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Discovery vct pet ct system

Manufactured by GE Healthcare
Sourced in United States

The Discovery VCT PET/CT system is a diagnostic imaging device that combines positron emission tomography (PET) and computed tomography (CT) technology. It is designed to capture detailed images of the body's structure and function, providing information that can assist healthcare professionals in medical diagnosis and treatment planning.

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7 protocols using discovery vct pet ct system

1

FDG-PET/CT Imaging Protocol for Metabolic Evaluation

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Patients were injected with a standardized dose of 3.5 MBq of 18-fluorodeoxyglucose (FDG) per kilogram body weight after fasting for at least four hours. All patients had a blood glucose level below 12 mmol/l before imaging. The patients were instructed to remain in lying or recumbent position and silent for 50–60 minutes to minimize muscular FDG uptake in the period between FDG injection and image acquisition. Patients were also kept warm prior to tracer injection and throughout the uptake period to diminish FDG accumulation in brown adipose tissue. All patients received either iodinated or gadolinium-based contrast medium. An integrated Discovery VCT PET/CT system (GE Healthcare, Waukesha, WI), a Discovery PET/CT 690 (GE Healthcare), or a hybrid PET/MRI system (Signa PET/MR, GE Healthcare) was used for image acquisition.
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2

PET Imaging of Cerebral Blood Flow During Nitric Oxide-Induced Headache

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All patients had been pain free at least 72 hours before the PET scans. The procedure for GTN infusion and recording of symptoms was repeated as on the first occasion. We performed PET scans with the GE Discovery VCT PET/CT system (Waukesha, WI, United States) in three-dimensional mode with septa retracted. All subjects were instructed to keep their eyes closed during the scans. The subjects were positioned in the PET scanner, and their head immobilized with standard immobilization straps and a low dose CT scan was performed for attenuation correction. CT scans for attenuation correction were repeated when patients exited the scanner for relaxation between conditions. An antecubital vein cannula was used to administer the tracer, 370 MBq of H215O, which was repeated before each scan. The activity was infused into subjects over twenty seconds at a rate of 10 ml/min. The interval between scans was at least ten minutes allowing an interval of five half-lives of H215O (t1/2 = 122 seconds). The PET data were acquired dynamically and summed for one 90-second frame beginning five seconds before the peak of the head curve.
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3

Quantitative 124I-MIBG Imaging for 131I-MIBG Therapy

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All patients received 124I-MIBG administration (1.06 MBq/kg) within 9 days before initiation of 131I-MIBG therapy. Three patients were scanned four times: on the day of (day 0 or time point 1), 1 day (day 1 or time point 2), 2 days (day 2 or time point 3), and 5 days (day 5 or time point 4) after 124I-MIBG administration. Two patients were scanned three times, missing one of the time points. Day 0 scan was performed at 2.23±0.99 hrs postinjection, day 1 scan was performed at 25.14±3.22 hrs postinjection, day 2 scan was performed at 48.47±4.16 hrs postinjection, and day 5 scan was performed at 120.11±4.14 hrs postinjection. Four patient scans were performed on a Discovery VCT PET/CT system (GE Healthcare, Waukesha, WI) at the China Basin Imaging Center of University of California, San Francisco (UCSF) and one patient scan was performed on a Gemini TF PET/CT system (Philips Healthcare, Highland Heights, OH) at the UCSF Benioff Children’s Hospital at Mission Bay. Because of the low activity injected and low positron emission branching ratio of 124I-MIBG, data were acquired for at least 4 minutes per bed.
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4

