Micro pet scanner

Manufactured by Siemens

Sourced in Germany

The Micro-PET scanner is a specialized medical imaging device designed for small animal research. It uses positron emission tomography (PET) technology to produce high-resolution images of the internal structures and functions of small animals, such as rodents. The core function of the Micro-PET scanner is to detect and measure the distribution of radioactive tracer compounds within the subject, providing researchers with valuable data for preclinical studies.

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Lab products found in correlation

Vivoquant ver 4, by Invicro (2 mentions) Inveon, by Siemens (2 mentions) Microct, by MILabs (2 mentions) Inevon research workplace 4, by Siemens (2 mentions) Inveon research workplace irw, by Siemens (1 mentions) Ge discovery mi, by GE Healthcare (1 mentions) Asi pro vm software, by Siemens (1 mentions) Three dimensional ordered subset expectation maximum algorithm, by Siemens (1 mentions)

Spelling variants of this product

Siemens scanners (11 citations) Micro-PET/CT scanner (7 citations) Inveon micro PET/CT animal scanner (6 citations) Inveon micro-PET/CT rodent model scanner (5 citations) Inveon Micro-CT/PET scanner (4 citations) Inveon combined micro-PET/CT scanner (3 citations) Focus 120 micro-PET scanner (2 citations) Inveon micro PET/CT Preclinical Scanner (2 citations) Inveon™ Hybrid Micro‐PET/CT Scanner (2 citations) Biograph micro-CT PET/CT scanner (2 citations)

17 protocols using micro pet scanner

PET Imaging of HIFU-Treated Brain Tumors

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[¹⁸F] FSPG: 10–20 min after HIFU treatment, B6 mice were injected i.v. with 4.7–5.7 MBq (128–153 μCi) of [¹⁸F] FSPG. 30 min post [¹⁸F] FSPG injection, mice were placed into a 4-mouse bed, and 30 min static PET images were acquired using a micro PET scanner (Siemens, Munich, Germany) followed by microCT (MIlabs, Houten, The Netherlands) on the same bed for anatomical reference.
[¹¹C] topotecan: 10–20 min post-HIFU treatment, B6 mice were placed into a 4-mouse bed and injected i.v. with 5.4–7.9 MBq (146–214 μCi) of [¹¹C] topotecan. 60 min dynamic PET images were acquired using a micro PET scanner (Siemens, Munich, Germany) followed by microCT (MIlabs, Houten, The Netherlands) on the same bed for anatomical reference.
For both [¹⁸F] FSPG and [¹¹C] topotecan studies, immediately after PET/CT scans, mice were euthanized, and their dissected brains were placed into 4% PFA and imaged for 10 min with static PET. Regions of interest (ROI) were manually drawn over the heart and the right brain hemisphere around the area targeted by HIFU using microCT as a reference. All PET images were reconstructed using the 3D-OSEM algorithm with 3-iterations in 256 × 256 matrix (Inveon, Siemens, Munich, Germany) and analyzed using VivoQuant ver 4 (Invicro, Boston, MA, USA).

Molotkov A., Carberry P., Dolan M.A., Joseph S., Idumonyi S., Oya S., Castrillon J., Konofagou E.E., Doubrovin M., Lesser G.J., Zanderigo F, & Mintz A. (2021). Real-Time Positron Emission Tomography Evaluation of Topotecan Brain Kinetics after Ultrasound-Mediated Blood–Brain Barrier Permeability. Pharmaceutics, 13(3), 405.

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In Vivo PET Imaging of Tumor-Bearing Mice

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Tumor-bearing mice (3–4 mice/group, n = 4) were anesthetized with isoflurane: O₂ (2% (V/V), 2 mL/min) and scanned using a micro-PET scanner (Siemens, Nürnberg, Germany) after intravenous injection of ⁶⁸Ga-NODA-CDV-Nb109 (4.0–5.0 MBq). Whole-body PET imaging was performed by dynamic scanning for 1 h and static imaging for 10 min. The tissue uptake of tracer was estimated using the technique of region of interest (ROI) and the results were expressed as percentage of radiotracer in the ROI relative to the injected total radioactive dose (%ID/mL).

Chen Y., Zhu S., Fu J., Lin J., Sun Y., Lv G., Xie M., Xu T, & Qiu L. (2022). Development of a radiolabeled site-specific single-domain antibody positron emission tomography probe for monitoring PD-L1 expression in cancer. Journal of Pharmaceutical Analysis, 12(6), 869-878.

