EDTA plasma collected on day 1, 3 and 5 after inclusion was stored at– 80°C. Copeptin and MR-proADM levels were measured using the commercial sandwich immunoluminometric assays B·R·A·H·M·S™ Copeptin proAVP KRYPTOR™ and B·R·A·H·M·S™ MR-proADM KRYPTOR™ (B·R·A·H·M·S GmbH, part of Thermo Fisher Scientific, Henningsdorf, Germany). The lower limit of quantitation of the assays was 1.23 pmol/L and 0.23 nmol/L, the upper limit of quantitation was 2000 pmol/L and 100 nmol/L for copeptin and MR-proADM, respectively. For MR-proADM, the manufacturer reported for the values between 0.2–0.5 nmol/L and between 0.5–6 nmol/L intra assay precisions of ≤10% and <2–4% and inter assay precisions of ≤18% and <6–11%, respectively. For copeptin, the manufacturer reported for the values between 2–4 pmol/L and between 4–50 pmol/L intra assay precisions of ≤15% and <4–8% and inter assay precisions of ≤18% and <6–10%, respectively. According to maximum inter-assay coefficient of variation (CV%), an increase was set as significant of at least 18% and 20% for copeptin and MR-proADM concentrations, respectively.
Copeptin proavp kryptor
Manufactured by Thermo Fisher Scientific
Sourced in Germany
The Copeptin proAVP KRYPTOR is a laboratory diagnostic test that measures the concentration of copeptin, a surrogate marker for arginine vasopressin (AVP) in human blood samples. The test provides quantitative results and is designed for use with the KRYPTOR analytical platform.
Automatically generated - may contain errors
4 protocols using copeptin proavp kryptor
1
Copeptin and MR-proADM Biomarker Evaluation
2
Serum Copeptin Measurement Assay
3
Serum Copeptin Measurement Assay
4
Lactate and Copeptin Measurement Protocols
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Lactate was measured spectrophotometrically through a lactate oxidase-based method on lithium heparin plasma samples using Siemens ADVIA® 1800 Chemistry System. Internal quality controls were performed on a daily basis and results were considered acceptable when within mean ± 2SD.
Serum samples for copeptin were centrifuged and stored at − 20 °C for batch analysis with a commercial immunofluorescence sandwich immunoassay (B.R.A.H.M.S. Copeptin proAVP KRYPTOR, Thermo Scientific). Assay characteristics declared by manufacturer included a 0.7 pmol/L lower detection limit, < 1.08 pmol/L functional sensitivity and < 8% intra-assay (<10% inter-assay) coefficient of variations for concentrations > 4.0 pmol/L.
Serum samples for copeptin were centrifuged and stored at − 20 °C for batch analysis with a commercial immunofluorescence sandwich immunoassay (B.R.A.H.M.S. Copeptin proAVP KRYPTOR, Thermo Scientific). Assay characteristics declared by manufacturer included a 0.7 pmol/L lower detection limit, < 1.08 pmol/L functional sensitivity and < 8% intra-assay (<10% inter-assay) coefficient of variations for concentrations > 4.0 pmol/L.
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