Body weight (kg) and height (cm), and waist and hip circumference (cm) were measured to the closest 0.1 unit in duplicate and in underwear. A subgroup (n = 93) of the total PERSON study population (MUMC + participants) underwent a whole body 3T MRI scan (3T MAGNETOM Prisma fit, Siemens Healthcare). Analyses were performed using computational modeling (method by AMRA Medical AB, Linköping, Sweden [18 (link)]). Fat ratio: (%, total abdominal adipose tissue / (total abdominal adipose tissue + total thigh muscle volume)*100), VAT volume (L), abdominal subcutaneous adipose (aSAT) volume (L), thigh muscle fat (%), liver fat: (%), abdominal adipose tissue (AT) index (L/m2, (VAT + aSAT)/height2), weight-to-muscle ratio (kg/L, body weight/total muscle volume), thigh muscle volume (L), and thigh muscle volume Z-score (adjusted for sex and body size (height, body weight, BMI) invariant) were quantified. Participants underwent a dual-energy X-ray absorptiometry (DXA) (MUMC+, Discovery A, Hologic; WUR, Lunar Prodigy, GE Healthcare) to determine body fat %.
3t magnetom prisma fit
Manufactured by Siemens
Sourced in Germany
The 3T Magnetom Prisma Fit is a magnetic resonance imaging (MRI) system developed by Siemens. It operates at a magnetic field strength of 3 Tesla, providing high-resolution imaging capabilities. The system is designed to deliver robust and reliable performance for a variety of clinical applications.
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8 protocols using 3t magnetom prisma fit
1
Body Composition Analysis via MRI
2
Functional MRI Acquisition for Auditory Cortex Studies
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Scanning was conducted using a Siemens 3T Magnetom Prisma Fit equipped with a 32-channel head coil (Siemens Healthcare, Erlangen, Germany), at the Scannexus facilities (Maastricht, Netherlands). Structural whole-brain T1-weighted images were acquired with a single-shot echoplanar imaging (EPI) sequence [field of view (FOV) 256 mm; 192 axial slices; 1 mm slice thickness; 1 mm × 1 mm × 1 mm voxel size; repetition time (TR) of 2250 ms; echo-time (TE) 2.21 ms]. For the functional localizer task, T2-weighted EPI scans were collected (FOV 208 mm; 60 axial slices; 2 mm slice thickness; 2 mm × 2 mm × 2 mm voxel size; TE 30 ms; flip angle = 77°). To reduce scanner noise interference, auditory stimuli were presented via S14 MR-compatible earphones, fitted with foam earplugs (Sensimetrics Corporation). Furthermore, to provide relative silence during playback of auditory stimuli, a long inter-acquisition-interval was adopted where time between consecutive acquisition was delayed, resulting in a TR of 10 s. The delayed TR was timed to allow a 2,000 ms acquisition period during peak activation in the auditory cortex (Belin et al., 1999 (link); Hall et al., 1999 (link)).
3
fMRI Data Acquisition with Behavioral Responses
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The fMRI data were acquired using an MRI scanner Siemens 3T Magnetom Prismafit and a Siemens Head/Neck 64‐channel coil.
Behavioral responses of the participants were registered during the MRI sessions with one of the two MR‐compatible, optic‐fiber response devices, depending on the protocol: (a) a five‐button ergonomic pad (Current Designs, Package 932 with Pyka HHSC‐1x5‐N4); and (b) a pair of in‐house custom‐made sticks featuring one‐top button. MR‐Confon package was used as audio system in the MRI environment.
All sessions were conducted at the NeuroSpin platform of the CEA Research Institute, Saclay, France.
Behavioral responses of the participants were registered during the MRI sessions with one of the two MR‐compatible, optic‐fiber response devices, depending on the protocol: (a) a five‐button ergonomic pad (Current Designs, Package 932 with Pyka HHSC‐1x5‐N4); and (b) a pair of in‐house custom‐made sticks featuring one‐top button. MR‐Confon package was used as audio system in the MRI environment.
All sessions were conducted at the NeuroSpin platform of the CEA Research Institute, Saclay, France.
