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Flumist tetra

Manufactured by AstraZeneca
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FluMist Tetra is a quadrivalent live attenuated influenza vaccine. It is administered as a nasal spray and contains four influenza virus strains.

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Lab products found in correlation

Fluenz tetra, by AstraZeneca (3 mentions) Fluarix tetra, by GlaxoSmithKline (3 mentions)

3 protocols using flumist tetra

1

Intranasal LAIV vs Quadrivalent Influenza Vaccination

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Healthy adult volunteers were 1:1 randomized to receive either intranasal LAIV (2015/2016 Fluenz Tetra or FluMist Tetra, AstraZeneca) or intramuscular quadrivalent inactivated influenza vaccination (Fluarix Tetra, GlaxoSmithKline), as described previously14 . The control group also received a nasal saline spray, while the LAIV group also received an intramuscular saline injection. Three days post-vaccination, all subjects were inoculated with 80,000 colony-forming units (CFU) per nostril of S. pneumoniae 6B type as described previously6 (link),51 . Nasal microbiopsies (ASL Rhino-Pro, Arlington Scientific) and nasal lining fluid samples (Nasosorption, Hunt Developments) were collected and stored at −80 °C as previously described52 (link).
Jochems S.P., Marcon F., Carniel B.F., Holloway M., Mitsi E., Smith E., Gritzfeld J.F., Solórzano C., Reiné J., Pojar S., Nikolaou E., German E.L., Hyder-Wright A., Hill H., Hales C., de Steenhuijsen Piters W.A., Bogaert D., Adler H., Zaidi S., Connor V., Gordon S.B., Rylance J., Nakaya H.I, & Ferreira D.M. (2018). Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nature Immunology, 19(12), 1299-1308.
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2

Influenza Vaccination and Pneumococcal Colonization

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Healthy adult volunteers were 1:1 randomized to receive either intranasally LAIV (2015/2016 Fluenz Tetra or FluMist Tetra, AstraZeneca, UK) or intramuscular Quadrivalent Inactivated Influenza Vaccination (Fluarix Tetra, GlaxoSmithKline, UK) as described previously 14 (link). The control group also received a nasal saline spray, while the LAIV group also received a intramuscular saline injection. Three days post vaccination all subjects were inoculated with 80,000 CFU per nostril of 6B type Spn as described 6 (link),51 (link). Nasal microbiopsies (ASL Rhino-Pro©, Arlington Scientific) and nasal lining fluid (Nasosorption™, Hunt Developments) samples were collected and stored at -80C as previously described 52 (link).
Jochems S.P., Marcon F., Carniel B.F., Holloway M., Mitsi E., Smith E., Gritzfeld J.F., Solórzano C., Reiné J., Pojar S., Nikolaou E., German E.L., Hyder-Wright A., Hill H., Hales C., de Steenhuijsen Piters W.A., Bogaert D., Adler H., Zaidi S., Connor V., Gordon S.B., Rylance J., Nakaya H.I, & Ferreira D.M. (2018). Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nature Immunology, 19(12), 1299-1308.
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3

Randomized Nasal Flu Vaccine Study

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The study was conducted as previously described [18] (link). Briefly, participants were randomised to receive either nasal LAIV (Fluenz Tetra or FluMist Tetra, AstraZeneca, UK; used interchangeably due to procurement shortages; both are pharmaceutically identical but have different packaging and labelling) with an intramuscular placebo (0.5 mL normal saline), or a nasal placebo (0.2 mL normal saline) with an intramuscular Tetravalent Inactivated Influenza Vaccination (TIV) (Fluarix Tetra, GlaxoSmithKline, UK). Participants were blindfolded during administration, with blinding maintained until completion of primary analysis. Experimental pneumococcal challenge comprised 80,000 colony forming-units (CFU) of penicillin-susceptible, mid-log phase grown Streptococcus pneumoniae serotype 6B (strain BHN418) in 0.1 mL saline instilled by laboratory pipette into each nostril [22] .
Hales C., Jochems S.P., Robinson R., Solórzano C., Carniel B., Pojar S., Reiné J., German E.L., Nikolaou E., Mitsi E., Hyder-Wright A.D., Hill H., Adler H., Connor V., Zaidi S., Lowe C., Fan X., Wang D., Gordon S.B., Rylance J, & Ferreira D.M. (2020). Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx. Vaccine, 38(10), 2298-2306.
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