PET/ceCT studies were performed using 2 similar Siemens Biograph PET/CT systems (Siemens, Erlangen, Germany). Of the 90 patients randomized to the PET/ceCT branch, 80 patients (80/90 [89.5%]) were scanned in a PET/CT system with a 6-detector row CT (Biograph 6 TruePoint; Siemens) with a theoretical 3D PET spatial resolution of 3 to 4 mm. It includes 4 rows of detectors with LSO crystals with topogram CT dose modulation. The remaining 10 patients (10/90 [10.5%]) were scanned with a 16-detector-row CT (Biograph 16; Siemens), with no differences in the other technical factors. The FDG PET/ceCT procedure was similar for all the patients in all centers.
Biograph pet ct system
Manufactured by Siemens
Sourced in Germany, United States
The Biograph PET/CT system is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to provide detailed diagnostic information by capturing both functional and anatomical data about the human body.
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7 protocols using biograph pet ct system
1
PET/ceCT Imaging Protocol Comparison
2
Dedicated Brain PET Imaging Protocol
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A dedicated [18F]-FDG Brain PET acquisition was performed in all recruited patients according to the European Association of Nuclear Medicine (EANM) guidelines on two Siemens Biograph PET/CT systems (16 and mCT Flow 40, respectively) in the same center [15 (link)]. Images preprocessing was conducted using Statistical Parametric Mapping software version 8 (SPM8; Wellcome TrustCenter for Neuroimaging, London, UK) [16 (link)]. See Supplementary Materials for further details.
3
FDG-PET Imaging Acquisition Protocol
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FDG-PET images were acquired on a Siemens/CTI Biograph PET/CT system, using intravenous administration of 5 mCi (185 million Bq) of FDG after a 30-min radiotracer uptake period when resting with open eyes in a darkened room, followed by a 30-min dynamic emission scan (six 5-min frames). Images were reconstructed with computed tomographic attenuation correction.
4
PET/CT Imaging Protocol for FDG Uptake
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The study was performed by dedicated PET/CT scanners (2007-2012, GE Discovery LS PET/CT system; after 2012, Siemens Biograph PET/CT system) according to standard protocol. All patients enrolled have received an intravenous injection of 0.1mCi/kg 18F-FDG after fasting for at least 6 hours. The blood glucose level of each patient was strictly confirmed under 150 mg/dL right before the injection. The patients were free to rest on the bed and relax for 45 to 60 min after the FDG administration. Diagnostic-quality unenhanced CT images were acquired before PET data acquisition and were used for attenuation correction in the PET image reconstruction.
5
Standardized PET/CT Imaging Protocol
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All PET/CT scans were performed using a Siemens Biograph PET/CT system in three cooperating nuclear medicine units (Siemens Biograph 2 PET/CT; Siemens Biograph Sensation 16 PET/CT; Siemens Biograph 64 True Point).
18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) was used as a tracer in all patients. Blood glucose levels were measured before performing the scan, and the examination was conducted only in patients with a glucose level <150 mL/dL.
After injecting 300–382 MBq 18F-FDG during the distribution phase, the patients were placed in a resting position to avoid any muscular activity. The PET/CT scan was performed 60–90 min after tracer injection. The CT scan was performed as a low-dose multi-slice CT with 2, 16, or 64 slices. The entire examination was conducted according to current guidelines.
18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) was used as a tracer in all patients. Blood glucose levels were measured before performing the scan, and the examination was conducted only in patients with a glucose level <150 mL/dL.
After injecting 300–382 MBq 18F-FDG during the distribution phase, the patients were placed in a resting position to avoid any muscular activity. The PET/CT scan was performed 60–90 min after tracer injection. The CT scan was performed as a low-dose multi-slice CT with 2, 16, or 64 slices. The entire examination was conducted according to current guidelines.
6
PET/CT Analysis of [18F]florbetaben Uptake
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We conducted PET/CT scans in the Nuclear Medicine Facility of the Policlinic Tor Vergata, Rome, Italy. The Siemens Biograph PET/CT system at Tor Vergata was used to assess [ F]florbetaben uptake.
All the subjects were injected intravenously with 295–320 MBq [ F]florbetaben and hydrated with 500 ml of saline (0.9% sodium chloride). PET/CT scan was started approximately 90 min after [ F]florbetaben injection. To avoid movement artifacts, four stacks of dynamic images (4 frames of 300 s each) were acquired in a 3D-mode standard technique.
The voxel size of PET image was mm . PET image reconstruction was performed using the three-dimensional ordered-subsets expectation maximization (OSEM) method with 4 subsets and 14 iterations.
All the subjects were injected intravenously with 295–320 MBq [ F]florbetaben and hydrated with 500 ml of saline (0.9% sodium chloride). PET/CT scan was started approximately 90 min after [ F]florbetaben injection. To avoid movement artifacts, four stacks of dynamic images (4 frames of 300 s each) were acquired in a 3D-mode standard technique.
The voxel size of PET image was mm . PET image reconstruction was performed using the three-dimensional ordered-subsets expectation maximization (OSEM) method with 4 subsets and 14 iterations.
7
Quantification of 18F-FDG Uptake in PET/CT Imaging
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The patients were instructed to abstain from food for a minimum 4 hours before the imaging. Blood glucose levels were quantified to confirm that all serum glucose levels were under 144 mg/dL before injection of 18F-FDG intravenously. Approximately 370 MBq (10 mCi) of 18F-FDG per patient was administered through the antecubital vein. Patients weighing above 70 kg were administered a dose of 444 MBq (12 mCi) 18F-FDG. Patients rested in a room for one hour after which a full-body imaging was taken. Whole body 18F-FDG PET/CT scans were obtained on a Biograph PET/CT system (Siemens Molecular Imaging, Hoffman Estates, IL, USA). The system consists of a full ring dedicated PET and a 2-slice spiral CT. Data were analyzed on an image fusion workstation (Symbia; Siemens Healthcare Sector, Erlangen, Germany). The administered activity, time of administration, and patient body weight were used for calculation of SUVmax.
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