Signa hdx scanner

Manufactured by GE Healthcare

Sourced in United States, Canada

The Signa HDx scanner is a magnetic resonance imaging (MRI) system designed by GE Healthcare. It provides high-resolution imaging capabilities to support clinical diagnosis and research applications.

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37 protocols using signa hdx scanner

Imaging Brain Resections in Epilepsy

Cited 3 times

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Pre- and postoperative MRI scans were acquired for each subject with refractory epilepsy and were used to delineate their resections. In short, MRI scans were acquired using a 3 T GE Signa HDx scanner using standard imaging gradients, a maximum strength of 40 mT

m^{- 1}

and slew rate of 150 T

m^{- 1} s^{- 1}

. Data were acquired using a body coil for transmission and an eight-channel phased array coil for reception. Standard clinical sequences were performed including a coronal T₁-weighted volumetric acquisition with 170 contiguous 1.1-mm-thick slices (matrix, 256 × 256; in-plane resolution, 0.9375 × 0.9375 mm). Individual MRI scans were preprocessed using FreeSurfer’s pipeline ‘recon-all’^{27 (link)} and subsequently parcellated into 114 neocortical regions of interest (ROI) based on the Lausanne parcellation scheme.^{28 (link)} To delineate the resection cavity, pre- and postoperative MRI scans were linearly coregistered using FSL and overlaid.^{29-31 (link)} Resection volumes were manually drawn for each individual using FSLview, and pre- and postoperative volumes were estimated using custom MATLAB code.^{32 (link)} A region was defined as resected if the pre- and postoperative volume change exceeded 10%.^{20 (link)} Healthy individuals at Cardiff also underwent T₁-weighed MRI acquisition using a 3 T GE Signa HDx scanner. A full description of the acquisition protocol has been described previously.²⁶

Owen T.W., Janiukstyte V., Hall G.R., Chowdhury F.A., Diehl B., McEvoy A., Miserocchi A., de Tisi J., Duncan J.S., Rugg-Gunn F., Wang Y, & Taylor P.N. (2023). Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome. Brain Communications, 5(6), fcad292.

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Automated Parcellation and Resection Analysis

Cited 4 times

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T1‐weighted MRI was performed using a 3T GE Signa HDx scanner. Acquisition details for patients have been reported previously
²³ (link) (acquired in London), and for healthy controls
²⁴ (link) (acquired in Cardiff). We include a copy of the acquisition details in the Supplementary Materials, S1.1. Subject MRI scans were pre‐processed using the FreeSurfer pipeline “recon‐all.”
²⁵ (link) MRI scans were parcellated into cortical regions of interest (ROIs) based on the Lausanne parcellation for four different resolutions (68, 114, 219, and 448 neocortical ROIs).
²⁶ (link) To identify patient‐specific resection cavities, pre‐ and postoperative MRI scans were linearly co‐registered using the FSL tool “FLIRT.”
²⁷ (link),
²⁸ (link),
²⁹ (link) Using FSLview, pre‐ and postoperative MRI were overlaid, with resection volumes manually drawn. Following this, pre‐ and postoperative ROI volumes were calculated using custom MATLAB code.
²³ (link) Regions were categorized as resected if the pre‐ and postsurgical volume change exceeded 10%. Regions with volume changes between 1% and 10% were categorized as “Unknown” and were subsequently removed from any analysis.

Owen T.W., Schroeder G.M., Janiukstyte V., Hall G.R., McEvoy A., Miserocchi A., de Tisi J., Duncan J.S., Rugg‐Gunn F., Wang Y, & Taylor P.N. (2023). MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy. Epilepsia, 64(3), 692-704.

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fMRI Acquisition Protocol for 3T Imaging

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fMRI data was acquired using an 8-channel head coil in a 3T GE Signa HDx scanner and echo planar imaging sequence (TR=2.5s). Details of protocol can be found in Supplemental Methods.

Cai W., Griffiths K., Korgaonkar M.S., Williams L.M, & Menon V. (2019). Inhibition-related modulation of salience and fronto-parietal networks predicts cognitive control ability and inattention symptoms in children with ADHD. Molecular psychiatry, 26(8), 4016-4025.

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High-resolution MRI Protocol for Brain Imaging

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For all subjects, pre-surgical high resolution, T1 fast spoiled gradient-echo (FSPGR) anatomical and diffusion-weighted whole-head MR images were acquired on a 3 Tesla GE Signa HDx scanner with an 8 channel head coil. The FSPGR MR image acquisition parameters were: voxel size = 0.94 mm × 0.94 mm × 1 mm, 256 × 256 matrix, TE = 5.1 ms, TR = 12.0 ms, flip angle = 20°, field of view = 24 cm (controls) and 22 cm (patients). The diffusion-weighted MR image acquisition parameters were: 60 directions, 1 B₀, b = 1000 s/mm², spin echo EPI sequence, 1 excitation, ASSET, voxel size = 0.94 mm × 0.94 mm × 3 mm, 128 × 128 matrix, TE = 86.4 ms, TR = 17 s (controls) and 12 s (patients), flip angle = 90°, field of view = 24 cm.

