters, LLC, USA) at a heating rate of 10 °C/min starting from 45 to 300 °C. Calibration for cell constant and enthalpy was performed with indium (Tm = 156.6 °C, DHf = 28.71 J/g) according to the manufacturer instructions. Nitrogen was used as a purge gas with a flow rate of 50 mL/min for all the experiments. Data were collected with TA Advantage software for Q series (version 2.8.394), and analysed using TA Instruments.
For thermogravimetric (TGA) analysis, samples (average weight: 3–5 mg) were heated at 10 °C/min starting from 30 to 400 °C in open aluminium pans with a Discovery TGA (TA instruments, Waters, LLC, USA). Nitrogen was used as a purge gas with a flow rate of 25 mL/min. Data were collected and analysed by using TA Instruments Trios software. The results from thermal analysis were plotted using MATLAB software version R2019a (The MathWorks, CA, USA).

Trenfield S.J., Xu X., Goyanes A., Rowland M., Wilsdon D., Gaisford S, & Basit A.W. (2022). Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy. International Journal of Pharmaceutics: X, 5, 100148.

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Thermal analysis of drug-loaded printlets

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Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) wasere used to characterise the powders and the drug loaded printlets. DSC measurements were performed with a Q2000 DSC (TA instruments, Waters, LLC, USA) at a heating rate of 10°C/min. Calibration for cell constant and enthalpy was performed with indium (Tm = 156.6°C, ∆Hf =28.71 J/g) according to the manufacturer instructions. Nitrogen was used as a purge gas with a flow rate of 50 mL/min for all the experiments. Data were collected with TA Advantage software for Q series (version 2.8.394), and analysed using TA Instruments Universal Analysis 2000. All melting temperatures are reported as extrapolated onset unless otherwise stated. TA aluminium pans and lids (Tzero) were used with an average sample mass of 8-10mg.
For TGA analysis, samples were heated at 10°C/min in open aluminium pans with a Discovery TGA (TA instruments, Waters, LLC, USA). Nitrogen was used as a purge gas with a flow rate of 25 mL/min. Data collection and analysis were performed using TA Instruments Trios software and % mass loss and/or onset temperature were calculated.

Fina F., Goyanes A., Gaisford S, & Basit A.W. (2017). Selective laser sintering (SLS) 3D printing of medicines. International journal of pharmaceutics, 529(1-2).

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Thermal Analysis of 3D Printed Caplets

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Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were used to characterise the filaments and single drug loaded 3D printed caplets. DSC measurements were performed with a Q2000 DSC (TA instruments, Waters, LLC, USA) at a heating rate of 10°C/min. Calibration for cell constant and enthalpy was performed with indium (Tm = 156.6°C, ∆Hf =28.71 J/g) according to the manufacturer instructions. Nitrogen was used as a purge gas with a flow rate of 50 mL/min for all the experiments. Data were collected with TA Advantage software for Q series (version 2.8.394), and analysed using TA Instruments Universal Analysis 2000. All melting temperatures are reported as extrapolated onset unless otherwise stated. TA aluminium pans and lids (Tzero) were used with an average sample mass of 8-10mg.
For TGA analysis, samples were heated at 10°C/min in open aluminium pans with a Discovery TGA (TA instruments, Waters, LLC, USA). Nitrogen was used as a purge gas with a flow rate of 25 mL/min. Data collection and analysis were performed using TA Instruments Trios software and % mass loss and/or onset temperature were calculated.

Goyanes A., Wang J., Buanz A., Martínez-Pacheco R., Telford R., Gaisford S, & Basit A.W. (2015). 3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics. Molecular pharmaceutics, 12(11).

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