Hirez biograph 16

Manufactured by Siemens

Sourced in United States

The Hirez-Biograph 16 is a medical imaging device used for computed tomography (CT) scanning. It is designed to capture high-resolution, three-dimensional images of the body's internal structures. The device utilizes advanced X-ray technology and sophisticated image processing algorithms to produce detailed visualizations that support medical diagnosis and treatment planning.

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Lab products found in correlation

Biograph mct flow, by Siemens (1 mentions) Syngo via software, by Siemens (1 mentions) Biograph mmr, by Siemens (1 mentions) Biograph mct, by Siemens (1 mentions) Syngo workstation, by Siemens (1 mentions) Tim trio mr, by Siemens (1 mentions) Skyra 3 tesla scanner, by Siemens (1 mentions) Biograph 64, by Siemens (1 mentions) Discovery vct pet ct scanner, by GE Healthcare (1 mentions) Signa pet mr, by GE Healthcare (1 mentions)

9 protocols using hirez biograph 16

Multimodal PET/CT Imaging in Cancer

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[18F]F-Fluorocholine and [68Ga]Ga-PSMA-11 PET/CT were performed according to current guidelines [15 (link),16 ].
Integrated PET/CT scanners using either Hirez-Biograph 16 (Siemens Medical Solutions, Munich, Germany) or Biograph mCT Flow (Siemens Medical Solutions, Munich, Germany) were used to perform a whole-body (skull vertex to the upper thighs) PET acquisition in the three-dimensional mode (emission time: 2 min per bed position with an axial field-of-view of 15.6 cm). A low-dose CT was performed for attenuation correction and anatomical allocation. No diagnostic contrast-enhanced CT scans were performed. Reconstruction was performed with an ordered subset expectation maximization algorithm with four iterations per eight subsets. Images were corrected for random coincidences and scatter.
Images were analyzed using Syngo.via software (Siemens Medical Solutions, Munich, Germany) by two experienced nuclear medicine physicians in consensus. For each lesion identified on transaxial images, a volume of interest (VOI) was drawn with an isocounter threshold based on 40% of the SUVmax. Maximum standardized uptake values (SUVmax), metabolic tumor volume (MTV, calculated as the sum of all lesions), and total lesion glycolysis (TLG, calculated as the sum of the products between MTV and the corresponding SUVmean) were collected.

Lanfranchi F., Belgioia L., Marcenaro M., Zanardi E., Timon G., Riondato M., Giasotto V., Zawaideh J.P., Tomasello L., Mantica G., Piol N., Borghesi M., Traverso P., Satragno C., Panarello D., Scaffidi C., Romagnoli A., Rebuzzi S.E., Coco A., Spina B., Morbelli S., Sambuceti G., Terrone C., Barra S., Fornarini G, & Bauckneht M. (2023). Oligometastatic Prostate Cancer Treated with Metastasis-Directed Therapy Guided by Positron Emission Tomography: Does the Tracer Matter?. Cancers, 15(1), 323.

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PET/MRI Imaging of FDG Biodistribution

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All patients had fasted for at least 6 hours before and had blood glucose levels in the reference range. After the intravenous injection of mean 350 ± 20 MBq ¹⁸F-FDG the patients underwent a standard whole-body PET/CT scan (Hi-Rez Biograph 16 or Biograph mCT; Siemens Healthineers, Knoxville, USA) followed by a simultaneous whole-body PET/MRI examination (Biograph mMR; Siemens Healthineers, Erlangen, Germany). Positron emission tomography and MR imaging were started simultaneously 123 ± 8.4 minutes p.i., with 6 minutes per bed. The PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets and a 3-mm Gaussian filter (image matrix, 256 × 256; voxel size, 1.78 × 1.78 × 2 mm). The PET attenuation correction was accomplished by a MR-based attenuation map from segmented MR images. During each PET data acquisition, axial ss-EPI sequences were acquired under free breathing with the following parameters: TR = 13300 ms, TE = 76 ms, b = 0 and 800 s/mm², STIR fat saturation, matrix size = 104 × 138 pixels, voxel size 2.8 × 2.8 × 6.0 mm³, 3 averages, parallel imaging acceleration factor = 2, and acquisition time 3:20 min per bed.

Sauter A.W., Stieltjes B., Weikert T., Gatidis S., Wiese M., Klarhöfer M., Wild D., Lardinois D., Bremerich J, & Sommer G. (2017). The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of 18F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors. Contrast Media & Molecular Imaging, 2017, 8650853.