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Small-animal PET Imaging of HER2 Expression

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Small-animal PET was performed with a microPET scanner (Siemens Inc.). Under isoflurane anesthesia, the mice were placed prone in the center of the field of view of the scanner and injected into 3.7MBq ¹⁸FAl-NOTA-MAL-MZHER_2:342 with or without excessive non-labeled Cys-MZHER_2:342 via the lateral tail vein. Whole-body scanning was performed at different times after radiotracer injection and a 10-min static PET images were acquired. The quantification analysis of PET images was performed using the same method as previously reported. 30 (link),31 (link)

Xu Y., Bai Z., Huang Q., Pan Y., Pan D., Wang L., Yan J., Wang X., Yang R, & Yang M. (2017). PET of HER2 Expression with a Novel 18FAl Labeled Affibody. Journal of Cancer, 8(7), 1170-1178.

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Imaging Tumor and Inflammation in Mice

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All of the tumor- and inflammation-bearing mice were imaged in the prone position in the MicroPET scanner (Siemens, Munich, Germany). The mice were anesthetized with 2% isoflurane and injected with 5.55-7.4 MBq of the new radiotracer via the tail vein. Static scans were obtained for 5 minutes at 1 and 2 hours post-injection (pi). The images were reconstructed by a two-dimensional ordered-subsets expectation maximum (OSEM2D) algorithm. After each micro-PET scan, the regions of interest (ROIs) were drawn over the tumor, liver, kidneys, and inflamed muscle on decay-corrected whole-body coronal images using Inveon Research Workplace (IRW, Siemens, Munich, Germany) to obtain the imaging ROI-derived percentage injected dose per gram of tissue (%ID/g).

Wang X., Zhang J., Han Z., Ma L, & Li Y. (2022). 18F-labeled Dimer-Sansalvamide A Cyclodecapeptide: A Novel Diagnostic Probe to Discriminate Pancreatic Cancer from Inflammation in a Nude Mice Model. Journal of Cancer, 13(6), 1848-1858.

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Tracheal Delivery of Radiolabeled OMVs in Chickens

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⁸⁹Zr-DFO-OMVs were administered into the trachea of three 7-day-old specific-pathogen-free chickens (SPF, Beijing, China). Static imaging was performed for 10 min at 0.25, 1, 2, 3, 12, and 36 h after injection, using a micro-PET scanner (Siemens, Germany) with a 3% volumetric fraction of mixed gas containing isoflurane and oxygen to induce and maintain anesthesia. The imaging time and the residual radioactivity in the syringe were recorded.
Another three 7-day-old SPF chickens were injected with ⁸⁹Zr-oxalate via the trachea as the blank control group for micro-PET imaging. The tracheal, lung, gastrointestinal tract, and kidney regions were delineated by ASIProVM software as regions of interest and the radioactive uptake values %ID/g of each region of interest at separate times were calculated.

Li Z., Niu L., Wang L., Mei T., Shang W., Cheng X., Li Y., Xi F., Song X., Shao Y., Xu Y, & Tu J. (2022). Biodistribution of 89Zr-DFO-labeled avian pathogenic Escherichia coli outer membrane vesicles by PET imaging in chickens. Poultry Science, 102(2), 102364.

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Micro-PET Imaging of Liver Fibrosis

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The micro-PET images of the BDL and CCl₄ models of liver fibrosis and control mice (sham group in 21 d, n=9; control group in 12 wk, n=10) were obtained using a micro-PET scanner (Siemens) as reported.¹² Briefly, static PET/CT images were acquired 1 hour after i.v. tail vein injection of [¹⁸F]AlF-ND-bisFAPI (4.44–5.55 MBq, 0.1 mL), with an acquisition of 10 minutes. Mice were anesthetized and scanned in the prone position. Blocking experiments were performed in the BDL model mice by coinjection of the FAP competitor DOTA-FAPI-04 (50 μg/mouse, n=5) at day 21 after operation. Images were reconstructed using a 3-dimensional ordered-subset expectation maximum algorithm (Siemens). Attenuation correction was performed using the unenhanced low-dose CT data. To quantify the tracer uptake in liver sections, the regions of interest were drawn manually on decay-corrected whole-body coronal images using the Inevon Research Workplace 4.1 software (Siemens). The mean standardized uptake value for each region of interest was recorded to avoid the influence of weight change.

