Oxethazaine

The FDA Pharmakon compound library was purchased from MicroSource Discovery Systems, Inc. (USA). Compounds were delivered in microplates (10 mM, dissolved in DMSO) and kept at -80°C until use. For in vivo studies, flunarizine hydrochloride, pimozide, nicardipine hydrochloride, oxethazaine, menadione, clofazimine, doramectin and metitepine mesylate were purchased from Sigma-Aldrich (Buchs, Switzerland) and fendiline hydrochloride, manidipine hydrochloride and lomerizine hydrochloride were purchased from Santa-Cruz Biotechnology (California, USA). Hanks Balanced Salt Solution (HBSS) was obtained from Gibco (Lucerne, Switzerland). Culture medium components for NTS and adult worms were obtained as follows: Medium 199 RPMI 1640 and penicillin (100 U/ml) and streptomycin (100 μg/ml) were purchased from Lubioscience (Lucerne, Switzerland) whereas inactivated fetal calf serum (iFCS) was purchased from Connectorate AG (Dietikon, Switzerland).

Individual chemicals, i.e., albendazole, alexidine, azelastine, bosutinib, carmofur, cladribine, digoxigenin, dronedarone, emetine, miconazole, pentamidine, pitavastatin, sertraline, solifenacin, sulcanozole, tadalafil, terfenadine, thioridazine, trifluorothymidine, and toremifene were purchased from Cayman Chemical Company (Ann Arbor, MI, USA). Additionally, 10-deacetylbaccatin, allyl-thiourea, aminoacridine, bazedoxifene, cephalomannine, cetrimonium bromide, ciclopirox, clomifene, cytarabine, fenbendazole, ouabain, oxethazaine, penfluridol, pyrithione zinc, tioconazole, thioguanine, and vinorelbine were purchased from Sigma-Aldrich. Flubendazole was purchased from LKT Laboratories, Inc. (St. Paul, MN, USA), and gemcitabine and niclosamide were purchased from AdipoGen^® Life Science (Liestal, Switzerland), whereas thonzonium bromide and pralatrexate were purchased from MedChemExpress (Monmouth Junction, NJ, USA).