C 129s2 stat6tm1gru j

Manufactured by Jackson ImmunoResearch

The C.129S2-Stat6tm1Gru/J is a laboratory mouse strain with a targeted mutation in the Stat6 gene. This strain is useful for the study of immune system function and regulation.

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Lab products found in correlation

B6.129s4 c3tm1crr j, by Jackson ImmunoResearch (1 mentions) C 129s4 c3ar1tm1cge j, by Jackson ImmunoResearch (1 mentions) Balb c il4ratm1sz j, by Jackson ImmunoResearch (1 mentions) C57bl 6 mice, by Jackson ImmunoResearch (1 mentions)

3 protocols using c 129s2 stat6tm1gru j

Transgenic Mouse Models for Tumor Research

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BALB/c (BALB/c J), MMTV-PyMT (FVB/N-Tg (MMTV-PyVT) 634Mul/J), FVB (FVB/NJ), Nude (NU/J), Stat6^−/− (C.129S2-Stat6^tm1Gru/J), T-bet^−/− (C.129S6-Tbx21^tm1Glm/J), C3^−/− (B6.129S4-C3^tm1Crr/J), and C3aR^−/− (C.129S4-C3ar1^tm1Cge/J) mice were obtained from the Jackson Laboratory and bred in a specific pathogen-free animal facility of Soochow University (temperature 22 °C, humidity 59 rH using a 12/12 h dark/light cycle). The animal protocols for the experiments described in this study were approved by the Ethical Committee of Soochow University.

Zheng Z., Li Y.N., Jia S., Zhu M., Cao L., Tao M., Jiang J., Zhan S., Chen Y., Gao P.J., Hu W., Wang Y., Shao C, & Shi Y. (2021). Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nature Communications, 12, 6202.

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Genetically Modified Mouse Models

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Female BALB/cAnNCr mice between 6–8 wk old were purchased from the National Cancer Institute (Frederick, MD). Eosinophil-deficient dblGATA-1 (C.Cg-Gata1^tm6Sho/J) [19 (link)] and STAT6-deficient mice (C.129S2-Stat6^tm1Gru/J) on the BALB/c background were purchased from The Jackson Laboratory (Bar Harbor, ME). IFN-γ-deficient mice (C.129S7(B6)-Ifng^tm1Ts/J) on the BALB/c background was obtained from John T. Harty (University of Iowa).

Knudson C.J., Hartwig S.M., Meyerholz D.K, & Varga S.M. (2015). RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets. PLoS Pathogens, 11(3), e1004757.

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Immunological Evaluation of Genetically Modified Mice

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Six- to eight-week old male and female Balb/c and C57BL/6 mice, IL-4 receptor^−/− (IL-4R^−/−, BALB/c-Il4ra^tm1Sz/J, stock no. 003514) and STAT6^−/− (C.129S2-Stat6^tm1Gru/J, stock no. 002828) mice were obtained from Jackson Laboratory (Bar Harbor, ME) or Harlan Laboratories (Madison, WI). CD1d^−/− mice were generously donated by Drs. Stephen Jameson and Kris Hogquist at the University of Minnesota Center for Immunology. Mice were group housed under a 12/12 h standard light/dark cycle and fed standard mouse chow ad libitum. Testing occurred during the light phase.

Crouse B., Robinson C., Huseby Kelcher A., Laudenbach M., Abrahante J.E, & Pravetoni M. (2020). Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders. NPJ Vaccines, 5, 99.

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