Multimodal Cardiac Imaging Protocol

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Transthoracic echocardiography was performed using a GE Vivid 7 or E-9 ultrasound machine and a multifrequency phased-array transducer. Left atrial diameter (anteroposterior) was measured in the parasternal long-axis view at the level of the aortic sinuses, perpendicular to the aortic root long axis, by using the leading-edge to leading-edge convention, just before mitral valve opening (LV end-systole).14 (link) Echocardiographic images for 2-dimensional speckle tracking strain analysis were acquired prospectively at frame rates of 50-90 Hz. Longitudinal strain/strain rate was analyzed from the apical 2-, 3-, and 4-chamber views using EchoPAC 112.15 (link) CMR imaging was performed at the first clinic visit, using a 1.5T system, with administration of the contrast agent gadopentetate dimeglumine (0.2 mmol/kg).16 (link) LV mass and late gadolinium enhancement (LV-LGE) were quantified using QMass software (QMass 7.4; Medis, Leiden, The Netherlands). Cardiac 13NH3-PET/CT imaging was performed using a GE Discovery VCT PET/CT system and a 1-day rest/stress protocol, as described previously.17 (link) Please refer to the Supplemental Appendix S1, Section A1 for detailed methods for rest/stress echocardiography, CMR, and PET/CT imaging.
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5

PET/CT Imaging of FDG Uptake

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Patients were injected with a standardized dose of 3.5 MBq of 18-fluorodeoxyglucose (FDG) per kilogram body weight after fasting for at least four hours. All patients had a blood glucose level below 12 mmol/L before imaging. Patients were instructed to remain in a lying or recumbent position and silent for 50–60 min to minimize muscular FDG uptake in the period between FDG injection and image acquisition. Patients were also kept warm prior to tracer injection and throughout the uptake period to diminish FDG accumulation in brown adipose tissue. All patients received either iodinated or gadolinium-based contrast medium. An integrated Discovery VCT PET/CT system (GE Healthcare, Waukesha, WI, USA), a Discovery PET/CT 690 (GE Healthcare), or a hybrid PET/MRI system (Signa PET/MR, GE Healthcare) was used for image acquisition.
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6

PET Brain Imaging with 18F-FDG

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The two subjects fasted for at least 5 h before the i.v. of 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) infusion. Serum glucose level was a minimum of 95 mg/ml, in both of them. They were administered i.v. infusions of 210 MBq of 18F-FDG, were hydrated with 500 ml of NaCl 0.9% and rested 20 min in a dark silent room before undergoing PET examination.
The Discovery VCT PET/CT system (GE Medical Systems, Tennessee, USA) was used to assess FDG brain distribution in all subjects by means of a 3D-mode standard technique in a 256 × 256 matrix. Reconstruction was performed using the 3-dimensional reconstruction method of ordered-subset expectation maximization (OSEM) with 20 subsets and four iterations. The system combines a high-speed ultra 16-detector-row (912 detectors per row), a CT unit and a PET scanner with 10,080 bismuth germanate crystals in 24 rings (axial full width at half-maximum 1-cm radius, 5.2 mm in 3D mode, 157 mm axial field of view). A low-amperage CT scan of the head for attenuation correction (40 mA; 120 Kv) was performed before PET image acquisition.
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7

FDG PET/CT Brain Imaging Protocol

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The Discovery VCT PET/CT system (GE Medical Systems, Tennessee, USA) was used to assess FDG brain distribution in all subjects by means of a 3D-mode standard technique in a 256 Â 256 matrix. Reconstruction was performed using the 3-dimensional reconstruction method of ordered-subset expectation maximization (OSEM) with 20 subsets and four iterations. The system combines a high-speed ultra 16-detector-row (912 detectors per row), a CT unit and a PET scanner with 10080 bismuth germanate crystals in 24 rings (axial full width at half-maximum 1-cm radius, 5.2 mm in 3D mode, 157 mm axial field of view). A low-amperage CT scan of the head for attenuation correction (40 mA; 120 Kv) was performed before PET image acquisition. All subjects fasted for at least 5 h before the i.v. FDG infusion; the serum glucose level was a minimum of 95 mg/ml in all of them. External acoustic stimulation was eliminated by plugging both ears hermetically. All subjects were administered i.v. infusions of 185e210 MBq of FDG and were hydrated with 500 ml of NaCl 0.9%. (Alessandrini et al., 2013; Chiaravalloti et al., 2013; Schecklmann et al., 2013; Alessandrini et al., 2014a; Alessandrini et al., 2014b Alessandrini et al., , 2016;; Chiaravalloti et al., 2015) .
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