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FDG PET/CT Staging Protocol for Primary Tumour

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370 MBq of 18F FDG injected intravenously after at least six hours of fasting and when blood glucose level was lower than 200 mg/dL. One hour after 18F FDG injection, a total body CT scan without IV contrast agent and whole-body 3D PET acquisition with 8 bed positions of 3 min of emission scan time, covering the area from the vertex to the proximal thigh, each using a dedicated PET/CT scanner (HI-REZ Biograph 16, SIEMENS) which provides an in-plane spatial resolution of 4.8 mm, an axial field view of 16.2 cm. The PET data were reconstructed using a Gaussian filter with an ordered-subset expectation maximization algorithm (3 iterations, 8 subsets), re-oriented in transverse, coronal and sagittal planes.
PET scans were analyzed visually and semi-quantitatively using SUV_max measurement. One experienced nuclear medicine expert reviewed blindly and independently the FDG PET/CT scans regardless of as positive or negative for a primary tumour site. It was thought that ingestion of any radioactive substance that deviated from the physiological distribution was in favor of the spread of the disease.

Öztürk H, & Karapolat İ. (2023). Evaluation of response to gemcitabine plus cisplatin-based chemotherapy using positron emission computed tomography for metastatic bladder cancer. World Journal of Clinical Cases, 11(36), 8447-8457.

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FDG-PET Imaging Protocol for Bone Lesion Analysis

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FDG-PET was performed according to the European Association of Nuclear Medicine (EANM) Guidelines [24 (link)]. PET/CT scans were performed using a 16-slices PET/CT hybrid system (Hirez-Biograph 16, Siemens Medical Solutions, USA).
FDG-PET images were interpreted in consensus by three expert nuclear medicine physicians (M.B.; M.I.D.; A.M.) blinded to contrast-enhanced CT and bone scan results. From the attenuation corrected FDG-PET images, the maximum standardized uptake value (SUVmax) of the hottest bone lesion was obtained in the transaxial view. Further, a volume of interest was drawn using an SUV-based automated contouring program (Syngo Siemens workstation, Siemens Medical Solutions, USA) with an isocounter threshold based on 40% of the SUVmax, as previously recommended [25 (link)]. Total Metabolic Tumor Volume (MTV) was obtained by the sum of all skeletal and extra-skeletal lesions. Total Lesion Glycolysis (TLG) was calculated as the sum of the product of MTV of each lesion, and the SUVmean value, which, in turn, was automatically calculated within each single MTV.
Aiming to analyze the interobserver variation, a second expert PET reader (S.M.) measured MTV and TLG independently from the first group of observers.

Bauckneht M., Rebuzzi S.E., Signori A., Donegani M.I., Murianni V., Miceli A., Borea R., Raffa S., Damassi A., Ponzano M., Catalano F., Martelli V., Marini C., Boccardo F., Morbelli S., Sambuceti G, & Fornarini G. (2020). The Prognostic Role of Baseline Metabolic Tumor Burden and Systemic Inflammation Biomarkers in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Radium-223: A Proof of Concept Study. Cancers, 12(11), 3213.

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Brain PET/MR Imaging Protocol

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The measurements were performed with a clinical brain PET/MR imaging system (BrainPET, Tim Trio MR; Siemens Healthcare). The PET scanner (16) was mounted inside a 3-tesla MR scanner. The spatial resolution in the center was 2.3, 3.1, and 2.6 mm in full width at half maximum in the x, y, and z directions, respectively (16) . Acquired list-mode data were reconstructed using an ordinary Poisson ordered-subsets expectation maximization 3-dimensional algorithm (6 iterations and 16 subsets) (17) . The z-axis of the scanner was defined as aligned with the magnetic field. Additional measurements were performed with a clinical PET/CT (18) Hi-Rez Biograph 16 (Siemens Medical Solutions) with a spatial resolution of about 4 mm.

Kolb A., Sauter A.W., Eriksson L., Vandenbrouke A., Liu C.C., Levin C., Pichler B.J, & Rafecas M. (2015). Shine-Through in PET/MR Imaging: Effects of the Magnetic Field on Positron Range and Subsequent Image Artifacts. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6).

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Estimating Global Cortical Amyloid Burden

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To estimate global cortical amyloid burden, participants completed a [¹⁸F] florbetapir PET on a Siemens Biograph 16 HiRez PET/CT scanner at the Banner Alzheimer’s Institute (Arizona, USA). Three individuals, including one mutation carrier and two non-carriers, did not complete the amyloid PET scan. Briefly, images were acquired following the intravenous injection of 10 mCi of [¹⁸F] florbetapir radiotracers, a 50-min radiotracer uptake period, a 10-min emission scan, and a CT scan for correction of radiation attenuation. Images were reconstructed using an iterative algorithm, with attenuation–correction and a 5-mm full-width-at-half-maximum Gaussian filter.
Using a SPM12‐based pipeline, PET images were first aligned to a standard brain atlas. The quantification of the global cortical amyloid burden was obtained following a previously described method [24 (link)]. In brief, cortical-to-pontine standard uptake value ratios (SUVRs) were extracted and averaged across six pre-defined cortical regions of interest regrouping frontal, temporal, parietal, anterior cingulate, posterior cingulate, and precuneus regions.

