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Glyceryl behenate

Manufactured by Gattefosse
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Sourced in Germany, France

Glyceryl behenate is a lipid-based excipient commonly used in pharmaceutical and cosmetic formulations. It serves as a lubricant, binder, and emulsifier, helping to improve the physical and textural properties of various products.

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Lab products found in correlation

Tween 80, by NOF corporation (3 mentions) Span 80, by NOF corporation (3 mentions) Sodium lauryl sulfate, by BASF (1 mentions) Colloidal silicon dioxide, by Evonik (1 mentions) Sodium stearyl fumarate, by JRS Pharma (1 mentions) Low substituted hydroxypropyl cellulose l hpc, by Shin-Etsu Chemical (1 mentions) Copovidone, by BASF (1 mentions) Magnesium stearate, by Mallinckrodt (1 mentions) Crospovidone, by BASF (1 mentions) Polysorbate 80, by Merck Group (1 mentions) Poloxamer 188, by Merck Group (1 mentions) 5 cqa, by Merck Group (1 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Ascorbic acid, by Merck Group (1 mentions) Nacdc, by Merck Group (1 mentions) Hydrogenated castor oil, by BASF (1 mentions) Plasacryl htp20, by Evonik (1 mentions) Acryl eze 93 a, by Colorcon (1 mentions) Eudragit polymers, by Evonik (1 mentions) Carbopol 71g, by Lubrizol (1 mentions)

4 protocols using glyceryl behenate

1

Formulation and Evaluation of Clopidogrel-Rosuvastatin Tablet

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Clopidogrel bisulfate and rosuvastatin calcium were purchased from Dr. Reddy’s Laboratory Ltd. (Hyderabad, India) and TEVA Pharmaceutical Industries Ltd. (Petah Tikva, Israel), respectively. Low-substituted hydroxypropyl cellulose (L-HPC) was obtained from Shin-Etsu Chemical (Tokyo, Japan). Copovidone, crospovidone, and sodium lauryl sulfate were purchased from BASF (Ludwigshafen, Germany). Lactose monohydrate (Meggle Pharma, Wasserburg, Germany), colloidal silicon dioxide (Evonik, Essen, Germany), talc (Nippon Talc, Osaka, Japan), magnesium stearate (Mallinckrodt Pharmaceuticals, Staines, UK), carnauba wax (SS Pharm Co., Ansan, South Korea), sodium stearyl fumarate (JRS Pharma, Rosenberg, Germany), glyceryl behenate (Gattefosse, Saint-Priest, France), titanium dioxide (Kronos Inc., Chelmsford, MA, USA), sodium starch glycolate (DFE Pharma, Goch, Germany), and croscarmellose sodium (FMC Co., Philadelphia, PA, USA) were also purchased from the corresponding companies as indicated in parentheses. All other chemicals and reagents were of analytical grade.
Seo K.S, & Han H.K. (2019). Multilayer-Coated Tablet of Clopidogrel and Rosuvastatin: Preparation and In Vitro/In vivo Characterization. Pharmaceutics, 11(7), 313.
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2

Cytotoxicity Evaluation of Bioactive Compounds

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The following chemicals were used in this study: glyceryl behenate (Gattefossé, Saint-Priest, France); poloxamer 188, polysorbate 80, ˪-ascorbic acid, and 5CQA (Sigma-Aldrich Company, St. Louis, MO, USA); glyceryl monostearate (BDH Chemicals Ltd, Poole, England); caprylic/capric triglycerides (INOLEX Company, Bangkok, Thailand); H2O2 (Carlo Erba Reagents S.A.S., Val de Reuil, France); and Dulbecco’s modified Eagle’s medium (DMEM), fetal bovine serum (FBS), penicillin-streptomycin, 0.25% trypsin-EDTA, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) (Gibco-BRL, Grand Island, NY, USA). All the chemicals used were of analytical grade.
Navabhatra A., Brantner A, & Yingngam B. (2021). Artificial Neural Network Modeling of Nanostructured Lipid Carriers Containing 5-O-Caffeoylquinic Acid-Rich Cratoxylum formosum Leaf Extract for Skin Application. Advanced Pharmaceutical Bulletin, 12(4), 801-817.
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3

Formulation and Manufacture of MEDI7219 Tablets

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MEDI7219 was manufactured by Bachem (Bubendorf, Switzerland). The permeation enhancers Na CDC and PG were purchased from Sigma-Aldrich (St. Louis, MO, USA). Eudragit polymers and PlasACRYL HTP 20 were purchased from Evonik (Allentown, PA, USA). Mucoadhesive polymer Carbopol 71G was purchased from Lubrizol (Wickliffe, OH, USA). HPMC Hypromellose K4M and Acryl-eze 93A were purchased from Colorcon (Harleysville, PA, USA). Glyceryl behenate was purchased from Gattefossé (Eschbach, Germany). Hydrogenated castor oil was purchased from BASF (Ludwigshafen, Germany). Low-substituted hydroxypropyl cellulose (LH-21 and LH-32) was purchased from Shin-Etsu (Tokyo, Japan). Simethicone was purchased from Basildon (Abingdon, UK). All other ingredients were purchased from Sigma-Aldrich. The OralogiK time-delayed tablets were designed and manufactured by BDD Pharma (Scotland, UK).
Tyagi P., Patel C., Gibson K., MacDougall F., Pechenov S.Y., Will S., Revell J., Huang Y., Rosenbaum A.I., Balic K., Maharoof U., Grimsby J, & Subramony J.A. (2023). Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation. Pharmaceutics, 15(10), 2436.
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4

Topical Chili Extract Formulation

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Capsaicin standard and capsicum oleoresin extract (chili extract) were obtained from Bangkok Lab and Cosmetic, Ratchaburi, Thailand. Glyceryl behenate (GBH), or Compritol® 888ATO, was obtained from Gattefossé (Lyon, France). Glyceryl monostearate (GMS), cetyl alcohol (COH), stearyl alcohol (SOH), isopropyl myristate (IPM), and jojoba oil were purchased from Namsiang (Bangkok, Thailand). Tween® 80 and Span® 80 were purchased from NOF Corporation (Tokyo, Japan). Acetonitrile, methanol (HPLC grade), glacial acetic acid, ethanol (AR grade), and deionized water were purchased from RCI Labscan (Bangkok, Thailand). Carbopol 940 was purchased from Universal Preserv-A-Chem (NJ, USA). High-viscosity hydroxypropyl methyl cellulose (HV HPMC, viscosity 2600–5600 cP) and isopropanol were purchased from Sigma-Aldrich (MO, USA). Triethanolamine (TEA) was purchased from Fisher Scientific (PA, USA). The fully differentiated human epidermis (EpiDermTM) specimen, EpiDerm culture medium, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay kit were purchased from MatTek Corporation (MA, USA). Quantikine® human Interleukin 1 alpha (IL-1 α) ELISA kit was purchased from R&D Systems (MN, USA).
Anantaworasakul P., Chaiyana W., Michniak-Kohn B.B., Rungseevijitprapa W, & Ampasavate C. (2020). Enhanced Transdermal Delivery of Concentrated Capsaicin from Chili Extract-Loaded Lipid Nanoparticles with Reduced Skin Irritation. Pharmaceutics, 12(5), 463.
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