Symbia intevo 16

Manufactured by Siemens

Sourced in Germany

The Symbia Intevo 16 is a hybrid imaging system that combines single-photon emission computed tomography (SPECT) and computed tomography (CT) technologies. It is designed to provide high-quality diagnostic imaging for a wide range of clinical applications.

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Lab products found in correlation

Aquilion prime, by Canon (1 mentions)

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Symbia Intevo 16 Bold SPECT scanner Symbia Intevo Intevo 16 Intevo Symbia

5 protocols using symbia intevo 16

Q-SPECT/CT Imaging Protocol for Lung Perfusion

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Q-SPECT/CT was performed in accordance with the recommended guidelines and protocols [23 (link)]. Patients were administered with 185 MBq of 99mTc-macroaggregated albumin (MAA) (Pulmocis®, IBA). Image acquisition was performed within 5 min post-injection on a dedicated Siemens Symbia Intevo 16. Multiple planar projections were acquired followed by SPECT and free-breathing non-contrasted LDCT.
For SPECT acquisition, a general purpose collimator, 128 × 128 matrix, was used. A peak window of 15% width was centred around the 140-keV energy peak. The total number of projections is 32, at 20 s per projection. For CT imaging, 130 kV and 75 mAs/slice were used. Attenuation and scatter correction were performed using CT-based attenuation-corrected maps.
SPECT images were reconstructed with an ordered-subset expectation maximisation (OSEM) 3-D algorithm (4 subsets, 4 iterations, 8.40 Gausian filter). CT transverse images were reconstructed at 1.5-mm section thicknesses, using reconstruction kernels of sharp resolution (Siemens B75f).

Tan T.H, & Ismail R. (2022). Utility of Lung Perfusion SPECT/CT in Detection of Pulmonary Thromboembolic Disease: Outcome Analysis. Nuclear Medicine and Molecular Imaging, 57(1), 1-8.

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SARS-CoV-2 Transmission Risk in CT Scans

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For this monocentric prospective observational pilot study, we took swab samples from two CT scanners before and after scanning patients with SARS-CoV-2-positive throat swabs in a university medical center between February and May 2021. One of these CT scanners was an 80-slice machine (Canon Aquilion PRIME, Canon Medical Systems), the other a 16-slice scanner (Symbia Intevo 16, Siemens Healthcare GmbH).
Inclusion criteria for the study were patient age over 17 years and SARS-CoV-2 infection, confirmed by RT-PCR (real-time reverse-transcription polymerase chain reaction), with ongoing isolation and positive SARS-CoV-2 RT-PCR in the most recently taken throat swap. Patients were grouped into invasively ventilated and non-invasively ventilated or non-ventilated patients to segregate effects from closed ventilation systems in patients with SARS-CoV-2, which is mainly transmitted through respiratory particles [2 (link)]. The local ethics committee approved this anonymous observational study and provided a waiver for written informed consent (EA1/085/21).

Göhler F., Corman V.M., Bleicker T., Stroux A., Dewey M, & Diekhoff T. (2022). Contamination of CT scanner surfaces with SARS-CoV-2 and infective potential after examination of invasively ventilated, non-invasively ventilated and non-ventilated patients with positive throat swabs: prospective investigation using real-time reverse-transcription PCR and viral cell culture. Insights into Imaging, 13, 61.

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Salivary Gland Scintigraphy Protocol

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All patients fasted for at least 4 h before the injection of radiopharmaceutical. Scanning began at the time of the intravenous injection of 555 MBq of Tc-99 m pertechnetate (^99mTcO4^-) using a gamma camera (Symbia Intevo 16, Siemens Medical Solutions, Munich, Germany, 2016) with an energy peak setting of 140 keV ± 7.5% for Tc-99 m. Twenty dynamic perfusion images were obtained for 3 s per image. Static images were collected at 5-min, 10-min, 20-min, and 40-min after injection and acquired for 90 s per image. At 5-min and 10-min, only anterior images were obtained, while at 20-min and 40-min, right lateral and left lateral images were obtained as well (Fig. 1). After acquiring the 40-min images, the patients drank 200 mL of orange juice as a sialagogue. Then, anterior and bilateral lateral images labeled 'wash-out images' were acquired to evaluate the salivary gland response to sialagogue. All patients underwent pre-treatment and post-treatment salivary scintigraphy.

Hwang J.H., Han Y.H., Rahman M.T, & Lee C.S. (2021). Quantitative assessment of dry mouth in scrub typhus using salivary scintigraphy. Scientific Reports, 11, 23633.

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Bone Metastasis in Prostate Cancer

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This study was approved by the Ethics Committee at the Renji Hospital, Shanghai Jiao Tong University School of Medicine, China. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Venous blood samples (5 mL) were collected in non-anticoagulant acquisition tubes (GD050A, Gongdong Comp. Zhejiang, China) for serum extraction (1 mL) one day before prostate biopsy. The coagulation of each sample was carried out at room temperature for 30 min and then the centrifugation (2000 g, 10 min, 4 °C) was performed to extract the serum. All of the serum samples were stored at -80 °C (no more than 6 month) in EP tube till bone metastasis of patients was confirmed by whole body bone scan (Symbia Intevo 16, Siemens) at Renji Hospital. Samples from newly diagnosed patients with untreated bone metastatic prostate cancer were selected in our study. According to general consensus in the clinical practice, the indolent prostate cancer is referred to the prostate cancer with Gleason Score 6, and the aggressive prostate cancer is referred to the prostate cancer with Gleason Score > 6.

Wang Y., Fang Y.X., Dong B., Du X., Wang J., Wang X., Gao W.Q, & Xue W. (2021). Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer. Theranostics, 11(2), 878-892.

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Lung Perfusion Scintigraphy and SPECT/CT in COPD

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Lung perfusion SPECT/CT was performed in the seven COPD patients as part of the routine clinical workup using a standard administered dose of 111 MBq 99m Tc-MAA. The scintigraphy and SPECT were acquired on a double-head SPECT/CT scanner (Symbia Intevo 16, Siemens Healthineers, Forchheim, Germany). Three-dimensional ordered subset expectation maximization (OSEM) with 4 subsets, 8 iterations and 4 mm Gaussian filtering was used for reconstruction. The voxel size was isotropic 4.8 mm.
The acquisition time for SPECT was 20 min. The CT scans followed a low dose protocol with 130 kV and 30 mAs reference values resulting in a total dose-length product (DLP) of ~100 mGycm. CT-data were reconstructed using filtered back projection with a B70s convolution kernel. The slice thickness was 1.5 mm and the in-plane resolution was 0.7×0.7 mm 2 .

Pusterla O., Sommer G., Santini F., Wiese M., Lardinois D., Tamm M., Bremerich J., Bauman G, & Bieri O. (2018). Signal enhancement ratio imaging of the lung parenchyma with ultra-fast steady-state free precession MRI at 1.5T. Journal of magnetic resonance imaging : JMRI, 48(1).

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