Cobas c111 auto analyzer

Manufactured by Roche

Sourced in United States, Germany

The Cobas c111 is an automated clinical chemistry analyzer designed for in vitro diagnostic testing. It is capable of performing a variety of routine clinical chemistry tests on patient samples. The Cobas c111 is intended for use in clinical laboratory settings.

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Lab products found in correlation

Multisizer 4 analyzer, by Beckman Coulter (1 mentions) Microvue dpd eia kit, by Quidel (1 mentions) Creatinine auto analyzer, by Hitachi (1 mentions) Radioimmunoassay, by Merck Group (1 mentions) Universal microplate reader, by Agilent Technologies (1 mentions)

Close spelling variants of this product

Cobas c111 analyzer Cobass c111 analyzer Cobas c111 Cobas analyzer

7 protocols using cobas c111 auto analyzer

Comprehensive Blood Parameter Profiling

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Five milliliters of blood was drawn from a vein using disposable syringes and then divided into two parts.
Two milliliters were transferred into an anticoagulant EDTA tube, which was used for the measurement of HbA1c and complete blood picture. HbA1c determination based on the turbidimetric inhibition immunoassay (TINIA) by using Cobas c 111 auto analyzer and a kit supplied by Roche company (Germany) (12) (link). Hemoglobin, RBCs, WBCs, Platelets, HCT, MCV, MCH and MCHC were all estimated in whole blood using Mythic 18 hematology auto analyzer (Orphee, France). The remaining blood was transferred into a plain tube, allowed to clot, centrifuged and analysed. Serum ferritin was determined through an automated enzyme-linked uorescent immunoassay (ELFA) using a kit supplied by BioMérieux (France) performed on a VIDAS device. Serum EPO was estimated, according to manufacturer instructions, by sandwich enzyme immunoassay test using universal microplate reader from BIO-TEK and a kit supplied by ELK Biotechnology (China). Glucose, creatinine, urea and uric acid were determined in serum photometrically using Cobas c111 auto analyzer and kits supplied by Roche company (Germany) (12, (link)13) .

Ahmed G.M., Abed M.N, & Alassaf F.A. (2024). Impact of calcium channel blockers and angiotensin receptor blockers on hematological parameters in type 2 diabetic patients. Naunyn-Schmiedeberg's archives of pharmacology, 397(3).

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Comprehensive Biochemical Analysis

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Electrolytes were analyzed with SFRI 4000 ion selective electrode (ISE), while plasma urea, creatinine, uric acid, total protein, albumin, serum aspartate amino transferase, and alanine amino transferase were analyzed using Cobas C111 autoanalyzer by Roche. Spot urine creatinine and protein were determined using Biosystem BTS 350 semi-autoanalyzer by Biosystems SFA Pro.

Ekun O.A., Olawumi O.M., Makwe C.C, & Ogidi N.O. (2018). Biochemical Assessment of Renal and Liver Function among Preeclamptics in Lagos Metropolis. International Journal of Reproductive Medicine, 2018, 1594182.

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Quantitative BAL Cell Analysis

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The total cell numbers, alveolar macrophages and polymorphonuclear leukocytes (PMNs) recovered by BAL were determined using a Beckman Coulter Multisizer 4 Analyzer (Beckman Coulter Indianapolis, IN, USA). Cells were differentiated using a Cytospin 3 centrifuge (Shandon Life Sciences International, Cheshire, England). Cell suspensions (1 × 10⁵ cells) were spun for 5 min at 72 × g and pelleted onto a slide. The cytospin preparations were stained with modified Wright–Giemsa stain, and cell differentials were determined by light microscopy. Differential cell counts were calculated by multiplying the total cell counts (~200 per rat) by the cell differential percentage obtained from the cytospin preparations. Using the acellular fraction of BALF, lactate dehydrogenase (LDH) activity, an indicator of general cell damage and toxicity, was measured. LDH activity was determined by measuring the oxidation of lactate to pyruvate coupled with the formation of NADH at 340 nm. Measurements were performed with a COBAS C111 auto-analyzer (Roche Diagnostics USA, Indianapolis, IN, USA).

Badding M.A., Fix N.R., Orandle M.S., Barger M.W., Dunnick K.M., Cummings K.J, & Leonard S.S. (2015). Pulmonary toxicity of indium-tin oxide production facility particles in rats. Journal of applied toxicology : JAT, 36(4), 618-626.

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Urinary Deoxypyridinoline Quantification

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Total urinary deoxypyridinoline was measured by EIA (MicroVue DPD EIA kit, Quidel), and expressed per urinary creatinine concentration. Urinary creatinine was analyzed with a Cobas c111 autoanalyzer (Roche Diagnostics).

Streicher C., Heyny A., Andrukhova O., Haigl B., Slavic S., Schüler C., Kollmann K., Kantner I., Sexl V., Kleiter M., Hofbauer L.C., Kostenuik P.J, & Erben R.G. (2017). Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells. Scientific Reports, 7, 6460.

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Fasting Blood Lipid Profile in Rats

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Rats were fasted for 6 hours with free access to water before blood samples were collected from the saphenous vein at baseline and 8 weeks for Phases 1 and 2, with additional collections at 10 and 12 weeks for Phase 2. Serum HDL-C, LDL-C, TC, and TG concentrations were determined using a Cobas c111 auto analyzer (Roche Diagnostics, Indianapolis, IN, USA). Fasting blood collection was performed on separate days from the vascular measurements.

Clark J.L., Loader T.B., Anderson H.D., Zahradka P, & Taylor C.G. (2020). Regular Black Bean Consumption Is Necessary to Sustain Improvements in Small-Artery Vascular Compliance in the Spontaneously Hypertensive Rat. Nutrients, 12(3), 685.

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Standardized Creatinine and Cystatin C Measurement

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Serum creatinine levels were measured by means of an isotope dilution mass spectrometry (IDMS) traceable assays both at PGI (modified Jaffe’s method using Cobas C111 auto-analyzer, Roche Diagnostics Limited) and in a central lab in Japan (enzymatic creatinine assay [5 (link)] using Hitachi creatinine auto-analyzer, model 7170, Hitachi). Serum Cys levels were measured in a central lab by colloidal gold immunoassay (Alfresa Pharma, http://www.alfresa-pharma.co.jp) which has been standardized for measurement of cystatin C traceable to ERM-DA471/IFCC [10 (link)].

Kumar V., Yadav A.K., Yasuda Y., Horio M., Kumar V., Sahni N., Gupta K.L., Matsuo S., Kohli H.S, & Jha V. (2018). Existing creatinine-based equations overestimate glomerular filtration rate in Indians. BMC Nephrology, 19, 22.

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Fasting Blood Lipid and Glucose Profiling

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A 40 mL fasting blood sample was collected from the antecubital vein into evacuated tubes and centrifuged at 1100× g at 4 °C for 20 min. EDTA-plasma was separated, stored at −80 °C, and analyzed with a Cobas C111 auto analyzer (Roche, Basel, Switzerland). The biomarkers were total cholesterol, HDL, LDL, triglycerides, hsCRP, and glucose. Insulin was measured via Radioimmunoassay (Millipore, Darmstadt, Germany). The Homeostatic Model of Insulin Resistance (HOMA-IR) was calculated with the formula of fasting insulin (mU/mL) × fasting glucose (mg/dL)/405 [90 (link)].

Patterson J., Shi X., Bresette W., Eghlimi R., Atlas S., Farr K., Vega-López S, & Gu H. (2021). A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox. Metabolites, 11(8), 552.

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