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128 protocols using verio scanner

1

Cardiac MRI Imaging Protocol for Surgical Patients

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Each patient underwent cardiac MRI twice: within 6 weeks before surgery and from 5 days after surgery. Patients were scanned using a research-dedicated 3T Siemens Verio scanner (Siemens Medical, Germany). Quantification of LV mass, EF and late gadolinium enhancement infarct size were determined using established protocols and dedicated cardiac analysis software by two trained independent blinded observers.
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2

Multimodal Neuroimaging of Cognitive Processing

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MEG data were obtained using a whole-cortex 275-channel system (VSM MedTech Inc., Coquitlam, BC) in a magnetically shielded room. Prior to data acquisition, three head-position indicator coils were attached to the participant's scalp at the nasion and left- and right-preauricular points. These head coils provided continuous specification of head position and orientation in relation to the MEG sensors. To minimize fatigue during the task, participants viewed (but did not listen to) a movie projected onto a screen positioned at a comfortable viewing distance. Electrodes were attached to the left and right clavicles for electrocardiogram recordings (ECG) and to the bipolar oblique (upper and lower left sites) for electro-oculogram recordings (EOG). A band-pass filter (0.03–300 Hz) was applied to the EOG, ECG, and MEG signals, with signals digitized at 1200 Hz, and with third-order gradiometer environmental noise reduction of the MEG data.
After the MEG session, structural magnetic resonance imaging (sMRI) including T1-weighted, 3D MP-RAGE anatomical images for source localization was acquired on a 3 T Siemens Verio™ scanner (Siemens Healthcare, Erlangen, Germany) with voxel size 0.8 × 0.8 × 0.9 mm3.
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3

Functional MRI Protocol for Brain Imaging

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Functional magnetic resonance imaging (fMRI) data was acquired for two runs, using a 3 T Siemens Verio scanner (Siemens Medical Systems, Erlangen), equipped with a 32-channel head coil. T2*-weighted echoplanar images with blood-oxygen-level-dependent contrast were obtained (TR = 2 s, TE = 27 ms, matrix size = 70 × 70, number of slices = 37, slice thickness = 3 mm, FoV = 210, flip angle = 90°). A high quality T-1 weighted image was available from the in-house database (TR = 2.3 s, TE = 2.98 ms, slices = 176, slice thickness = 1 mm, voxel volume = 1 × 1 × 1 mm, FOV = 256 mm2, flip angle = 9°) for each participant so that no additional T-1 weighted image for anatomical reference was acquired.
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4

Structural MRI Acquisition for Pediatric Epilepsy

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Structural MR images were obtained on a 3 Tesla Siemens Verio scanner (Siemens AG, Munich, DE) or GE Signa HDxt scanner (General Electric, Milwaukee, WI) in all children utilizing sedation. In the Siemens Verio scanner, a T1-weighted 3D Stealth sequence was acquired using a 12-channel head coil (TR/TE/flip angle = 1900/2.93/9°) with slice-select inversion recovery pulses (TI = 900 ms), FOV = 512 x 512 x 176, and voxel size 0.5 × 0.5 × 1 mm. In the GE Signa HDxt scanner, a T1-weighted 3D Fast Spoiled Gradient-echo (FSPGR) sequence was acquired using an 8-channel head coil (TR/TE/flip angle = 7.95/3.56/12°), FOV = 512 × 512 × 220, and voxel size 0.5 × 0.5 × 0.8 mm. The anatomical MRI was used for neuro-navigation during TMS sessions. During the same MRI session, patients also completed other clinical MRI and fMRI sequences as part of their epilepsy evaluation.
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5

Neuroimaging Protocols for Electrode Implantation

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The following neuroimaging protocols were used on all the participants in the study: high-resolution 3D T1-weighted magnetization prepared rapid gradient echo (T1WI MPRAGE) sequencing [repetition time (TR) 2,300 ms, echo time (TE) 2.53 ms, flip angle 12°, slice thickness 1 mm, no gap, voxel size 1 mm × 1 mm × 1 mm] with a 3T Siemens Verio scanner (Siemens Healthineers, Erlangen, Germany). CT scans (120 kVp, field of view 320 mm, matrix 512×512, slice thickness 0.625 mm; LightSpeed VCT, GE Healthcare, Chicago, IL, USA) were also obtained. The data were collected on the same day of the electrode implantation to confirm the electrode locations and prevent potential complications, such as hematoma and electrode displacement, as part of the routine clinical procedure.
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6