4
Multimodal Neuroimaging of Decision Making
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Anatomical and functional MRI data were collected on a Siemens 3T Magnetom Prisma Fit with a 64-channel phased-array head and neck coil (58 channels active for functional coronal imaging). High-resolution 0.94 mm isotropic T1- (TR = 2500 ms, TE = 2.2 ms, FA = 7°, FOV = 241 mm) and T2*-weighted (TR = 3200 ms, TE = 570 ms, FOV = 241 mm) sagittal sequence images were acquired of the whole brain. Next, functional MRI recordings were collected while participants performed the decision making task. For each functional run, a multiband T2*-weighted echo planar gradient-echo imaging sequence sensitive to BOLD contrast was acquired (TR = 910 ms, TE = 32 ms, FA = 52°, FOV = 192 mm, multiband factor 4) provided by the Center for Magnetic Resonance Research in accordance with a current license. Each functional image consisted of 64 coronal slices acquired perpendicular to the AC-PC plane (3 mm thick; 3x3 mm in-plane resolution). Coronal orientation is necessary when acquiring simultaneous impedance cardiography to avoid artifact [35 ].
5
fMRI Protocol for Whole-Brain Imaging
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fMRI was conducted on a Siemens 3T Magnetom Prisma Fit whole body MRI scanner (Siemens Healthcare GmbH, Erlangen, Germany) with a 32-channel head coil. Blood oxygen level-dependent (BOLD) data were collected using a T2*-weighted transversal echo planar imaging (EPI) sequence with interleaved slice acquisition, covering the entire brain (repetition time (TR) = 2000 ms, echo time (TE) = 30 ms, flip angle = 78°, number of slices = 34, slice thickness = 3 mm, slice gap = 0.3 mm, voxel size = 3 × 3 × 3 mm3, field of view (FOV) = 192 × 192 mm2, in-plane resolution = 64 × 64). To obtain a 3D structural scan, high-resolution sagittal T1-weighted images were acquired using a magnetisation prepared-rapid gradient echo (MPRAGE) sequence (TR = 2000 ms, TE = 2.98 ms, flip angle = 9°, number of slices = 176, slice thickness = 1 mm, slice gap = 0.5 mm, voxel size = 1 × 1 × 1 mm3, FOV = 256 × 256 mm2, in-plane resolution = 256 × 256).
6
Diffusion MRI of the Human Brain
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Diffusion MRI data were acquired on a Siemens 3T MAGNETOM PRISMAFit at the Martinos Center for Biomedical Imaging in Charlestown, MA, USA. Diffusion images were acquired using a dual echo-spin EPI sequence (repetition time = 4000 ms, echo time = 55 ms, flip angle = 90°, acquisition matrix = 128 mm × 128 mm). Seventy axial slices were acquired with 2 mm3 isotropic voxels in 64 gradient directions with b = 1000 s/mm2. 10 b = 0 scans were additionally collected.
7
Multimodal Brain Imaging Protocol for Neurological Research
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All participants underwent an MRI protocol on a Siemens 3T MAGNETOM Prismafit equipped with a 32-channel head coil. MRI protocol included: T1-weighted magnetization-prepared rapid gradient-echo (MP-RAGE) (repetition time (TR)/echo time (TE): 2400/2.07 ms, inversion time: 1000 ms, flip angle: 8°, echo train length: 0.49 ms, field-of-view: 256 mm (180 mm (RL), 256 mm (AP), 256 mm (FH)), slices: 224 (sagittal), resolution: 0.8 × 0.8 × 0.8 mm3); and a T2-weighted fluid-attenuated inversion recovery (FLAIR) (TR/TE: 6000/428 ms, inversion time: 2000 ms, echo train length: 933 ms, field-of-view: 256 mm (176 mm (RL), 256 mm (AP), 256 mm (FH)), slices: 176 (sagittal), resolution: 1.0 × 1.0 × 1.0 mm3).
8
Optimized Labeling Efficiency in 3T and 7T MRI
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Measurements were performed on a 3 T MAGNETOM Prisma Fit and a 7 T whole-body research scanner (Siemens Healthcare, Erlangen, Germany) using a 64-channel head/neck coil (Siemens Healthcare, Erlangen, Germany) and 32-channel head coil (Nova Medical, Wilmington, MA, USA), respectively. In order to improve the labeling efficiency at 7 T, two rectangular 18×18 cm 2 dielectric pads with 5 mm thickness (Teeuwisse et al., 2012) were placed on either side of the head at the level of the temporal lobes. At both 3 T and 7 T, the eye centers were taken as a reference for the magnet isocenter position (∼ level of pons), instead of the typically chosen eyebrows (∼level of basal ganglia) to minimize B 0 offsets in the labeling region. Furthermore, the brain-feeding arteries were aligned with the B 0 field by adding cushions below the necks of the participants when necessary. These measures were previously shown to improve labeling efficiency at 7 T (Ivanov et al., in press) . Half of the participants were first scanned at the 3 T scanner and then immediately transferred to the 7 T scanner, and vice versa for the other half of the participants. The two scanners are located within the same building at a walking distance of a few meters.
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