Osirix v 8

Manufactured by Pixmeo

Sourced in Switzerland

OsiriX v.8.0.2 is a medical imaging software application for macOS. It is designed to handle and process DICOM images, the standard format for medical imaging. The software provides tools for visualization, analysis, and processing of digital medical images, including CT, MRI, and PET scans.

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Lab products found in correlation

Syngo neuro perfusion ct, by Siemens (1 mentions) Somatom definition force, by Siemens (1 mentions)

Spelling variants of this product

OsiriX (197 citations) OsiriX v. 5.8.5 64-bit (3 citations)

4 protocols using osirix v 8

Multimodal Neuroimaging Protocol for Acute Stroke

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Noncontrast CT, CTA and CTP were performed using SOMATOM Definition Force, AS+ and Flash scanners (Siemens Healthineers, Forchheim, Germany). The CTP data were processed using the manufacturer’s software (syngo Neuro Perfusion CT, Siemens Healthineers) to generate perfusion maps.
For CTA intravenous administration of 50 mL iodinated contrast medium was followed by a saline chaser of 40 mL, each with a flow rate of 5 mL/s. Imaging was performed in a single sweep from the aortic arch to the vertex with a bolus trigger of 100 HU in the aortic trunk. Tube voltage was 120 kV (SOMATOM Force, Flash) or 80 kV (SOMATOM AS+) and tube current modulation (CareDose) was used. Collimation was 0.6 mm.
The ASPECTS was determined by two blinded readers as described in previous studies [13 (link)]. Manual segmentation of total ischemic volume on cerebral blood flow (CBF) maps, ischemic core volume on cerebral blood volume (CBV) maps and final infarction on follow-up CT or MRI were performed using commercial software (OsiriX v. 8.0.2, Pixmeo, Bernex, Switzerland 2017). Final infarction was determined on follow-up imaging at CT or MRI.

Reidler P., Stueckelschweiger L., Puhr-Westerheide D., Feil K., Kellert L., Dimitriadis K., Tiedt S., Herzberg M., Rémi J., Liebig T., Fabritius M.P, & Kunz W.G. (2020). Performance of Automated Attenuation Measurements at Identifying Large Vessel Occlusion Stroke on CT Angiography. Clinical Neuroradiology, 31(3), 763-772.

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Acute Ischemic Stroke Imaging Assessment

Cited 1 time

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Two blinded readers (radiology resident with 3 years [P.R.] and radiology attending with 6 years [W.G.K.] of experience in acute stroke imaging) determined overall ASPECTS on CTASI and ischemic involvement in ASPECTS regions on cerebral blood flow (CBF) maps in separate sessions for each modality. Regional ischemic core as deficit on cerebral blood volume (CBV) maps was determined by two blinded readers as described before [13 (link)]. In case of disagreement, consensus was reached in a separate session. Manual segmentation of total ischemic volume on CBF maps, ischemic core volume on CBV maps and final infarction on follow-up CT or MRI were performed using commercial software (OsiriX v.8.0.2, Pixmeo 2017). Final infarction was determined on follow-up imaging after 24-48h at CT or MRI for all ASPECTS regions and defined as present if ≥20% of the respective region was affected, according to other studies [14 ]. Collateral status was assessed on the scales by Tan et al. and Maas et al. in consensus by experienced readers ([W.G.K], [P.R.]) [10 (link), 15 (link)].

Reidler P., Puhr-Westerheide D., Rotkopf L., Fabritius M.P., Feil K., Kellert L., Tiedt S., Rémi J., Liebig T, & Kunz W.G. (2020). Cerebral attenuation on single-phase CT angiography source images: Automated ischemia detection and morphologic outcome prediction after thrombectomy in patients with ischemic stroke. PLoS ONE, 15(8), e0236956.

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Multimodal CT Imaging for Acute Stroke

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All patients underwent a standardized multiparametric CT protocol consisting of NCCT, CTA, and WB‐CTP with a coverage of 10 cm in the z‐axis. The acquisition protocol has been described in detail before.18 NCCT follow‐up within 72 hours was available in 70%, and magnetic resonance imaging follow‐up in 73% of all patients. Both modalities were available in 43% of all patients. The assessment of all qualitative and quantitative imaging parameters was performed by 2 independent readers who were blinded to all clinical and follow‐up imaging data. In case of disagreement, a consensus was reached in a separate session.
Early ischemic changes were assessed using the 11‐point posterior circulation Acute Stroke Prognosis Early CT Score (pc‐ASPECTS)19 on NCCT, CTA source images, and on parametric WB‐CTP maps of CBF, cerebellar blood volume, mean transit time, time to drain, and time to maximum of the residue function. Vessel occlusions were documented. Cerebellar perfusion deficits on all CTP maps and follow‐up infarction were volumetrically assessed using OsiriX v.8.0.2 (Pixmeo; Bernex, Switzerland) as previously described.18, 20 On magnetic resonance imaging, follow‐up diffusion‐weighted imaging was used. Relative infarction growth was computed as final infarction volume (FIV) divided by CBF deficit volume (FIV/CBF).

Fabritius M.P., Reidler P., Froelich M.F., Rotkopf L.T., Liebig T., Kellert L., Feil K., Tiedt S., Kazmierczak P.M., Thierfelder K.M., Puhr‐Westerheide D, & Kunz W.G. (2019). Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 8(21), e013069.

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Quantifying Ischemic Stroke Severity

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Regional distribution of acute ischemia was determined according to the Alberta Stroke Program Early CT Score (ASPECTS) on CTP cerebral blood flow (CBF) maps as described before by two blinded readers (Reidler et al., 2019 (link)). A region was rated positive if ≥ 20% of the regional volume was affected, in accordance with other studies (d'Esterre et al., 2017 (link)). Further, we analyzed CTA data for the presence of a persisting fetal posterior cerebral artery (PCA) as a possible variant of thalamic blood supply (Dimmick and Faulder, 2009 (link)). Initial total ischemic volume, ischemic core volume and final infarction volume were manually segmented on CBF maps, cerebral blood volume (CBV) maps, and follow-up noncontrast CT or MRI, respectively, using commercial software (OsiriX v.8.0.2, Pixmeo 2017).

Reidler P., Mueller F., Stueckelschweiger L., Feil K., Kellert L., Fabritius M.P., Liebig T., Tiedt S., Puhr-Westerheide D, & Kunz W.G. (2020). Diaschisis revisited: quantitative evaluation of thalamic hypoperfusion in anterior circulation stroke. NeuroImage : Clinical, 27, 102329.

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