Li H., Dai R., Huang Y., Zhong J., Yan Q., Yang J., Hu K, & Zhong Y. (2024). [18F]AlF-ND-bisFAPI PET imaging of fibroblast activation protein as a biomarker to monitor the progression of liver fibrosis. Hepatology Communications, 8(4), e0407.

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In Vivo Molecular Imaging of [18F]FNGA

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Mice were anaesthetized by chloral hydrate. Immediately after [¹⁸F]FNGA injection at 7.4 MBq/kg, a mouse was laid on a microPET scanner (Siemens, Germany) and serial static emission scanning was performed at 120 kV, 100 mA/s and with a 5 mm section cranial thickness. A whole-body PET emission scan was performed with 2-min acquisition per bed position using a 3-dimensional acquisition mode with 1 min interval in a total of 30 min. A second phase scanning was also performed immediately after the 30-min scan at 5 min per scan with 1 min interval for a total of 30 min. Region of interest (ROI) was drawn and the standardized uptake values (SUV) in each ROI was measured.

Du S.D., Li S.H., Jin B., Zhu Z.H., Dang Y.H., Xing H.Q., Li F., Wang X.B., Lu X., Sang X.T., Yang H.Y., Zhong S.X, & Mao Y.L. (2017). Potential application of neogalactosylalbumin in positron emission tomography evaluation of liver function. World Journal of Gastroenterology, 23(23), 4278-4284.

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Small-Animal PET Imaging of Neuroinflammation

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Small-animal PET was performed with a micro-PET scanner (Siemens Inc.). Under isoflurane anesthesia, the rats were placed prone in the center of the field of view of the scanner and injected with [18F] DPA-714 via the lateral tail vein. Whole-brain scanning was performed after radiotracer injection, and 10-min static PET images were acquired. The quantification analysis of PET images was performed using the same method as previously reported [25 (link)].

Wang Y.L., Han Q.Q., Gong W.Q., Pan D.H., Wang L.Z., Hu W., Yang M., Li B., Yu J, & Liu Q. (2018). Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats. Journal of Neuroinflammation, 15, 21.

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Pulmonary Inflammation Imaging with 68Ga-Albumin

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72 h after intranasal LPS treatment, B6 mice were injected iv with 436–473 μCi (16.1–17.5 MBq) of ⁶⁸Ga-albumin. 4 to 5 h after ⁶⁸Ga-albumin injection, mice were placed into a 4-mouse bed and 30 min static PET images were acquired using micro PET scanner (Siemens, Germany) followed by microCT (MIlabs, Netherlands) on the same bed for anatomical reference. Immediately after PET/CT acquisition, lungs were dissected, placed in 4% PFA in a 6-well culture plate, and a 30 min PET static image of the isolated lungs was acquired. All PET images were reconstructed using 3D-OSEM algorithm with 3-iterations in 256 × 256 matrix (Inveon, Siemens, Germany) and analyzed using VivoQuant ver 4 (Invicro, MA).

Molotkov A., Bhatt N., Doubrovin M., Castrillon J., Massa C., Gerber A., D’Armiento J., Goldklang M, & Mintz A. (2020). Multimodality molecular imaging of the alveolar-capillary barrier in lung disease using albumin based optical and PET tracers. Molecular Biomedicine, 1, 17.

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PET Imaging of Tumor Uptake in Mice

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⁶⁸Ga-citrate was produced by a ⁶⁸Ge/⁶⁸Ga generator. The PET-CT images of tumor-bearing mice were obtained by a GE Discovery MI PET/CT scanner (GE Healthcare, Milwaukee, MI, USA) with AW workstation and a Micro-PET scanner (Siemens, Erlangen, Germany) equipped with Inveon Research Workplace 4.1 software. Before the scan, all mice were anesthetized and injected with 3.7 MBq (100 Ci) ⁶⁸Ga-citrate. PET imaging acquisition was conducted 60 min after injection. After the image acquisition, attenuation correction was performed using the workstation-specific software of PET-CT, and then, the images were reconstructed to obtain images of three cross-sections: transverse, sagittal and coronal. The regions of interest (ROIs) of tumors and thigh muscle tissue areas were delineated in the reconstructed images. Finally, data results were calculated as the tumor uptake target to normal tissue ratio (TNR).

Qiu J., Wu R., Long Y., Peng L., Yang T., Zhang B., Shi X., Liu J, & Zhang X. (2022). Role of Fe, Transferrin and Transferrin Receptor in Anti-Tumor Effect of Vitamin C. Cancers, 14(18), 4507.

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