Multimodal MRI Imaging Timepoints

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Patients were imaged at presentation, 24‐h (18–48 h), 1‐week (3–9 days), and 1‐month (14–42 days) timepoints, whenever possible. All scans were acquired using a 3.0T Siemens Verio scanner (Siemens Healthcare, Erlangen, Germany). Scanning protocols included diffusion‐weighted imaging (3 directions, 1.8 × 1.8 × 2.0 mm, FoV = 240 mm, 4 averages, b = 0 and 1000 sec/mm2, repetition time = 9000 msec, TE = 98 msec, 50 slices, 2 min 53 sec) with apparent diffusion coefficient calculation and T1‐weighted structural imaging (MPRAGE, 1.8 × 1.8 × 1.0 mm, FoV = 228 mm, TR = 2040 msec, TE = 4.55 msec, 3 min 58 sec) at all timepoints; and T2‐weighted turbo spin echo FLAIR (1.9 × 1.9 × 2.0 mm, FoV = 240 mm, TR = 9000 msec, TE = 96 msec, TI = 2500 msec) at 1‐week and 1‐month timepoints. When intravenous thrombolysis was indicated the presenting MRI scan occurred during the alteplase infusion. For patients presenting beyond the time window for thrombolysis the presenting MRI was acquired as soon as possible after admission.
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7

Multimodal MRI of Intracerebral Hemorrhage

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For all participants, MRI were performed within 6 days of admission. Images were obtained with two 3T MRI scanners, GE Discovery 750 scanner (GE Healthcare, Milwaukee, Wis) and Siemens verio scanner (Siemens, Erlangen, Germany). The MRI ICH protocols are similar in two MRI scanners, including the following sequences: whole brain T1 weighted image (T1W; repetition time/echo time 1,900/9.4 ms; 5 mm slice thickness, 6 mm interslice gap), T2-weighted image (T2W; repetition time/echo time 6,000/97 ms, 5 mm slice thickness, 6 mm interslice gap), and fluid-attenuated inversion recovery (FLAIR; repetition time/echo time 7,800/91 ms, inversion time 2,200 ms, 5 mm slice thickness, 6 mm interslice gap) and susceptibility-weighted imaging (SWI; repetition time/echo time 28/20 ms, flip angle 15°, 1.6 mm slice thickness, 0.3 mm interslice gap).
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8

Quantifying Dexamethasone and Metabolite via 19F MRI

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A 3T Siemens Verio scanner (Siemens Healthineers, Erlangen, Germany) with a circularly polarized 19F-tuned transmit-receive flexible surface coil (180 mm × 244 mm, Rapid Biomedical, GmbH, Rimpar, Germany) was used for scanning phantom solutions of dexamethasone and 11-dehydrodexamethasone prepared in methanol (20 mL in glass vials). Saline bottles were used to load the coil and the phantom was placed between the loading bottles and the coil. Spectra ranging from 64 to 640 averages were used to measure LODF and signal-to-noise versus tracer content using pulse-acquire scans. TR of 0.5, 1 and 1.5 s were tested and the shortest one that did not affect signal to noise used.
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9

Neonatal Brain Metabolite Profiles

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Lambs were lightly sedated with medetomidine hydrochloride (0.1 mg/kg, Domitor, Pfizer, West Ryde, NSW, Australia), and magnetic resonance spectroscopy (MRS) scans undertaken at 12 and 72 hours after birth in a 3T Siemens Verio scanner (Siemens Healthcare, Bayswater, Vic., Australia), with an 8‐channel knee coil utilising a 2 cm3 D voxel in the deep grey matter of the brain. For each metabolite (lactate, choline and n‐acetyl‐aspartate [NAA]), the relative concentrations were measured by computer algorithm of peak area under the MRS curve. The ratios of the 3 metabolites of interest, (NAA:choline, lactate:choline and lactate:NAA) at 12 and 72 hours were calculated. MRS was not undertaken on asphyxia+MLT‐P lambs, but all other neurological outcomes are presented.
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10

Brain MRI Acquisition Protocol

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All participants underwent brain MRI scans at both time points on the same 3T Verio Siemens scanner (Siemens, Erlangen, Germany). The details of brain MRI imaging protocol have been described previously [9 (link)]. Briefly, both sagittal and axial T1-weighted three-dimensional (3D) magnetization prepared rapid gradient echo (MPRAGE) imaging data were acquired. A 3D fluid-attenuated inversion recovery (FLAIR) sequence was obtained to rule out incidental brain pathology.
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