Hung P.S., Chen D.Q., Davis K.D., Zhong J, & Hodaie M. (2017). Predicting pain relief: Use of pre-surgical trigeminal nerve diffusion metrics in trigeminal neuralgia. NeuroImage : Clinical, 15, 710-718.

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Functional MRI Study of Resting-State Brain

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Neuroimaging data were collected at the First Affiliated Hospital of the College of Medical Science, Zhejiang University using a 3.0-T GE Signa HDx scanner (GE Healthcare, Hangzhou, China) equipped with an eight-channel head coil. The patients were asked to keep their eyes closed and be awake, not to think of anything particular. Sponge pads were placed on both sides of the lower jaw to limit head motion. Conventional axial T2WI MRI was first scanned to exclude white matter lesions, cortical ischemia, or other lesions. Then configuration data were collected through a 3D fast field echo T1-weighted sequence (axial, TR/TE = 8.2/3.2 ms, TI = 100 ms, flip angle = 12°, FOV = 240 mm × 240 mm, matrix = 256 × 256, slice thickness = 1 mm, no gap, in-plane voxel size 1 mm × 1 mm). Finally, the rsfMRI scans were performed using a GRE-EPI sequence: TR/TE = 2,000/40 ms, flip angle 90°, FOV = 24 cm × 24 cm, matrix = 64 × 64, slice thickness = 5 mm, and 1 mm interslice. Each volume comprised of 22 axial slices, and 200 time points were collected, lasted for 6 min and 40 s. The scan orientation was parallel to the anterior and posterior commissure and anterior skull base.

Yang H., Wang C., Zhang Y., Xia L., Feng Z., Li D., Xu S., Xie H., Chen F., Shi Y, & Wang J. (2017). Disrupted Causal Connectivity Anchored in the Posterior Cingulate Cortex in Amnestic Mild Cognitive Impairment. Frontiers in Neurology, 8, 10.

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MRI Acquisition Protocol for Brain Imaging

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MRI data for the development cohort were collected between September 2005 and August 2012 on a 3T Signa HDx Scanner (GE, Milwaukee, WI) at the Epilepsy Society. A coronal T1‐weighted 3‐dimensional (3D) fast spoiled gradient echo with repetition time (TR)/echo time (TE)/inversion time (TI) = 6.6/2.8/450 milliseconds, matrix = 256 × 256 × 178, field of view (FOV) = 24 × 240 × 196mm, voxel size = 0.9375 × 0.9375 × 1.1mm was acquired in all subjects.
In the validation cohort, subjects underwent imaging on a 3T GE Discovery MR750. A 3D T1‐weighted inversion‐recovery fast spoiled gradient recalled echo (TE/TR/TI = 3.1/7.4/400 milliseconds, FOV = 224 × 256 × 256mm, matrix 224 × 256 × 256, parallel imaging acceleration = 2) was acquired in all validation subjects.

Postma T.S., Cury C., Baxendale S., Thompson P.J., Cano‐López I., de Tisi J., Burdett J.L., Sidhu M.K., Caciagli L., Winston G.P., Vos S.B., Thom M., Duncan J.S., Koepp M.J, & Galovic M. (2020). Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy. Annals of Neurology, 88(1), 170-182.

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Multimodal MRI Protocol for Neurological Disorders

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All subjects were scanned on a 3 Tesla GE Signa HDx scanner (GE Medical Systems, Milwaukee, WI, USA). The MRI protocol included 3 D T1-weighted imaging, T2-weighted imaging with a fluid-attenuated inversion recovery (FLAIR) sequence, diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging. Results of the diffusion-weighted imaging analyses are described in (Dalby et al., 2010b (link)). Perfusion imaging was performed with gradient echo (GRE) and spin echo (SE) echo-planar imaging sequences during a bolus injection of 0.1 and 0.2 mmol/kg contrast media (Gadovist^® 1.0 M; Bayer AG, Berlin, Germany) for the GRE and SE echo-planar imaging sequences, respectively. Image acquisition parameters for both sequences comprised slice thickness 5 mm, gap 1.5 mm, 1.88 mm in-plane resolution and TR 1500 ms, while TE was 30 s for GRE and 60 s for SE. The flip angle for GRE was 60°. The contrast bolus was injected after 15 repetitions and immediately followed by injection of 30 ml of physiological saline at a rate of 5 ml/s. A total of 50 repetitions were performed. Bolus injection was delivered in the right antecubital vein for all subjects, except for one patient and two controls where difficult intravenous access required insertion into the left antecubital vein. Total MRI protocol acquisition time was ∼50 min.