Schoemaker D., Zanon Zotin M.C., Chen K., Igwe K.C., Vila-Castelar C., Martinez J., Baena A., Fox-Fuller J.T., Lopera F., Reiman E.M., Brickman A.M, & Quiroz Y.T. (2022). White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia. Alzheimer's Research & Therapy, 14, 89.

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Multimodal Neuroimaging of Alzheimer's Disease

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NWSI was piloted using a database of MRI and amyloid PET images obtained through 1Florida ADRC. For this pilot project, currently 273 structural MRI, 43 18F-Florbetapir PET scans, and 89 18F-Florbetaben PET scans are available. The MRI images were obtained using a Siemens Medical System Skyra 3 Tesla Scanner. The DTI scans were used to measure radial, axial, and mean diffusivity, as well as fractional anisotropy (FA). PET images were obtained from a Siemens Biograph 16 Hi-Rez PET-CT machine.

Lizarraga G., Li C., Cabrerizo M., Barker W., Loewenstein D.A., Duara R, & Adjouadi M. (2018). A Neuroimaging Web Services Interface as a Cyber Physical System for Medical Imaging and Data Management in Brain Research: Design Study. JMIR Medical Informatics, 6(2), e26.

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PET/CT Imaging for Lymphoma Evaluation

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Patient preparation included fasting for at least 6 h, adequate hydration, blood glucose measurement, and an intravenous injection of 18F-FDG whose dose depended on the tomograph and the patient’s weight, with subsequent uptake time of 45–60 min. In all centers, patients were instructed to void before imaging acquisition, and no oral or intravenous contrast agents were administrated or bowel preparation used for any patient. The PET/CT scanner was a Discovery PET/CT system (Bari: GE Healthcare, Milwaukee, WI, USA; Novara and Firenze: Siemens Biograph 16 Hi Rez, Knoxville, TN, USA; Kyiv: Siemens Biograph 64, Munich, Germany). Supine decubitus under the scanner with arms in front of the pelvis is the position chosen for optimal image reading and interpretation and to avoid overlapping the arms with the spine. The fields of view include from the skull to the mid-thigh (5–7 bed positions). The Discovery system includes a multidetector helical CT scanner. We evaluated gastric and colorectal positivities. Every radiotracer uptake deviating from physiologic distribution and background was regarded as suggestive of lymphoma.
Both focal and diffuse GI 18F-FDG uptakes were considered for the analysis.

Skrypets T., Ferrari C., Nassi L., Margiotta Casaluci G., Puccini B., Mannelli L., Filonenko K., Kryachok I., Clemente F., Vegliante M.C., Daniele A., Sacchetti G., Guarini A, & Minoia C. (2021). 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis. Journal of Personalized Medicine, 11(2), 123.

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Ga-68 Citrate PET/CT and PET/MR Imaging

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Patients were injected with up to 15 mCi (555 MBq) (average 7.42 mCi [274.6 MBq], range 3.7 to 11.9 mCi [136.9 to 438.5 MBq]) ⁶⁸Ga-citrate intravenously. PET acquisition was acquired between 120 and 263 minutes after injection (average 210 minutes). Images were acquired on either a PET/CT or PET/MR. PET/CT examinations were performed on either a Biograph 16 (Hi-Rez) PET/CT scanner (Siemens AG, Erlangen, Germany) with an integrated PET and 16-MDCT scanner or a Discovery VCT PET/CT scanner (GE Medical Systems, Milwaukee, WI) with an integrated PET and 64-MDCT scanner. A low-dose CT was acquired for PET attenuation correction. PET/MR images were performed on a SIGNA PET/MR (GE Medical Systems, Milwaukee, WI). Attenuation correction for PET reconstruction was performed using a MR-based attenuation correction (MRAC) technique provided by the scanner manufacturer.

Aggarwal R., Behr S.C., Paris P., Truillet C., Parker M.F., Huynh L.T., Wei J., Hann B., Youngren J., Huang J., Ranatunga N., Chang E., Gao K.T., Ryan C.J., Small E.J, & Evans M.J. (2017). Real time transferrin-based PET detects MYC-positive prostate cancer. Molecular cancer research : MCR, 15(9), 1221-1229.

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