Dalby R.B., Eskildsen S.F., Videbech P., Frandsen J., Mouridsen K., Sørensen L., Jeppesen P., Bek T., Rosenberg R, & Østergaard L. (2019). Oxygenation differs among white matter hyperintensities, intersected fiber tracts and unaffected white matter. Brain Communications, 1(1), fcz033.

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Epilepsy MRI Acquisition Protocols

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Participants from UCL were scanned between January 2004 and March 2018. For those scanned between January 2004 and March 2013 (all people with IGE, 336 people with focal epilepsy and 50 control subjects) (Supplementary material, ‘Methods’ section), MRI data were acquired on a 3 T GE Signa HDx scanner with a coronal T₁-weighted 3D inversion recovery fast spoiled gradient echo (IR-FSPGR) sequence, repetition time/echo time/inversion time: 8.1/3.1/450 ms, voxel size: 0.9 × 0.9 × 1.1 mm. For those scanned between March 2013 and March 2018 (355 people with focal epilepsy and 71 healthy control subjects) (Supplementary material, ‘Methods’ section), MRI data were acquired on a 3 T GE Discovery MR750 scanner using a 3D T₁-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence with echo time/repetition time/inversion time: 3.1/7.4/400 ms, voxel size: 1.0 × 1.0 × 1.0 mm. For participants in the external validation cohort, MRI data were acquired at the West China Hospital between June 2013 and December 2020, using a 3 T Siemens Tim Trio MRI scanner with an eight-channel head coil. High-resolution T₁-weighted MRI was acquired using a 3D MPRAGE sequence with repetition time/echo time/inversion time: 1900/2.6/900 ms, voxel size: 1.0 × 1.0 × 1.0 mm.

Xiao F., Caciagli L., Wandschneider B., Sone D., Young A.L., Vos S.B., Winston G.P., Zhang Y., Liu W., An D., Kanber B., Zhou D., Sander J.W., Thom M., Duncan J.S., Alexander D.C., Galovic M, & Koepp M.J. (2023). Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference. Brain, 146(11), 4702-4716.

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Brain Imaging with 3T Gradient Echo EPI

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One hundred eighty‐four gradient echo planar imaging (EPI) volumes were acquired on a 3‐Tesla Signa HDx scanner (GE Healthcare, Little Chalfont, Buckinghamshire, United Kingdom) at the Centre for Neuroimaging Sciences (Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom) with the following parameters: TE = 25 ms, TR = 2,000 ms; flip angle = 75°; slice thickness = 2.4 mm, slice gap = 1 mm, spatial (axial) positions = 38 (prescribed parallel to the AC‐PC line), matrix = 64 × 64, field of view 24.0 cm.

McGinnity C.J., Smith A.B., Yaakub S.N., Weidenbach Gerbase S., Gammerman A., Tyson A.L., Bell T.K., Elmasri M., Barker G.J., Richardson M.P, & Pal D.K. (2017). Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes. Epilepsia Open, 2(2), 214-225.

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fMRI BOLD Response Acquisition Protocol

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Participants underwent fMRI at 1.5 Tesla on a SIGNA HDx scanner (General Electric, Milwaukee, Wisc., USA) equipped with an 8-channel headcoil for radiofrequency transmission and reception. T2*-weighted echo planar images of the whole head depicting the blood oxygen level dependent (BOLD) response were acquired yielding 720 volumes aligned parallel to the intercommissural plane (AC-PC line), each with 27 slices of 5 mm thickness and 0.5 mm gap. fMRI parameters were: repetition time (TR) = 3000 ms, echo-time (TE) = 40 ms, flip angle (FA) = 90°, field of view = 24 cm, NEX = 1. The duration of the actual experiment, which was carried out in one run, was 36 minutes. Following the functional series a high-resolution T1-weighted anatomical axial gradient-spoiled, gradient recalled (SPGR) scan with an inversion time (TI) of 300 ms was acquired. The sequence was acquired with an isotropic resolution of 1.1×1.1×1.1 mm³, FA = 18°, TR = 4.84 ms and TE = 4.84 ms.

Hamm J.P., Crawford T.J., Nebl H., Kean M., Williams S.C, & Ettinger U. (2014). Neural Correlates of Illusory Line Motion. PLoS ONE, 9(1), e87595.

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